INT61049

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Context Info
Confidence 0.21
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1) plasma membrane (Oprd1)
cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 6
Oprd1 (Rattus norvegicus)
Odc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 16 100.00 Very High Very High Very High
mu opioid receptor 4 100.00 Very High Very High Very High
Endogenous opioid 4 97.04 Very High Very High Very High
Delta opioid receptors 2 87.12 High High
antagonist 6 77.60 Quite High
Central nervous system 2 75.00 Quite High
Intracerebroventricular 2 52.32 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results obtained demonstrate that i.c.v. beta-endorphin downregulates ODC expression in central as well as in peripheral tissues by interacting with brain mu-opioid receptors, but not with delta- or epsilon-opioid receptors or mu/delta-opioid receptor complexes.
opioid receptor Binding (interacting) of in brain Negative_regulation (downregulates) of Gene_expression (expression) of ODC in brain associated with mu opioid receptor and opioid receptor
1) Confidence 0.21 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549635 Disease Relevance 0 Pain Relevance 0.82
The results obtained demonstrate that i.c.v. beta-endorphin downregulates ODC expression in central as well as in peripheral tissues by interacting with brain mu-opioid receptors, but not with delta- or epsilon-opioid receptors or mu/delta-opioid receptor complexes.
epsilon-opioid Binding (interacting) of in brain Negative_regulation (downregulates) of Gene_expression (expression) of ODC in brain associated with mu opioid receptor and opioid receptor
2) Confidence 0.21 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549635 Disease Relevance 0 Pain Relevance 0.82

General Comments

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