INT610

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1976
Last Reported 2010
Negated 1
Speculated 3
Reported most in Title
Documents 47
Total Number 51
Disease Relevance 14.17
Pain Relevance 31.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PENK) extracellular region (PENK)
Anatomy Link Frequency
neurons 2
astrocyte 2
caudate nucleus 1
CSF 1
brain 1
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 499 100.00 Very High Very High Very High
Enkephalin 345 100.00 Very High Very High Very High
Neurotransmitter 63 100.00 Very High Very High Very High
Pain 27 100.00 Very High Very High Very High
Opioid 26 100.00 Very High Very High Very High
dexamethasone 12 100.00 Very High Very High Very High
narcan 9 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
cytokine 2 100.00 Very High Very High Very High
Bioavailability 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 46 100.00 Very High Very High Very High
Pain 28 100.00 Very High Very High Very High
Prostate Cancer 7 99.84 Very High Very High Very High
Syndrome 1 99.36 Very High Very High Very High
Disease 64 99.30 Very High Very High Very High
Neuroblastoma 3 99.28 Very High Very High Very High
Impaired Glucose Tolerance 8 99.00 Very High Very High Very High
Schizophrenia 6 99.00 Very High Very High Very High
Glioma 3 98.72 Very High Very High Very High
Pheochromocytoma 26 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent evidence has indicated that hairpin formation within this region may be involved in transcriptional regulation of the human proenkephalin gene.
Regulation (regulation) of proenkephalin gene
1) Confidence 0.62 Published 1994 Journal Biochemistry Section Abstract Doc Link 7918414 Disease Relevance 0 Pain Relevance 0.16
Depletion of endogenous noradrenaline following unilateral lesions of the VNAB did not affect the CRF mRNA or the proenkephalin A mRNA response to stress.
Regulation (response) of proenkephalin A associated with stress and noradrenaline
2) Confidence 0.60 Published 1991 Journal Brain Res. Section Abstract Doc Link 1655164 Disease Relevance 0.49 Pain Relevance 0.16
Possible autocrine enkephalin regulation of catecholamine release in human pheochromocytoma cells.
Regulation (regulation) of enkephalin associated with catecholamine, enkephalin and pheochromocytoma
3) Confidence 0.54 Published 2008 Journal Life Sci. Section Title Doc Link 18706432 Disease Relevance 0.38 Pain Relevance 0.75
Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.
Regulation (Alterations) of proenkephalin in putamen associated with enkephalin and disease
4) Confidence 0.52 Published 2007 Journal J. Neurosci. Res. Section Title Doc Link 17203488 Disease Relevance 0.55 Pain Relevance 0.38
Furthermore, enkephalin responses appear to be modulated by gamma-aminobutyric acid complexes, in that the reversal of the excitatory hemodynamic responses seen in the conscious state to vasodepressor responses after barbiturate anesthesia may result from alteration of the state of activation of the gamma-aminobutyric acid complex.
Regulation (modulated) of enkephalin associated with anesthesia and enkephalin
5) Confidence 0.51 Published 1989 Journal Am. J. Cardiol. Section Abstract Doc Link 2547299 Disease Relevance 0.05 Pain Relevance 0.64
Our results provide information which could lead to the rational design of agents capable to modulate the bioavailability of enkephalin and other endogenous aminopeptidase-degraded peptides believed to be involved in the etiology and/or pathophysiology associated with various disease conditions.
Regulation (modulate) of enkephalin associated with enkephalin, disease and bioavailability
6) Confidence 0.51 Published 2003 Journal Pharmacology Section Abstract Doc Link 12444298 Disease Relevance 0.09 Pain Relevance 0.42
In the striatum, mRNA levels were significantly higher in COMT Met(108/158) homozygous cases indicating that MOP binding sites and enkephalin are regulated in parallel.
Regulation (regulated) of enkephalin in striatum associated with catechol-o-methyltransferase, enkephalin and opioid
7) Confidence 0.50 Published 2005 Journal Neuroimage Section Abstract Doc Link 16040257 Disease Relevance 0.05 Pain Relevance 1.22
Effects of the synthetic enkephalin analogue FK 33-824 on pain threshold and pain tolerance in man.
Regulation (Effects) of enkephalin associated with pain, pain threshold, tolerance and enkephalin
8) Confidence 0.45 Published 1979 Journal Pain Section Title Doc Link 523172 Disease Relevance 0.51 Pain Relevance 1.68
[Effect of a synthetic analog of enkephalin on the choreic syndrome].
Regulation ([Effect) of enkephalin associated with syndrome and enkephalin
9) Confidence 0.45 Published 1982 Journal Rev. Neurol. (Paris) Section Title Doc Link 6762632 Disease Relevance 0.19 Pain Relevance 0.19
We have investigated the effects of unilateral ventral noradrenergic bundle (VNAB) lesions on corticotrophin-releasing factor (CRF) and proenkephalin A mRNA responses in the parvocellular paraventricular nucleus (pPVN) to both physical and psychological stresses.
Regulation (responses) of proenkephalin A in nucleus associated with stress
10) Confidence 0.44 Published 1991 Journal Brain Res. Section Abstract Doc Link 1655164 Disease Relevance 0.41 Pain Relevance 0.12
Nitric oxide alters proenkephalin and prodynorphin gene expression in hippocampal granule cells.
Regulation (alters) of proenkephalin in hippocampal granule cells associated with enkephalin
11) Confidence 0.44 Published 1994 Journal Neuroscience Section Title Doc Link 7969920 Disease Relevance 0 Pain Relevance 0.25
We have examined the effects of localised administration of the synthetic glucocorticoid dexamethasone on basal and stress-induced levels of mRNA for both corticotrophin-releasing factor (CRF) and proenkephalin A, in parvocellular neurons of the paraventricular nucleus (PVN).
Spec (examined) Regulation (effects) of proenkephalin A in neurons associated with stress and dexamethasone
12) Confidence 0.44 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.38 Pain Relevance 0.09
Glucocorticoid inhibition of stress-induced changes in hypothalamic corticotrophin-releasing factor messenger RNA and proenkephalin A messenger RNA.
Regulation (changes) of proenkephalin A associated with stress and enkephalin
13) Confidence 0.44 Published 1989 Journal Neuropeptides Section Title Doc Link 2789345 Disease Relevance 0.42 Pain Relevance 0.25
Further analyses showed no differences in mRNA levels, for pENK, pDYN, or GAD67 mRNA, between PD patients and aged matched controls.
Neg (no) Regulation (differences) of pENK associated with disease
14) Confidence 0.43 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17203488 Disease Relevance 0.77 Pain Relevance 0.20
Glucocorticoids and cyclic AMP synergistically regulate the abundance of preproenkephalin messenger RNA in neuroblastoma-glioma hybrid cells.
Regulation (regulate) of preproenkephalin associated with neuroblastoma, enkephalin and glioma
15) Confidence 0.42 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 3021119 Disease Relevance 0.39 Pain Relevance 0.21
We have examined the distribution of leucine enkephalin (LENK) and substance P (SP) immunoreactivity in relation to striosomes defined by calbindin-D (CABD) staining in alternate 70 microns serial sections from the human caudate nucleus.
Spec (examined) Regulation (distribution) of leucine enkephalin in caudate nucleus associated with enkephalin and substance p
16) Confidence 0.41 Published 1994 Journal J. Chem. Neuroanat. Section Abstract Doc Link 7531455 Disease Relevance 0 Pain Relevance 0.61
The effect of enkephalin analogue on pituitary hormone release in human obesity.
Regulation (effect) of enkephalin in pituitary associated with obesity and enkephalin
17) Confidence 0.39 Published 1987 Journal Horm. Metab. Res. Section Title Doc Link 3104184 Disease Relevance 0.85 Pain Relevance 0.36
Down-regulation of PENK in prostate cancer
Regulation (regulation) of PENK associated with prostate cancer
18) Confidence 0.38 Published 2005 Journal BMC Urol Section Body Doc Link PMC1327674 Disease Relevance 0.57 Pain Relevance 0.15
Effect of enkephalin and naloxone on vagal and hormonal stimulation of pancreatic secretion in man.
Regulation (Effect) of enkephalin associated with narcan and enkephalin
19) Confidence 0.35 Published 1983 Journal Scand. J. Gastroenterol. Section Title Doc Link 6372071 Disease Relevance 0 Pain Relevance 0.70
Effects of orthodontic force on methionine enkephalin and substance P concentrations in human pulpal tissue.
Regulation (Effects) of enkephalin associated with enkephalin and substance p
20) Confidence 0.30 Published 1989 Journal Am J Orthod Dentofacial Orthop Section Title Doc Link 2471405 Disease Relevance 0 Pain Relevance 0.83

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox