INT60995

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Context Info
Confidence 0.38
First Reported 1995
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.63
Pain Relevance 9.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
neurons 2
prefrontal 2
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 12 99.98 Very High Very High Very High
Enkephalin 33 99.68 Very High Very High Very High
Pain 11 99.64 Very High Very High Very High
fluoxetine 6 99.50 Very High Very High Very High
Dynorphin 16 99.44 Very High Very High Very High
Analgesic 10 99.10 Very High Very High Very High
antagonist 26 99.08 Very High Very High Very High
Dextromethorphan 8 98.82 Very High Very High Very High
Spinal cord 3 98.60 Very High Very High Very High
IPN 3 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 5 100.00 Very High Very High Very High
Pain 7 99.64 Very High Very High Very High
Inflammatory Pain 3 98.32 Very High Very High Very High
INFLAMMATION 2 90.76 High High
Manic Depressive Disorder 1 71.56 Quite High
Depression 3 70.64 Quite High
Hyperalgesia 1 67.20 Quite High
Psychosis 1 58.64 Quite High
Herpes Zoster 2 5.00 Very Low Very Low Very Low
Neuralgia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preventing activity-induced upregulation of Homer1a using shRNAs in mice in vivo exacerbates inflammatory pain.
Negative_regulation (Preventing) of Positive_regulation (upregulation) of Homer1a associated with ipn
1) Confidence 0.38 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16715092 Disease Relevance 0.87 Pain Relevance 1.04
These results demonstrate that some of the effects of cocaine on gene regulation are mediated via D1 receptor-dependent mechanisms, as evidenced by the absence of immediate-early gene induction in D1-deficient mice, whereas others also involve additional, non-D1 receptor mechanisms, as shown for substance P expression.
Negative_regulation (absence) of Positive_regulation (induction) of immediate-early gene associated with substance p and cocaine
2) Confidence 0.31 Published 1996 Journal Neuroscience Section Abstract Doc Link 8884777 Disease Relevance 0 Pain Relevance 0.53
Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models.
Negative_regulation (blocks) of Positive_regulation (activation) of immediate-early gene associated with nociception, analgesic, tolerance, dextromethorphan and opiate
3) Confidence 0.07 Published 1995 Journal Neurology Section Abstract Doc Link 8545027 Disease Relevance 0.25 Pain Relevance 0.97
Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models.
Negative_regulation (blocks) of Positive_regulation (activation) of immediate-early gene associated with nociception, analgesic, tolerance, dextromethorphan and opiate
4) Confidence 0.05 Published 1995 Journal Neurology Section Abstract Doc Link 8545027 Disease Relevance 0.25 Pain Relevance 0.97
We also show that subchronic fluoxetine and olanzapine exposure suppresses the induction of two immediate-early gene transcription factors (e.g., pCREB and FOS) that are associated with long-lasting changes in synaptic efficacy and structural modifications in the prefrontal cortex, piriform cortex, and hippocampus.
Negative_regulation (suppresses) of Positive_regulation (induction) of immediate-early gene in prefrontal associated with hippocampus and fluoxetine
5) Confidence 0.04 Published 2003 Journal Synapse Section Abstract Doc Link 14556240 Disease Relevance 0.26 Pain Relevance 0.69
Repeated treatment with D2 receptor antagonists produces increased enkephalin expression and diminished immediate-early gene inducibility in striatopallidal neurons, as well as behavioral effects that are attenuated compared to those of acute treatment (e.g., reduced akinesia).
Negative_regulation (diminished) of Positive_regulation (inducibility) of immediate-early gene in neurons associated with antagonist and enkephalin
6) Confidence 0.03 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.49
Moreover, the present findings suggest that increased enkephalin expression after repeated D2 receptor antagonist treatment is an adaptive response that counteracts functional consequences of D2 receptor blockade, but is not involved in suppressed immediate-early gene induction.
Negative_regulation (suppressed) of Positive_regulation (induction) of immediate-early gene associated with antagonist and enkephalin
7) Confidence 0.03 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 0.94
Intrastriatal infusion of enkephalin (delta and mu), but not dynorphin (kappa), receptor agonists suppressed immediate-early gene induction by eticlopride in a dose-dependent manner.
Negative_regulation (suppressed) of Positive_regulation (induction) of immediate-early gene associated with dynorphin, agonist and enkephalin
8) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.68
Naloxone reversed such behavioral recovery (i.e. reinstated akinesia), but did not significantly affect suppressed immediate-early gene induction.
Neg (not) Negative_regulation (suppressed) of Neg (not) Positive_regulation (induction) of immediate-early gene associated with narcan
9) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.33

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