INT6097

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Context Info
Confidence 0.57
First Reported 1983
Last Reported 2007
Negated 1
Speculated 2
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 9.71
Pain Relevance 6.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NEUROD1) nucleus (NEUROD1) transcription factor binding (NEUROD1)
cytoplasm (NEUROD1)
Anatomy Link Frequency
plasma 1
myometrium 1
uterine 1
PGE2 1
spinal 1
NEUROD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 16 100.00 Very High Very High Very High
tetrodotoxin 4 100.00 Very High Very High Very High
Mexiletine 8 99.86 Very High Very High Very High
agonist 7 98.64 Very High Very High Very High
Angina 8 97.62 Very High Very High Very High
analgesia 6 97.28 Very High Very High Very High
epidural 10 96.88 Very High Very High Very High
beta blocker 17 96.52 Very High Very High Very High
Pain 12 96.28 Very High Very High Very High
sodium channel 4 94.72 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 2 99.88 Very High Very High Very High
Injury 4 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 9 99.18 Very High Very High Very High
Arrhythmia Under Development 2 98.44 Very High Very High Very High
Cv General 3 Under Development 8 97.62 Very High Very High Very High
Hypertension 13 97.28 Very High Very High Very High
Pain 6 96.28 Very High Very High Very High
Adverse Drug Reaction 3 95.96 Very High Very High Very High
Stress 6 95.32 Very High Very High Very High
Pressure And Volume Under Development 5 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resistance to antihypertensive drugs in patients of both groups was overcome by PGE2 infusions, and was correlated with a decrease in lymphocyte beta 2-adrenoceptor density, an increase in beta 2-receptor affinity for l-isoproterenol, and an increase in adenylate cyclase activation.
Negative_regulation (decrease) of beta 2 in PGE2
1) Confidence 0.57 Published 1992 Journal Am. J. Hypertens. Section Abstract Doc Link 1321638 Disease Relevance 0.30 Pain Relevance 0.09
Sustained decreases in beta 2-microglobulin, neopterin, and p24 antigen levels were seen over the 52-week study.
Negative_regulation (decreases) of beta 2
2) Confidence 0.57 Published 1995 Journal J. Infect. Dis. Section Abstract Doc Link 7751691 Disease Relevance 0.60 Pain Relevance 0.18
The following properties of beta-blockers and the therapeutic relevance of these properties are to be discussed, together with pertinent examples of the drugs involved: beta 1-receptor selectivity and the degree of beta 2-receptor blockade; intrinsic sympathomimetic activity (ISA); duration of action (to be discussed in connection with the pharmacokinetic properties in Prof.
Negative_regulation (blockade) of beta 2 associated with beta blocker
3) Confidence 0.57 Published 1990 Journal Clin Physiol Biochem Section Abstract Doc Link 1982758 Disease Relevance 0.39 Pain Relevance 0.16
At the same time, in most cases fast wave activity (alpha 1, alpha 2, beta 1 and beta 2) was decreased by more than 50% at identical cortical areas.
Negative_regulation (decreased) of beta 2
4) Confidence 0.57 Published 1993 Journal Anaesthesist Section Abstract Doc Link 8480900 Disease Relevance 0.06 Pain Relevance 0.15
Labetalol is a competitive antagonist of alpha 1-, beta 1-, and beta 2-adrenergic receptors.
Negative_regulation (antagonist) of beta 2 associated with antagonist
5) Confidence 0.42 Published 1983 Journal Drug Intell Clin Pharm Section Abstract Doc Link 6354658 Disease Relevance 0.35 Pain Relevance 0.09
Following 4- or 21-day periods of monocular deprivation induced by intravitreal injections of tetrodotoxin, levels of the alpha 1, alpha 2, alpha 4, alpha 5, beta 1, and beta 2 mRNAs were decreased in the deprived geniculate laminae.
Negative_regulation (decreased) of beta 2 associated with tetrodotoxin
6) Confidence 0.42 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7721992 Disease Relevance 0.16 Pain Relevance 0.10
Push/pull HDF showed significantly greater removal of beta 2-microglobulin (beta 2-m) and other small molecular proteins than HD, and serum beta 2-m was significantly lower in concentration with push/pull HDF than HD.
Negative_regulation (removal) of beta 2
7) Confidence 0.42 Published 1990 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 2190031 Disease Relevance 0.42 Pain Relevance 0.33
Consistent with its ability to inhibit PLC-beta2 enzymatic activity, U73122 reduced interleukin-8 and leukotriene B(4)-induced Ca(2+) flux and chemotaxis in human neutrophils in a concentration-dependent manner.
Negative_regulation (inhibit) of beta2 in neutrophils
8) Confidence 0.42 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14730005 Disease Relevance 0.30 Pain Relevance 0.10
Following 4- or 21-day periods of monocular deprivation induced by intravitreal injections of tetrodotoxin, levels of the alpha 1, alpha 2, alpha 4, alpha 5, beta 1, and beta 2 mRNAs were decreased in the deprived geniculate laminae.
Negative_regulation (deprivation) of beta 2 associated with tetrodotoxin
9) Confidence 0.42 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7721992 Disease Relevance 0.16 Pain Relevance 0.10
These results suggest that pindolol blocked both beta 1 and beta 2 receptors, and therefore, this resulted in exaggerated alpha effects of epinephrine, a remarkable systemic vasoconstriction, and pulmonary congestion.
Negative_regulation (blocked) of beta 2 associated with increased venous pressure under development
10) Confidence 0.41 Published 1993 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 8488340 Disease Relevance 0.41 Pain Relevance 0.30
In the patients who received only the 60 min dose, the plasma adrenaline concentrations increased more, but the plasma level of cyclic AMP (a marker for beta 2-stimulation) increased similarly, which suggests that beta 2-adrenoceptor responsiveness was somewhat reduced.
Negative_regulation (reduced) of beta 2 in plasma
11) Confidence 0.41 Published 1995 Journal Eur J Anaesthesiol Section Abstract Doc Link 8542857 Disease Relevance 0.32 Pain Relevance 0.43
This lack of a hypokalaemic effect might be partly due to reduced responsiveness of beta 2-adrenoceptors to adrenaline.
Negative_regulation (responsiveness) of beta 2
12) Confidence 0.41 Published 1995 Journal Eur J Anaesthesiol Section Abstract Doc Link 8542857 Disease Relevance 0.30 Pain Relevance 0.41
Monocular deprivation for 1-3 weeks, induced by intravitreal injection of tetrodotoxin, resulted in substantial reductions in levels of alpha 1, beta 2, and gamma 2 subunit mRNAs in deprived ocular dominance columns of the visual cortex, but the other subunit mRNAs were largely unaffected by monocular deprivation.
Negative_regulation (reductions) of beta 2 in cortex associated with tetrodotoxin
13) Confidence 0.41 Published 1997 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9250379 Disease Relevance 0 Pain Relevance 0.20
Coexpression of beta-adrenergic receptor kinase 2 (beta-ARK2) and beta-arrestin 2 (beta-arr2) synergistically produced a rapid desensitization of both DOR and beta2-adrenergic receptor signaling with a t1/2 < 4 min. beta-ARK2 and beta-arr2 more slowly desensitized MOR responses; a similar synergistic effect on MOR required 2-3 h of agonist treatment.
Negative_regulation (desensitization) of beta2 associated with agonist
14) Confidence 0.41 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9346897 Disease Relevance 0 Pain Relevance 0.24
We first examined the effects of U73122 on human phospholipase C-beta (PLC-beta) isozymes and found that U73122 significantly inhibited recombinant human PLC-beta2, with an IC(50) of approximately 6 microM.
Negative_regulation (inhibited) of beta2
15) Confidence 0.41 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14730005 Disease Relevance 0.29 Pain Relevance 0.08
We thought that the use of landiolol was more rational and was preferable to a nonselective beta receptor blocker for a term-pregnant woman because blockade of the beta2 receptor might cause uterine contraction.
Negative_regulation (blockade) of beta2 in uterine
16) Confidence 0.41 Published 2005 Journal J Anesth Section Abstract Doc Link 15875139 Disease Relevance 0.48 Pain Relevance 0.12
The synovial tissue was labeled with anti-ubiquitin antibody, indicating co-deposition of ubiquitin with beta 2-M amyloid.
Negative_regulation (co-deposition) of beta 2 associated with alzheimer's dementia
17) Confidence 0.41 Published 1993 Journal Clin. Chim. Acta Section Abstract Doc Link 8111958 Disease Relevance 0.42 Pain Relevance 0
Individuals with greater immune compromise (CD4, < 200, beta 2-M, > or = 5) were more impaired on measures of motor functioning. beta 2-M was found to be a better predictor than CD4 count of impaired neuropsychological performance.
Negative_regulation (predictor) of beta 2
18) Confidence 0.41 Published 1994 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 7916050 Disease Relevance 0.92 Pain Relevance 0.05
Thus it is likely that multiple mechanisms are involved in CS-induced immune alterations and these results clearly implicate beta 1 and beta 2-adrenergic receptors in a subset of immunomodulatory effects.
Spec (implicate) Negative_regulation (implicate) of beta 2
19) Confidence 0.41 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1351060 Disease Relevance 0.06 Pain Relevance 0.18
In the treatment of hypertension, angina pectoris, and certain types of cardiac arrhythmia the therapeutic benefit is mediated by beta 1-receptor blockade, whereas the blockade of beta 2-adrenoceptors does usually not contribute to the therapeutic efficacy and is rather associated with adverse reactions.
Negative_regulation (blockade) of beta 2 associated with adverse drug reaction, angina, hypertension and arrhythmia under development
20) Confidence 0.41 Published 1990 Journal Clin Physiol Biochem Section Abstract Doc Link 1982758 Disease Relevance 0.39 Pain Relevance 0.17

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