INT60956

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Context Info
Confidence 0.47
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 2.49
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
transmembrane transport (Abcb1b)
Anatomy Link Frequency
brain 2
P388 1
Abcb1b (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 11 100.00 Very High Very High Very High
Opioid 12 99.60 Very High Very High Very High
Analgesic 8 98.44 Very High Very High Very High
imagery 4 98.28 Very High Very High Very High
Antinociceptive 1 92.64 High High
Morphine 8 92.16 High High
Crohn's disease 6 91.20 High High
Kinase C 2 85.08 High High
lidocaine 2 82.24 Quite High
tolerance 4 77.20 Quite High
Disease Link Frequency Relevance Heat
Cancer 29 100.00 Very High Very High Very High
Breast Cancer 10 100.00 Very High Very High Very High
Leukemia 2 100.00 Very High Very High Very High
Inflammatory Bowel Disease 32 99.82 Very High Very High Very High
Disease 14 91.20 High High
Sprains And Strains 104 90.16 High High
Hypophosphatemia 3 75.40 Quite High
Recurrence 4 66.56 Quite High
Stress 7 65.28 Quite High
Sepsis 9 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction of nonpeptidic delta agonists with P-glycoprotein by in situ mouse brain perfusion: liquid chromatography-mass spectrometry analysis and internal standard strategy.
P-glycoprotein Binding (Interaction) of in brain associated with agonist
1) Confidence 0.47 Published 2002 Journal J Pharm Sci Section Title Doc Link 11782913 Disease Relevance 0 Pain Relevance 0.19
Some opioids have been shown to interact with P-gp in vitro and in vivo.
P-gp Binding (interact) of associated with opioid
2) Confidence 0.47 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14698039 Disease Relevance 0 Pain Relevance 0.58
It is known that opioid analgesics given systemically have limited distribution into the brain because of their interaction with P-glycoprotein (P-gp), an ATP-dependent efflux pump acting at the blood-brain barrier (BBB).
P-gp Binding (interaction) of in brain associated with analgesic and opioid
3) Confidence 0.47 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18071274 Disease Relevance 0 Pain Relevance 0.86
Fluorescence intensities for MDR1 (?
MDR1 Binding (intensities) of
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0.05
atpase6, ubp-1 and mdr1 genotypes in AS-ATNMF1
mdr1 Binding (genotypes) of
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0.07 Pain Relevance 0.04
This was the only genetic alteration detected following inspection of ubp1, atpase6 and mdr1 itself, the major candidate genes previously reported to be associated to resistance to the drugs used here.
mdr1 Binding (inspection) of
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0.06 Pain Relevance 0
Is it possible that the ubp-1 mutation is acting in concert with the mdr1 duplication in determining the ATN + MF resistance phenotype by, for instance, reducing ubiquitination of MDR1 and either allowing its increased turnover or modifying its localisation within the parasite?
MDR1 Binding (ubiquitination) of
7) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
Using differential scanning calorimetry and NMR techniques and artificial membranes composed of phosphatidylcholine or phosphatidylserines we found a significant correlation between the MDR-reversing activity of the drugs in doxorubicin-resistant human breast carcinoma MCF-7/DOX and murine leukaemia P388/DOX tumour cells (data taken from the literature) and their ability to interact with phosphatidylserines.
MDR Binding (interact) of in P388 associated with leukemia, cancer and breast cancer
8) Confidence 0.22 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8543589 Disease Relevance 0.30 Pain Relevance 0.12
The multidrug-resistance (MDR)-reversing ability of the catamphiphilic drugs could be mediated through their interaction with the membrane phospholipids.
MDR Binding (interaction) of
9) Confidence 0.22 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8543589 Disease Relevance 0 Pain Relevance 0.04
Their data also support the association of the SXR locus with extensive UC and the interaction between SXR and MDR1 genes.
MDR1 Binding (interaction) of associated with inflammatory bowel disease
10) Confidence 0.07 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.68 Pain Relevance 0.21
Phosphate Supplementation Protects Mice from Lethality Following Intestinal Exposure to either MDR25R or MDR1
MDR1 Binding (either) of
11) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2242829 Disease Relevance 0.38 Pain Relevance 0

General Comments

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