INT60999

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Context Info
Confidence 0.74
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.28
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
endothelial cells 2
myocardium 1
peripheral nerve 1
vessels 1
endothelium 1
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 15 96.52 Very High Very High Very High
Sciatic nerve 1 95.32 Very High Very High Very High
Eae 1 94.40 High High
headache 5 94.36 High High
hyperexcitability 1 92.80 High High
Stimulus evoked pain 2 90.92 High High
Bioavailability 3 90.64 High High
Neurotransmitter 4 89.08 High High
Rostral ventrolateral medulla 2 87.08 High High
metalloproteinase 26 86.68 High High
Disease Link Frequency Relevance Heat
Natriuresis 4 100.00 Very High Very High Very High
Stress 68 99.48 Very High Very High Very High
Nervous System Injury 36 98.52 Very High Very High Very High
Cv Unclassified Under Development 29 96.52 Very High Very High Very High
Pressure And Volume Under Development 4 96.44 Very High Very High Very High
Adhesions 8 96.36 Very High Very High Very High
Increased Venous Pressure Under Development 28 96.24 Very High Very High Very High
Vasculitis 2 94.80 High High
Injury 15 94.40 High High
Headache 2 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, we demonstrated a novel redox mechanism in IP-induced eNOS and GLUT-4 translocation and the role of caveolar paradox in making the heart euglycemic during the process of ischemia, leading to myocardial protection in a clinically relevant rat ischemic model.
Localization (translocation) of eNOS in heart associated with ischemia
1) Confidence 0.74 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.23 Pain Relevance 0.18
It clearly documents a significant role of ROS signaling in Akt/eNOS/Cav-3-mediated GLUT-4 translocation and association in IP myocardium.
Localization (translocation) of eNOS in myocardium
2) Confidence 0.74 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.15 Pain Relevance 0.19
Immunohistochemical localization of endothelial nitric oxide synthase in vessels of the dura mater of the Sprague-Dawley rat.
Localization (localization) of endothelial nitric oxide synthase in vessels
3) Confidence 0.70 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 8545062 Disease Relevance 0.26 Pain Relevance 0.32
NO release by vascular endothelial cells via endothelial NO synthase (eNOS) leads to the relaxation of vascular smooth muscle, mainly by activating cyclic guanosine monophosphate (cGMP) [26].
Localization (release) of endothelial NO synthase in endothelial cells
4) Confidence 0.64 Published 2009 Journal J Ovarian Res Section Body Doc Link PMC2633338 Disease Relevance 0.21 Pain Relevance 0
NO release by vascular endothelial cells via endothelial NO synthase (eNOS) leads to the relaxation of vascular smooth muscle, mainly by activating cyclic guanosine monophosphate (cGMP) [26].
Localization (release) of eNOS in endothelial cells
5) Confidence 0.64 Published 2009 Journal J Ovarian Res Section Body Doc Link PMC2633338 Disease Relevance 0.22 Pain Relevance 0
Quantification of eNOS and nNOS proteins
Localization (Quantification) of eNOS
6) Confidence 0.40 Published 2010 Journal Int J Impot Res Section Body Doc Link PMC2959156 Disease Relevance 0.59 Pain Relevance 0
However, NO shows a dual behavior: at physiological concentrations, released through the constitutive synthase (cNOS), it regulates house-keeping functions, whereas its overproduction by the inducible isoenzyme (iNOS) exhibits cytotoxic activity because interacting with reactive species producing peroxinitrites (ONOO) and other compounds, which are highly damaging for the tissues.
Localization (released) of cNOS
7) Confidence 0.39 Published 2001 Journal Curr. Pharm. Des. Section Abstract Doc Link 11472246 Disease Relevance 0 Pain Relevance 0.04
Furthermore, nuclear translocation of VEGFR-2 along with caveolin-1 and eNOS was reported to occur following VEGF treatment [39].
Localization (translocation) of eNOS
8) Confidence 0.31 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC519024 Disease Relevance 0.50 Pain Relevance 0
The action of these drugs are based upon intact NO releasing neural fibers (nNOS) and corporal endothelium (eNOS).
Neg (NO) Localization (releasing) of eNOS in endothelium
9) Confidence 0.25 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 0.96 Pain Relevance 0.17
Using immunohistochemical methods we provide evidence for a unique endothelial constitutive nitric oxide synthase (ecNOS) immunoreactivity localized in early axonal endbulb-like structures of injured peripheral nerve axons.
Localization (localized) of ecNOS in peripheral nerve
10) Confidence 0.16 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10947811 Disease Relevance 1.00 Pain Relevance 0.56
An increase in vasodilator proteins such as kallikrein, eNOS, and atrial natriuretic peptide (ANP) in animal
Localization (natriuretic peptide) of eNOS associated with natriuresis
11) Confidence 0.12 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.59 Pain Relevance 0.04
Local eNOS
Localization (Local) of eNOS
12) Confidence 0.12 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.57 Pain Relevance 0.24

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