INT60970

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 16
Disease Relevance 12.21
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
kidney 1
Scr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 32 99.44 Very High Very High Very High
Analgesic 10 97.84 Very High Very High Very High
Angina 4 87.72 High High
addiction 16 87.56 High High
anesthesia 4 81.80 Quite High
cytokine 6 65.96 Quite High
antagonist 7 58.92 Quite High
ischemia 13 55.40 Quite High
chemokine 2 50.80 Quite High
Pain 1 43.60 Quite Low
Disease Link Frequency Relevance Heat
Proteinuria 18 100.00 Very High Very High Very High
Chronic Renal Failure 402 99.90 Very High Very High Very High
Disease 84 99.90 Very High Very High Very High
INFLAMMATION 37 99.44 Very High Very High Very High
Renal Disease 22 98.70 Very High Very High Very High
Hypertension 168 97.80 Very High Very High Very High
Disorder Of Lipid Metabolism 6 96.18 Very High Very High Very High
Myocardial Infarction 19 95.44 Very High Very High Very High
Nephrotoxicity 5 95.40 Very High Very High Very High
Diabetes Mellitus 130 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nineteen patients were divided into two groups on the basis of increases in Scr (delta Scr): a worsened group (group A) (delta Scr > or = 1mg/dl after coronary intervention; 6 patients) and an unchanged group (group B) (delta Scr < 1 mg/dl ; 13 patients).
Positive_regulation (increases) of Scr
1) Confidence 0.59 Published 1997 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 9134832 Disease Relevance 0.54 Pain Relevance 0.09
Nineteen patients were divided into two groups on the basis of increases in Scr (delta Scr): a worsened group (group A) (delta Scr > or = 1mg/dl after coronary intervention; 6 patients) and an unchanged group (group B) (delta Scr < 1 mg/dl ; 13 patients).
Positive_regulation (increases) of Scr
2) Confidence 0.59 Published 1997 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 9134832 Disease Relevance 0.54 Pain Relevance 0.09
The post-procedure mean peak of Scr [(101.62 +/- 42.98) micromol/L vs. (117.67 +/- 68.77) micromol/L, P = 0.047] and the post-procedure increasing Scr from baseline (DeltaScr) [(13.49 +/- 19.61) micromol/L vs. (22.50 +/- 18.31) micromol/L, P = 0.001] in the probucol group decreased significantly compared with that of control group.
Positive_regulation (increasing) of Scr
3) Confidence 0.35 Published 2009 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Body Doc Link 19781209 Disease Relevance 0 Pain Relevance 0
Herein, we also showed that simultaneous deletion of both receptors resulted in extremely high levels of sCr and in a pro-inflammatory profile.
Positive_regulation (levels) of sCr associated with inflammation
4) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.94 Pain Relevance 0.35
We also show that this variant interacts with age-related increase in SCr levels with little or no effect on SCr before the age of 50 years, followed by a rapidly growing effect with increasing age.
Positive_regulation (increase) of SCr
5) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.67 Pain Relevance 0
Furthermore, we also observed a significantly higher rate of SCr increase with age and rs4293393-T allele count stratifying on the number of comorbid conditions present (P?
Positive_regulation (increase) of SCr
6) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.98 Pain Relevance 0
In parallel with previous studies, the rate of increase in SCr with age was significantly higher in individuals with HTN than in individuals without this diagnosis (effect?
Positive_regulation (increase) of SCr associated with hypertension
7) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 1.23 Pain Relevance 0
At the LUH, the same enzymatic method was used for measurement of SCr during the study period (Vitros 950 Autoanalyzer, Ortho Clinical Diagnostics, Rochester, MN, USA), whereas at the Laboratory in Mjodd, SCr measurements were performed by modified kinetic Jaffe rection assays until May 2007 when an enzymatic method was introduced.
Positive_regulation (measurement) of SCr
8) Confidence 0.18 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.87 Pain Relevance 0
8) association to increased risk of CKD and elevated SCr.
Positive_regulation (elevated) of SCr associated with chronic renal failure
9) Confidence 0.18 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.53 Pain Relevance 0.04
These findings, demonstrating not only the effect of age on UMOD-associated increase in SCr but also the effect of age-related comorbid conditions, may explain why no association was observed between rs4293393-T and kidney function in the Dutch sample set of healthy population-based subjects with much lower SCr values and of much less variability than observed in the Icelandic samples (Figure S3).


Positive_regulation (increase) of SCr in kidney
10) Confidence 0.18 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.52 Pain Relevance 0
UMOD-associated increase in SCr with age is affected by the number of comorbid conditions present
Positive_regulation (increase) of SCr
11) Confidence 0.18 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 1.29 Pain Relevance 0
Thus, the variant does not affect SCr in young individuals but rather how SCr increases with age.
Positive_regulation (increases) of SCr
12) Confidence 0.17 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.26 Pain Relevance 0
There was an increase in BUN, Scr, and potassium levels and decrease in sodium levels in cyclosporine alone treated group, suggesting a significant nephrotoxicity.
Positive_regulation (increase) of Scr associated with nephrotoxicity
13) Confidence 0.07 Published 1996 Journal Transplantation Section Abstract Doc Link 8781605 Disease Relevance 0.29 Pain Relevance 0.08
RESULTS: There were significant reductions of MAP, T, and Ht and a significant increase of SCr.
Positive_regulation (increase) of SCr
14) Confidence 0.03 Published 2006 Journal Ren Fail Section Body Doc Link 16526323 Disease Relevance 0 Pain Relevance 0
Urinary data were obtained for comparison purpose in five groups of proteinuric patients: two groups with normal serum creatinine (SCr) and glomerular albuminura [12 patients with diabetes mellitus and microalbuminuria (DN), 10 patients with primary nephrotic syndrome (NS)]; two groups with normal SCr and toxic nephropathy [6 patients with analgesic (AN), 9 patients with cadmium nephropathy (CdN)]; and one group of seven patients with glomerular diseases and increased SCr (GN).
Positive_regulation (increased) of SCr associated with diabetes mellitus, analgesic, renal disease, disease and disorder of lipid metabolism
15) Confidence 0.03 Published 1995 Journal Kidney Int. Section Abstract Doc Link 8544416 Disease Relevance 1.54 Pain Relevance 0.20
CHN2, P < 0.05) as well as a further increase in total proteinuria and SCr.
Positive_regulation (increase) of SCr associated with proteinuria
16) Confidence 0.03 Published 1995 Journal Kidney Int. Section Abstract Doc Link 8544416 Disease Relevance 1.99 Pain Relevance 0.19

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