INT61036

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 7.45
Pain Relevance 4.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) nucleolus (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
plasma 2
coronary sinus 1
plaque 1
epithelial cell 1
Selp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 55 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 7 99.56 Very High Very High Very High
ischemia 4 97.56 Very High Very High Very High
Pain 2 97.16 Very High Very High Very High
withdrawal 7 88.32 High High
noradrenaline 3 87.08 High High
Inflammatory marker 7 85.32 High High
headache 1 82.80 Quite High
cINOD 5 75.44 Quite High
aspirin 14 74.72 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 40 100.00 Very High Very High Very High
Sleep Disorders 3 99.56 Very High Very High Very High
Myocardial Infarction 27 99.40 Very High Very High Very High
Stable Angina Pectoris 14 98.40 Very High Very High Very High
Cv Unclassified Under Development 2 97.56 Very High Very High Very High
Sickle Cell Anemia 3 96.12 Very High Very High Very High
Necrosis 2 95.88 Very High Very High Very High
Adhesions 11 95.48 Very High Very High Very High
Coronary Artery Disease 5 88.60 High High
Dyslipidemia /

Combined Dyslipidemia

1 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This novel finding suggests that P-selectin inhibition be considered as a potential approach to therapy for the treatment of painful vaso-occlusion in sickle cell disease.
Negative_regulation (inhibition) of P-selectin associated with sickle cell anemia and pain
1) Confidence 0.50 Published 2001 Journal Blood Section Abstract Doc Link 11535535 Disease Relevance 0.43 Pain Relevance 0.15
In both AMI and UA, S-nitrosoglutathione reduced P-selectin (P < .001) and glycoprotein IIb/IIIa (P < .05) expression, as did glyceryl trinitrate (P < .02 and P < .01, respectively).
Negative_regulation (reduced) of P-selectin associated with angina and myocardial infarction
2) Confidence 0.40 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8548426 Disease Relevance 1.57 Pain Relevance 0.88
The blocking ICAM-1 and P-selectin MAbs both inhibited Indo-induced increases in lesion score, mucosal permeability, and epithelial cell necrosis.
Negative_regulation (blocking) of P-selectin in epithelial cell associated with necrosis
3) Confidence 0.39 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486176 Disease Relevance 0.58 Pain Relevance 0.39
Plasma P-selectin was decreased by direct PTCA in all of the 20 patients with AMI (from 176.2 +/- 17.7 ng/mL to 141.7 +/- 12.6 ng/mL; p<0.001, paired t-test), whereas it was increased by thrombolysis using TPA in nine of the 10 AMI patients (from 177.4 +/- 17.2 ng/mL to 248.8 +/- 17.3 ng/mL, p<0.005).
Negative_regulation (decreased) of P-selectin in Plasma associated with myocardial infarction and percutaneous transluminal coronary angioplasty
4) Confidence 0.36 Published 1998 Journal Angiology Section Abstract Doc Link 9783645 Disease Relevance 1.10 Pain Relevance 0.56
However, both PAG rate and P-selectin level decreased to a greater extent in the trial group than in the control group after treatment, and the difference between treatment was significant (both p<0.05).
Negative_regulation (decreased) of P-selectin
5) Confidence 0.29 Published 2007 Journal J Altern Complement Med Section Body Doc Link 17604562 Disease Relevance 0 Pain Relevance 0
However, both the PAG rate and P-selectin level decreased to a greater extent in the trial group than in the control group after treatment, and the difference between the two groups was significant (both p < 0.05).
Negative_regulation (decreased) of P-selectin
6) Confidence 0.29 Published 2007 Journal J Altern Complement Med Section Body Doc Link 17480139 Disease Relevance 0 Pain Relevance 0
[Decreased plasma soluble P-selectin level in coronary sinus after successful coronary angioplasty in patients with unstable angina].
Negative_regulation (Decreased) of P-selectin in coronary sinus associated with angina
7) Confidence 0.20 Published 1999 Journal J Cardiol Section Title Doc Link 10354952 Disease Relevance 0.43 Pain Relevance 0.33
Increased plasma soluble P-selectin (159.7 +/- 74.5 vs 78.7 +/- 26.4 ng/ml, p < 0.01) and PF-4 (456.5 +/- 87.0 vs 118.7 +/- 62.3 IU/ml, p < 0.01) levels were found in patients with unstable angina compared with those in controls, and were significantly decreased after angioplasty (147.8 +/- 69.6 ng/ml, p < 0.05; 401.6 +/- 108.5 IU/ml, p < 0.05), whereas von Willebrand factor antigen was unchanged.
Negative_regulation (decreased) of P-selectin in plasma associated with angina
8) Confidence 0.20 Published 1999 Journal J Cardiol Section Abstract Doc Link 10354952 Disease Relevance 0.53 Pain Relevance 0.47
Endothelial function improved progressively and C-reactive protein, P-selectin, and tissue plasminogen activator inhibitor levels decreased, but there was no decrease in exercise electrocardiographic ischemia.
Negative_regulation (decreased) of P-selectin associated with ischemia
9) Confidence 0.08 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 14609594 Disease Relevance 0.42 Pain Relevance 0.29
P-selectin levels, on the other hand, appeared to increase slightly two weeks after clopidogrel cessation (from 44 to 50 ng/ml; P < 0.001) and then decreased to the baseline levels (45 ng/ml; P = 0.488) after 4 weeks (Table 3B).
Negative_regulation (decreased) of P-selectin
10) Confidence 0.07 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.64 Pain Relevance 0.28
In conclusion, determination of serum VCAM-1, E-selectin and P-selectin levels seems more useful for detecting coronary plaque destabilization.
Negative_regulation (determination) of P-selectin in plaque
11) Confidence 0.05 Published 2004 Journal Int. J. Cardiol. Section Abstract Doc Link 15262039 Disease Relevance 1.37 Pain Relevance 0.92
Sedation before interventions reduces sP-selectin levels, initial phase of coagulation and, consequently, myocardial damage.
Negative_regulation (reduces) of sP-selectin associated with sleep disorders
12) Confidence 0.04 Published 2006 Journal Int. J. Clin. Pract. Section Abstract Doc Link 16700848 Disease Relevance 0.30 Pain Relevance 0.18

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