INT61041

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Context Info
Confidence 0.63
First Reported 1995
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.39
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Tpsab1) extracellular region (Tpsab1)
Anatomy Link Frequency
gut 2
Tpsab1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 1 95.76 Very High Very High Very High
Morphine 2 87.04 High High
algil 4 50.00 Quite Low
Inflammation 2 50.00 Quite Low
Pain 3 10.00 Low Low
Codeine 2 10.00 Low Low
spastic colon 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 1 99.72 Very High Very High Very High
Death 2 75.88 Quite High
Shock 1 75.00 Quite High
INFLAMMATION 1 60.20 Quite High
Stress 2 50.00 Quite Low
Allergic Dermatitis 1 50.00 Quite Low
Mucositis 1 50.00 Quite Low
Functional Bowel Disorder 1 5.00 Very Low Very Low Very Low
Anaphylaxis 1 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No correlation was found between the IgE levels and tryptase in either group, supporting the hypothesis that tryptase release was not mediated by an allergic reaction.
Neg (not) Positive_regulation (mediated) of Localization (release) of tryptase associated with hypersensitivity
1) Confidence 0.63 Published 1997 Journal Allergy Section Abstract Doc Link 9298181 Disease Relevance 0.33 Pain Relevance 0.26
RESULTS: Although a significant accumulation of histamine was found in inflamed IBD-tissue, the results indicate, however, that this premedication does not enhance the release of histamine or tryptase from gut mucosal samples, neither in the histologically normal mucosa of control persons nor in tissue unaffected or affected by inflammatory bowel disease.
Neg (not) Positive_regulation (enhance) of Localization (release) of tryptase in gut
2) Confidence 0.60 Published 1995 Journal Endoscopy Section Body Doc Link 8549437 Disease Relevance 0 Pain Relevance 0
Epithelial response in both groups was associated with similar increases in luminal tryptase and alpha-defensins release.
Positive_regulation (increases) of Localization (release) of tryptase
3) Confidence 0.34 Published 2008 Journal Gastroenterology Section Body Doc Link 18455999 Disease Relevance 0 Pain Relevance 0
Injection of allergen, but not buffer controls, induced a significant release of histamine, tryptase, prostaglandin D(2), total protein, and eosinophilic cationic protein.
Positive_regulation (induced) of Localization (release) of tryptase
4) Confidence 0.14 Published 2001 Journal Clin. Exp. Allergy Section Body Doc Link 11591187 Disease Relevance 0.06 Pain Relevance 0

General Comments

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