INT60975

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.40
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CST3) extracellular region (CST3) endoplasmic reticulum (CST3)
lysosome (CST3) cytoplasm (CST3)
Anatomy Link Frequency
plasma 1
dorsal 1
astrocytes 1
Clara cell 1
CST3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.56 Very High Very High Very High
Lasting pain 2 99.46 Very High Very High Very High
Inflammation 2 99.00 Very High Very High Very High
bradykinin 5 94.16 High High
Dynorphin 4 91.88 High High
anesthesia 3 91.76 High High
Dorsal horn 2 90.40 High High
Pain 14 85.72 High High
Neuropeptide 2 75.00 Quite High
Enkephalin 1 69.96 Quite High
Disease Link Frequency Relevance Heat
Injury 12 99.96 Very High Very High Very High
Cyst 2 99.92 Very High Very High Very High
Pain 14 99.46 Very High Very High Very High
INFLAMMATION 2 99.00 Very High Very High Very High
Toxicity 1 97.60 Very High Very High Very High
Weight Loss 1 91.88 High High
Renal Disease 10 87.24 High High
Proteinuria 10 75.00 Quite High
Diabetes Mellitus 1 52.40 Quite High
Disorder Of Lipid Metabolism 3 46.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of these coded for cystatin C, a secreted cysteine protease inhibitor in the cystatin superfamily.
Localization (secreted) of cystatin C
1) Confidence 0.78 Published 2003 Journal Pain Section Abstract Doc Link 12670666 Disease Relevance 0.31 Pain Relevance 0.30
Urinary excretion of five low molecular weight proteins (LMWP) [beta 2-microglobulin (beta 2m), cystatin C (cyst C), Clara cell protein (CC16), retinol-binding protein (RBP) and alpha 1-microglobulin (alpha 1m)], albumin and N-acetyl-beta-D-glucosaminidase (NAG) were quantified in 16 patients who followed a weight reduction program which included Chinese herbs, which have been incriminated in the genesis of Chinese herbs nephropathy (CHN).
Localization (excretion) of cystatin C in Clara cell associated with weight loss, renal disease and cyst
2) Confidence 0.68 Published 1995 Journal Kidney Int. Section Abstract Doc Link 8544416 Disease Relevance 0.64 Pain Relevance 0
These data are consistent with our previous animal study and the idea that persistent pain induces the synthesis and release of cystatin C in dorsal spinal cord, the surplus of which overflows into the CSF.
Localization (release) of cystatin C in dorsal associated with pain, lasting pain and spinal cord
3) Confidence 0.68 Published 2003 Journal Pain Section Abstract Doc Link 12670666 Disease Relevance 0.56 Pain Relevance 0.64
Further on, it was shown that human brain cathepsin H activity could be controlled in vivo by cystatin C in its full-length form or its [delta1-10] variant, already known to be co-localized in astrocytes, since the Ki values for the inhibition are in the 10(-10) M range.
Localization (localized) of cystatin C in astrocytes
4) Confidence 0.68 Published 2003 Journal Peptides Section Abstract Doc Link 15127951 Disease Relevance 0 Pain Relevance 0.48
METHODS: The effect of rofecoxib on GFR measured using inulin clearance (C(in)), creatinine clearance (C(Cr)) serum cystatin C concentration (S(cystatin)), tubular creatinine secretion (using the ratio C(Cr)/C(in)), 24-hour urinary excretion of albumin (U(alb)V) and prostaglandins (U(PGE2)V and U(PGF2alpha)V), basal and stimulated plasma renin activity (PRA) and serum aldosterone concentration S(aldosterone) was evaluated before and on Day 7 during rofecoxib treatment.
Localization (secretion) of cystatin C in plasma
5) Confidence 0.68 Published 2005 Journal Int J Clin Pharmacol Ther Section Body Doc Link 16163893 Disease Relevance 0 Pain Relevance 0
For example, NGAL and cystatin C have been used in a safety monitoring trial of hydroxyethylstarch therapy and to detect AKI early, during or immediately after cardiac surgery.
Localization (detect) of cystatin C associated with injury
6) Confidence 0.32 Published 2010 Journal Minerva Anestesiol Section Abstract Doc Link 20473256 Disease Relevance 0.90 Pain Relevance 0.17

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