INT61025

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.15
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
melanocyte 2
amniotic fluid 2
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 4 100.00 Very High Very High Very High
cytokine 5 95.20 Very High Very High Very High
antagonist 1 83.52 Quite High
Hyperalgesia 2 76.00 Quite High
Intracerebroventricular 11 75.00 Quite High
Thermal hyperalgesia 1 75.00 Quite High
agonist 2 56.48 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 28 98.16 Very High Very High Very High
Hypersensitivity Vasculitis 4 97.88 Very High Very High Very High
Congenital Anomalies 1 86.24 High High
Dysmenorrhea 1 84.32 Quite High
Nociception 1 77.12 Quite High
Hyperalgesia 4 76.00 Quite High
Chromosome Aberrations 1 50.00 Quite Low
Obesity 78 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rhIL-6 (30 ng)-induced reduction of the paw-withdrawal latency was completely blocked by the co-injection of either Na salicylate (30 ng, LCV) or alpha-melanocyte stimulating hormone (30 ng, LCV), an anti-cytokine substance.
Negative_regulation (blocked) of Negative_regulation (reduction) of rhIL-6 in melanocyte associated with hypersensitivity vasculitis, withdrawal and cytokine
1) Confidence 0.43 Published 1995 Journal Brain Res. Section Abstract Doc Link 8548295 Disease Relevance 0.66 Pain Relevance 0.53
IL-6 and we observed that IL-6 reduction of food intake was reversed by Rapamycin.
Negative_regulation (reversed) of Negative_regulation (reduction) of IL-6
2) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.18 Pain Relevance 0
IL-6 and we observed that IL-6 reduction of food intake was reversed by AG490 (Figure 2f).


Negative_regulation (reversed) of Negative_regulation (reduction) of IL-6
3) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.15 Pain Relevance 0.03
RESULTS: An increase of interleukin-6 (P = 0.034) and a decrease of interleukin-8 (P < or =0.0001) in amniotic fluid, and a decrease of interleukin-6 in the maternal plasma (P = 0.026) was shown in pregnancies with fetal chromosomal abnormalities.
Negative_regulation (decrease) of Negative_regulation (decrease) of interleukin-6 in amniotic fluid
4) Confidence 0.13 Published 2002 Journal Hum. Reprod. Section Body Doc Link 11870140 Disease Relevance 0.17 Pain Relevance 0

General Comments

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