INT61066

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Context Info
Confidence 0.77
First Reported 1996
Last Reported 2009
Negated 4
Speculated 1
Reported most in Body
Documents 55
Total Number 59
Disease Relevance 2.01
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Igfbp2) extracellular space (Igfbp2) aging (Igfbp2)
extracellular region (Igfbp2) response to stress (Igfbp2)
Anatomy Link Frequency
osteocytes 10
shaft 7
osteoblasts 7
brain 4
tibia 3
Igfbp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 102 97.76 Very High Very High Very High
Clonidine 2 96.00 Very High Very High Very High
anesthesia 59 91.36 High High
isoflurane 63 90.08 High High
antagonist 40 79.36 Quite High
Inflammatory response 20 77.12 Quite High
ischemia 4 71.20 Quite High
Inflammation 35 70.96 Quite High
alcohol 102 66.92 Quite High
Neurotransmitter 12 56.76 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 51 99.68 Very High Very High Very High
Bordatella Infection 12 99.64 Very High Very High Very High
Endotoxemia 8 87.84 High High
Hypophysis Disease 1 83.16 Quite High
Sprains And Strains 102 77.16 Quite High
INFLAMMATION 54 76.72 Quite High
Sepsis 152 71.72 Quite High
Cv Unclassified Under Development 4 71.20 Quite High
Pneumonia 4 70.96 Quite High
Temporomandibular Joint Disorders 15 68.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fig. 1Expression of IGFBP-2 mRNA in rat brain sections (A, B) and in longitudinal control (C-G), sham-loaded (H), and loaded (J) tibial sections of 12-week-old female Wistar rats.
Gene_expression (1Expression) of IGFBP-2 mRNA in brain
1) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0.03
In summary, this study shows an increase of the number of osteocytes at the endosteal side of the shaft and inner lamellae expressing IGFBP-2 mRNA 6 hours after mechanical loading and sham loading in vivo.
Gene_expression (expressing) of IGFBP-2 mRNA in shaft
2) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0.06 Pain Relevance 0.04
No differences of IGFBP-2 mRNA expression between the right and left tibiae of the control group were observed using semiquantitative analysis.
Gene_expression (expression) of IGFBP-2 mRNA
3) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0.03
IGFBP-2 mRNA expression was restricted to this area and was not observed in the osteocytes at the periosteal side of the shaft.
Gene_expression (expression) of IGFBP-2 mRNA in shaft
4) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
In control tibiae, IGFBP-2 mRNA was expressed in osteoblasts, which were situated against the surface of trabecular bone (Fig. 1C, E) and the endosteal side of the shaft (Fig. 1G).
Gene_expression (expressed) of IGFBP-2 mRNA in osteoblasts
5) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0.05
Therefore, a second quantitative evaluation of the endocortical osteocytes expressing IGFBP-2 mRNA was performed with Lucia G Version 4.82 (Uvikon) using coded slides of sections II and III.
Gene_expression (expressing) of IGFBP-2 mRNA in osteocytes
6) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0.06 Pain Relevance 0.03
This in vivo study showed an increase in the number of endocortical osteocytes expressing IGFBP-2 mRNA in loaded (1.68-fold) and sham-loaded (1.35-fold) tibiae 6 hours after a single period of mechanical loading with the four-point bending system.
Gene_expression (expressing) of IGFBP-2 mRNA in osteocytes
7) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
The upregulation of IGFBP-2 mRNA expression was restricted to osteocytes at the endosteal side of the shaft and multiple inner lamellae.
Gene_expression (expression) of IGFBP-2 mRNA in shaft
8) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
(J) IGFBP-2 mRNA expression in the endocortical osteocytes within multiple layers (indicated by arrowheads) and osteoblasts of a loaded tibia.
Gene_expression (expression) of IGFBP-2 mRNA in osteoblasts
9) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
It was demonstrated that the IGFBP-2 probe is specific because IGFBP-2 mRNA expression is present in the choroid plexus and the neurons of the medulla oblongata, as described earlier [28], and in the chondrocytes of the proliferative and hypertrophic zone of the growth plate [34].
Gene_expression (expression) of IGFBP-2 mRNA in chondrocytes associated with medulla
10) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0.08 Pain Relevance 0.05
Mechanical stimulation modulates IGFBP-2 mRNA expression in endocortical osteocytes.
Gene_expression (expression) of IGFBP-2 mRNA in osteocytes
11) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Abstract Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
The endocortical osteocytes, which were located within the deeper lamellae (Fig. 1G), and the periosteal osteocytes (Fig. 1D) did not express IGFBP-2 mRNA.
Neg (not) Gene_expression (express) of IGFBP-2 mRNA in osteocytes
12) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0.04
Megakaryocytes, macrophages, and myeloid cells also expressed IGFBP-2 mRNA.
Gene_expression (expressed) of IGFBP-2 mRNA in myeloid cells
13) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Abstract Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
The control brain showed IGFBP-2 mRNA expression in the choroid plexus (Fig. 1A) and the neurons of the medulla oblongata (data not shown).
Gene_expression (expression) of IGFBP-2 mRNA in choroid plexus associated with medulla
14) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0.05
We conclude that bending and squeezing of rat tibiae result in an increase of locally synthesized IGFBP-2 mRNA by endocortical osteocytes.
Gene_expression (synthesized) of IGFBP-2 mRNA in osteocytes
15) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
(D) IGFBP-2 mRNA expression in the periosteum of a control tibia; the osteocytes in the periosteal side of the shaft do not express IGFBP-2 mRNA.
Gene_expression (expression) of IGFBP-2 mRNA in tibia
16) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
Some cells of the bone marrow, i.e., megakaryocytes, macrophages, and myeloid cells, also expressed IGFBP-2 mRNA (Fig. 1E).
Gene_expression (expressed) of IGFBP-2 mRNA in macrophages
17) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0.03
(D) IGFBP-2 mRNA expression in the periosteum of a control tibia; the osteocytes in the periosteal side of the shaft do not express IGFBP-2 mRNA.
Neg (not) Gene_expression (express) of IGFBP-2 mRNA in tibia
18) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
(E) IGFBP-2 mRNA expression in osteoblasts situated against the surface of normal trabecular bone and IGFBP-2-positive bone marrow cells.
Gene_expression (expression) of IGFBP-2 mRNA in bone marrow
19) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0
No difference between IGFBP-2 mRNA expression in the left and right control tibia was observed.
Gene_expression (expression) of IGFBP-2 mRNA in tibia
20) Confidence 0.77 Published 2007 Journal Calcif Tissue Int Section Body Doc Link PMC1914289 Disease Relevance 0 Pain Relevance 0

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