INT60974

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Context Info
Confidence 0.71
First Reported 1995
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 34
Total Number 37
Disease Relevance 7.48
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Scgb1a1) extracellular space (Scgb1a1) extracellular region (Scgb1a1)
endoplasmic reticulum (Scgb1a1) cytoplasm (Scgb1a1)
Anatomy Link Frequency
lung 4
brain 3
alveolar cell 2
Clara cells 2
epithelial cell 1
Scgb1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 95.12 Very High Very High Very High
anesthesia 35 91.20 High High
Inflammation 219 89.08 High High
Central nervous system 9 88.36 High High
Inflammatory response 8 82.20 Quite High
Pain 4 78.88 Quite High
chemokine 4 56.48 Quite High
Analgesic 5 42.24 Quite Low
fibrosis 116 38.36 Quite Low
Neurobehavioral 3 20.56 Low Low
Disease Link Frequency Relevance Heat
Cyst 2 100.00 Very High Very High Very High
Nicotine Addiction 52 99.44 Very High Very High Very High
Obesity 65 99.00 Very High Very High Very High
Metastasis 75 98.84 Very High Very High Very High
Targeted Disruption 104 98.72 Very High Very High Very High
Bronchitis 13 97.68 Very High Very High Very High
Brain Tumor 18 96.60 Very High Very High Very High
Melanoma 36 95.40 Very High Very High Very High
Weight Loss 1 93.28 High High
Apoptosis 55 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, the O3 concentration was approximately one-fourth of the O3 concentration that recently was found to increase the serum CC16 levels in adult subjects (n = 22) exposed for 2 hr in an exposure chamber to 400 ?
Gene_expression (levels) of CC16
1) Confidence 0.71 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.05 Pain Relevance 0
Thus, a possible increase in the intravascular leakage of CC16 caused by, for example, O3 exposure could be masked by a decrease in the production of CC16 in swimmers (Bernard et al. 2003; Carbonelle et al. 2002).
Gene_expression (production) of CC16
2) Confidence 0.62 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0 Pain Relevance 0
This may be caused by a decrease in the production of CC16 depending on a decreased number of Clara cells (Hermans and Bernard 1999).
Gene_expression (production) of CC16 in Clara cells
3) Confidence 0.62 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.37 Pain Relevance 0.06
The serum CC16 levels found in this study did not correlate with BMI, a result that has been shown in other studies as well (Hermans et al. 1998).
Gene_expression (levels) of CC16 associated with obesity
4) Confidence 0.62 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.16 Pain Relevance 0
That this could be the case also in our study is indicated by the tendency toward a correlation between short-term O3 exposure and the serum CC16 levels in non-pool visitors, but not in pool visitors, after exercise.
Gene_expression (levels) of CC16
5) Confidence 0.55 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0 Pain Relevance 0
Lower CC16 levels among subjects regularly attending chlorinated swimming pools are in accordance with the findings by our Belgian partners in the HELIOS project (Bernard et al. 2003; Carbonelle et al. 2002).
Gene_expression (levels) of CC16
6) Confidence 0.54 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0 Pain Relevance 0
The correlations between O3 exposure and CC16 levels before or after exercise outdoors were not statistically significant in the group as a whole.
Gene_expression (levels) of CC16
7) Confidence 0.54 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.20 Pain Relevance 0
The correlations between O3 exposure and CC16 levels before or after exercise outdoors were not statistically significant in the group as a whole.
Gene_expression (exposure) of CC16
8) Confidence 0.54 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.20 Pain Relevance 0
However, children who regularly visited chlorinated indoor swimming pools had significantly lower CC16 levels in serum than did nonswimming children both before and after exercise (respectively, 57 ± 2.4 and 53 ± 1.7 ?
Gene_expression (levels) of CC16
9) Confidence 0.54 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1253671 Disease Relevance 0.19 Pain Relevance 0.06
No significant differences were found between pre- and postexposure levels of serum CC16, nor did the time spent outdoors (mean, 6 hr) during the 2 days preceding the test day have any influence on the CC16 levels.
Gene_expression (levels) of CC16
10) Confidence 0.54 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.41 Pain Relevance 0
In contrast, we find that silica induced expression of the MMP inhibitor, TIMP1, in the lung of mice, and this enhanced expression was not altered in the lungs of the CCSP-dnI?
Gene_expression (lungs) of CCSP in lungs
11) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.30 Pain Relevance 0.16
The general aim of the present program, which was part of a European Union project (HELIOS), was to examine lung function and possible changes in the serum levels of CC16 in relation to ambient O3 exposure in Italy, France, Belgium, and Sweden (Bernard et al. 2003).
Gene_expression (levels) of CC16 in lung
12) Confidence 0.48 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.23 Pain Relevance 0.04
There were no significant differences between the levels of CC16 before and after outdoor exercise.
Gene_expression (levels) of CC16
13) Confidence 0.48 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.07 Pain Relevance 0
There were no significant correlations between the serum CC16 levels and parental smoking or BMI.
Gene_expression (levels) of CC16 associated with nicotine addiction and obesity
14) Confidence 0.48 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.46 Pain Relevance 0
Details of the generation of the CCSP-dnI?
Gene_expression (generation) of CCSP
15) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.40 Pain Relevance 0.08
Generation of CCSP and SPC-dnI?
Gene_expression (Generation) of CCSP
16) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.33 Pain Relevance 0.09
However, silica-induced lung MMP2 transcripts were less in CCSP-dnI?
Gene_expression (were) of CCSP in lung
17) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.79 Pain Relevance 0.17
Thus, the Sox17-induced bronchiolar-like structures contained a mixed population of cells that expressed CCSP, Foxj1, Sca-1, CCSP+/Sca-1+, and CCSP+/proSP-C+, consistent with reprogramming of progenitor cells along several differentiated pathways.
Gene_expression (expressed) of CCSP
18) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Since the ability of Sox17 to reprogram mature alveolar type II cells suggests the induction of progenitor cell behavior, we examined the bronchiolar-like structures for coexpression of CCSP, proSP-C, and Sca-1, a property attributed to bronchoalveolar stem cells (BASCs), a potential lung stem/progenitor population [32].
Gene_expression (coexpression) of CCSP in stem
19) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Foxa1, Foxa2, and GATA6 influence the expression of differentiated respiratory epithelial cell markers, including CCSP and Foxj1 [42]–[44].
Gene_expression (expression) of CCSP in epithelial cell
20) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0

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