INT6098

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Context Info
Confidence 0.47
First Reported 1980
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 3.40
Pain Relevance 5.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NEUROD1) nucleus (NEUROD1) transcription factor binding (NEUROD1)
cytoplasm (NEUROD1)
Anatomy Link Frequency
leukocytes 2
plasma 1
saphenous vein 1
nerve 1
lymphocytes 1
NEUROD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 69 100.00 Very High Very High Very High
Nicotine 66 99.98 Very High Very High Very High
Neurotransmitter 5 99.98 Very High Very High Very High
Mexiletine 24 99.76 Very High Very High Very High
Clonidine 9 99.18 Very High Very High Very High
Catecholamine 23 97.98 Very High Very High Very High
Opioid 5 97.78 Very High Very High Very High
Inflammatory marker 1 97.58 Very High Very High Very High
lidocaine 9 96.56 Very High Very High Very High
gABA 12 96.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 5 99.28 Very High Very High Very High
Amyloid Plaque 1 98.66 Very High Very High Very High
INFLAMMATION 3 97.42 Very High Very High Very High
Weight Loss 7 94.60 High High
Amyloidosis 5 94.32 High High
Disease Susceptibility 1 91.16 High High
Alzheimer's Dementia 2 89.12 High High
Urological Neuroanatomy 2 88.92 High High
Low Back Pain 2 88.56 High High
Arthropathy 2 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Asn293 in transmembrane helix VI has also been proposed to be involved in the interaction of the beta-hydroxyl group of isoproterenol with the beta 2-adrenoceptor [4].
beta 2 Binding (interaction) of
1) Confidence 0.47 Published 1998 Journal Proc. West. Pharmacol. Soc. Section Abstract Doc Link 9836297 Disease Relevance 0 Pain Relevance 0.30
CONCLUSION: These changes in immunological and cardiovascular variables are considered to be elements of a sympatho-adrenal stress reaction; catecholamines are considered to induce a demargination of leukocytes by binding to beta2-adrenoceptors and by modifying the avidity state of adhesion molecules.


beta2 Binding (binding) of in leukocytes
2) Confidence 0.47 Published 2001 Journal Eur J Anaesthesiol Section Body Doc Link 11473556 Disease Relevance 0 Pain Relevance 0
Using a clonal cell line of human osteoclast precursors (FLG 29.1 cells), that after treatment with 12-O-tetradecanoyl phorbol 13-acetate (TPA) show many functional characteristics of osteoclasts, we demonstrated that catecholamines act as inducers of osteoclast maturation in vitro and as stimulators of osteoclast activity via the binding to beta 2 adrenergic receptors.
beta 2 Binding (binding) of in osteoclast associated with catecholamine
3) Confidence 0.47 Published 1996 Journal Osteoporos Int Section Abstract Doc Link 8845594 Disease Relevance 0 Pain Relevance 0.15
During norepinephrine release elecited by the arrival of nerve impulses, the neurotransmitter interacts with specific receptors (alpha1-, beta1-, beta2-adrenoceptors) located in the membrane of the postsynaptic cell to trigger the response of the effector organ.
beta2 Binding (interacts) of in nerve associated with neurotransmitter
4) Confidence 0.47 Published 1980 Journal Pharmacol. Rev. Section Abstract Doc Link 6267618 Disease Relevance 0 Pain Relevance 0.09
The effects of different opioid substances on isoproterenol and forskolin-stimulated cyclic AMP (cAMP) intracellular accumulation, and on the binding of 125I-pindodol (IPIN) to beta 2-adrenoceptors were studied in human mononuclear leukocytes (MNL).
beta 2 Binding (binding) of in leukocytes associated with opioid
5) Confidence 0.47 Published 1995 Journal Biomed. Pharmacother. Section Abstract Doc Link 7749077 Disease Relevance 0 Pain Relevance 0.77
There were also no significant relationships between these measurements of vascular responsiveness and plasma norepinephrine levels, alpha 2-adrenoceptor binding or platelets of beta 2-adrenoceptor binding of lymphocytes.
beta 2 Binding (binding) of in plasma
6) Confidence 0.47 Published 1995 Journal J. Vasc. Res. Section Abstract Doc Link 7873712 Disease Relevance 0.09 Pain Relevance 0.26
The density of beta 2-adrenoceptors and their affinity for l-isoproterenol were measured with 125ICYP, and adenylate cyclase activity was determined with alpha 32P-ATP in mononuclear lymphocytes of RH patients before and at 1, 7, and 14 days after the last PGE2 infusion.
beta 2 Binding (affinity) of in lymphocytes associated with hypertension
7) Confidence 0.36 Published 1992 Journal Am. J. Hypertens. Section Abstract Doc Link 1321638 Disease Relevance 0.37 Pain Relevance 0.07
Immunoreactivity for alpha 1 and beta 2/3 subunits of the GABAA receptor was intense within the magnocellular layers and more modest in the parvocellular layers and intercalated layers.
beta 2 Binding (Immunoreactivity) of
8) Confidence 0.36 Published 1996 Journal Vis. Neurosci. Section Abstract Doc Link 8737273 Disease Relevance 0 Pain Relevance 0.23
However, the number of beta 2-adrenoceptor binding sites as assessed by radioligand binding with 125I-labelled cyanopindolol was not changed.
beta 2 Binding (binding) of
9) Confidence 0.36 Published 1995 Journal Clin. Sci. Section Abstract Doc Link 7493443 Disease Relevance 0.92 Pain Relevance 0.31
The amyloid deposits found were resistant against potassium permanganate treatment and reacted with anti-human beta 2-microglobulin antibody.
beta 2 Binding (reacted) of associated with amyloid plaque
10) Confidence 0.36 Published 1987 Journal Am. J. Nephrol. Section Abstract Doc Link 3434597 Disease Relevance 0.99 Pain Relevance 0.16
It is concluded that the sympathetic nerve fibres of the human saphenous vein are endowed with facilitatory presynaptic beta 2-adrenoceptors.
beta 2 Binding (endowed) of in saphenous vein
11) Confidence 0.36 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2900473 Disease Relevance 0 Pain Relevance 0.36
Guanosine triphosphate appeared to lower the affinity of [3H]clonidine for its receptor. [3H]Dihydroalprenolol bound to three classes of sites: the beta 1-receptor, the beta 2-receptor and a receptor with low affinity which represented about 40% of the total binding, but which was probably a non-specific site; the beta 1/beta 2 ratio was 1/2.
beta 2 Spec (appeared) Binding (bound) of associated with clonidine
12) Confidence 0.36 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2859208 Disease Relevance 0.16 Pain Relevance 0.28
BACKGROUND: It is unclear whether modulation of inflammatory markers by glycoprotein IIb/IIIa receptor inhibition after percutaneous coronary intervention (PCI) is caused by an interaction with the alpha(v)beta3 and alpha(M)beta2 receptor or it correlates with ischemic events during PCI.
beta2 Binding (interaction) of associated with inflammatory marker
13) Confidence 0.35 Published 2003 Journal Am. Heart J. Section Abstract Doc Link 12679767 Disease Relevance 0.27 Pain Relevance 0.29
In radioligand binding experiments, mexiletine (10 microM-1 mM) concentration-dependently displaced the specific binding of [125I]cyanopindolol to human beta1- and beta2-adrenoceptors in the membrane fraction of the cells.
beta2 Binding (binding) of associated with mexiletine
14) Confidence 0.28 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.35
On the other hand, high concentration (300 microM and 1 mM) of lidocaine, another class Ib antiarrhythmic drug, partially displaced the specific binding of [125I]cyanopindolol to human beta1-adrenoceptor, whereas it did not affect the specific binding of [125I]cyanopindolol to human beta2- and beta3-adrenoceptors.
beta2 Binding (binding) of associated with lidocaine
15) Confidence 0.27 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.55
These results demonstrate that mexiletine blocks the binding of agonists to beta1- and beta2-adrenoceptors, and thereby attenuates the agonist-induced cAMP accumulation, and that the action of mexiletine as an antagonist of beta1- and beta2-adrenoceptors is independent of its antiarrhythmic property.
beta2 Binding (binding) of associated with antagonist, agonist and mexiletine
16) Confidence 0.27 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.71
For instance, nicotine has a Kd of 1 nM for alpha4-beta2 nAChR, but only 4 ?
beta2 Binding (has) of associated with nicotine
17) Confidence 0.19 Published 2002 Journal BMC Struct Biol Section Body Doc Link PMC65631 Disease Relevance 0.42 Pain Relevance 0.64
Similarly, acetylcholine and nicotine were docked into the agonist binding site at the alpha3-beta2, alpha4-beta4 and alpha7-alpha7 interfaces.
beta2 Binding (interfaces) of associated with nicotine and agonist
18) Confidence 0.19 Published 2002 Journal BMC Struct Biol Section Body Doc Link PMC65631 Disease Relevance 0 Pain Relevance 0.33
While the homology between AChBP and the nAChR subunits is relatively low (22 % sequence identity, for instance, between alpha4 and AChBP), and the overall model needs to be refined, 72% of the AChBP residues in contact with HEPES are identical in the alpha4-beta2 nAChR (Figure 1), and the predicted conformation of the agonist binding pocket of nAChR is expected to be accurate.
beta2 Binding (pocket) of associated with agonist
19) Confidence 0.19 Published 2002 Journal BMC Struct Biol Section Body Doc Link PMC65631 Disease Relevance 0 Pain Relevance 0.15
METHODS: Human cell transfectants expressing or lacking the transporter associated with antigen processing were used to determine the cell surface expression of B27 subtypes by flow cytometry with antibodies recognizing the B27 heterodimer or beta2-microglobulin (beta2m)-free heavy chains.
beta2m Binding (recognizing) of
20) Confidence 0.01 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 16200602 Disease Relevance 0.18 Pain Relevance 0

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