INT61011

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Context Info
Confidence 0.22
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.17
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPH1) small molecule metabolic process (TPH1) cellular nitrogen compound metabolic process (TPH1)
response to stress (TPH1)
Anatomy Link Frequency
chemosensory neurons 1
TPH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 10 100.00 Very High Very High Very High
Clonidine 4 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
agonist 1 100.00 Very High Very High Very High
Migraine 5 99.92 Very High Very High Very High
monoamine 2 99.92 Very High Very High Very High
Serotonin 16 99.44 Very High Very High Very High
Calcium channel 6 99.24 Very High Very High Very High
Pain 1 98.96 Very High Very High Very High
Catecholamine 1 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 5 99.92 Very High Very High Very High
Stress 4 99.80 Very High Very High Very High
Somatoform Disorder 1 98.96 Very High Very High Very High
Depression 39 91.84 High High
Congenital Anomalies 4 90.12 High High
Convulsion 1 88.72 High High
Frailty 1 84.96 Quite High
Toxicity 1 83.60 Quite High
Targeted Disruption 1 62.40 Quite High
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The voltage-gated calcium channel UNC-2 is involved in stress-mediated regulation of tryptophan hydroxylase.
Regulation (regulation) of tryptophan hydroxylase associated with stress and calcium channel
1) Confidence 0.22 Published 2004 Journal J. Neurochem. Section Title Doc Link 14675154 Disease Relevance 0.55 Pain Relevance 0.53
Most of these studies focus on candidate genes related to monoamine function, including the serotonin transporter (the molecular target for SSRIs), tryptophan hydroxylase-1, monoamine oxidase A, and the type 2A serotonin receptor.
Regulation (target) of tryptophan hydroxylase-1 associated with ssri, serotonin and monoamine
2) Confidence 0.04 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2965366 Disease Relevance 0.18 Pain Relevance 0.62
Previously, we have shown that in the ADF chemosensory neurons of Caenorhabditis elegans UNC-2/Ca(2+) channel function affects TGF-beta-dependent developmental regulation of tryptophan hydroxylase, the rate-limiting enzyme in serotonin synthesis.
Regulation (regulation) of tryptophan hydroxylase in chemosensory neurons associated with serotonin
3) Confidence 0.02 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16860310 Disease Relevance 0.45 Pain Relevance 0.44
As the catecholamines have long been implicated in attentional processes, the present investigation compared the effects of the mixed alpha 1/alpha 2 adrenoceptor agonist clonidine (CLO), the benzodiazepine diazepam (DZP), the D1/D2 antagonist haloperidol (HAL) and a low-tryptophan drink (Lo-TRP) on performance of tests of selective attention with distractors in four groups of young, healthy volunteers.
Regulation (effects) of low-tryptophan drink associated with antagonist, catecholamine, agonist and clonidine
4) Confidence 0.00 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8545528 Disease Relevance 0 Pain Relevance 0.50

General Comments

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