INT61068

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 8.48
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp3) nucleus (Igfbp3)
Anatomy Link Frequency
neurons 2
blood 1
hypothalamus 1
spine 1
fibroblasts 1
Igfbp3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 15 99.60 Very High Very High Very High
Bioavailability 6 99.00 Very High Very High Very High
medulla 8 96.68 Very High Very High Very High
Clonidine 6 96.00 Very High Very High Very High
anesthesia 11 92.32 High High
ketamine 4 89.68 High High
cytokine 31 77.60 Quite High
chemokine 29 76.80 Quite High
cocaine 4 69.04 Quite High
Inflammation 30 65.84 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 176 100.00 Very High Very High Very High
Osteoporosis 24 100.00 Very High Very High Very High
Stomach Cancer 232 99.84 Very High Very High Very High
Gastritis 28 99.28 Very High Very High Very High
Sleep Disorders 276 99.26 Very High Very High Very High
Emphysema 1 99.20 Very High Very High Very High
Malignant Neoplastic Disease 47 97.12 Very High Very High Very High
Cancer 267 94.84 High High
Diabetes Mellitus 20 93.40 High High
Hyperglycemia 4 88.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, PDGFR-B and IGFBP-3) found to be overexpressed in gastric cancers relative to PN and AN (with the exception of CFD/Adipsin which was overexpressed in PN relative to gastric cancers and AN) were studied for their protein levels in tumour, corresponding PN and in AN tissues.
Gene_expression (overexpressed) of IGFBP-3 associated with cancer and stomach cancer
1) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.55 Pain Relevance 0
These mice over-express human IGFBP-3.
Gene_expression (express) of IGFBP-3
2) Confidence 0.68 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.18 Pain Relevance 0.22
Our goal was to determine, in a murine model, whether matrix metalloproteinase-9 (MMP-9), a known protease of IGFBP-3, is responsible for the postoperative decrease in serum IGFBP-3 levels.
Gene_expression (protease) of IGFBP-3 associated with metalloproteinase
3) Confidence 0.59 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.19 Pain Relevance 0.20
Our goal was to determine, in a murine model, whether matrix metalloproteinase-9 (MMP-9), a known protease of IGFBP-3, is responsible for the postoperative decrease in serum IGFBP-3 levels.
Gene_expression (levels) of IGFBP-3 associated with metalloproteinase
4) Confidence 0.59 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.19 Pain Relevance 0.21
Increased Igfbp3 expression is associated with emphysema [32] and senescent fibroblasts, where it results in Igf1 sequestration and reduced cell proliferation [33,34].
Gene_expression (expression) of Igfbp3 in fibroblasts associated with emphysema
5) Confidence 0.52 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.65 Pain Relevance 0.12
Overexpression of hmutIGFBP3, a mutant form that does not bind IGF, also reduces hypocretin peptide content in brainstem but not in hypothalamus suggesting both IGF dependent and independent effects on hypocretin transmission.
Gene_expression (Overexpression) of hmutIGFBP3 in hypothalamus associated with medulla
6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.64 Pain Relevance 0.05
Of the 8 candidates confirmed by QRT-PCR as downregulated in narcolepsy brains, only one gene, Insulin-like Growth Factor Binding Protein-3 (Igfbp 3), was clearly enriched in the perifornical region where HCRT neurons are located (Table 2, Fig. 1).
Gene_expression (enriched) of Igfbp 3 in neurons associated with sleep disorders
7) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.23 Pain Relevance 0.06
We next measured hypocretin-1 peptide content and hypothalamic preprohypocretin expression (Fig. 3A–C) and found that preprohypocretin mRNA expression was significantly decreased in hIGFBP3 transgenic animals compared to controls, but unaltered in the other models (including hmutIGFBP3 transgenic and Igfbp3 KO mice)(Fig 3A, C).
Gene_expression (transgenic) of hmutIGFBP3 associated with targeted disruption
8) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.47 Pain Relevance 0
Of the 8 candidates confirmed by QRT-PCR as downregulated in narcolepsy brains, only one gene, Insulin-like Growth Factor Binding Protein-3 (Igfbp 3), was clearly enriched in the perifornical region where HCRT neurons are located (Table 2, Fig. 1).
Gene_expression (enriched) of Growth Factor Binding Protein-3 in neurons associated with sleep disorders
9) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.24 Pain Relevance 0.06
To investigate the biological activity of released hGH serum levels of IGF-1 and IGFBP-3, two biomarkers for hGH, were also monitored.


Gene_expression (levels) of IGFBP-3
10) Confidence 0.28 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0.08 Pain Relevance 0
Among IGFBPs, IGFBP-3 is very important since it binds more than 95% of IGF-I in blood circulation.[22]
Gene_expression (important) of IGFBP-3 in blood
11) Confidence 0.18 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.15 Pain Relevance 0.05
GH action positively affects bone growth and bone turnover by stimulating osteoblasts, collagen synthesis and longitudinal bone growth.109 As part from this positive action on bone, GH has a positive action on collagen metabolism, stimulating the expression in osteoblast cultures of IGF-I and IGF binding protein-3, which in turn regulate the synthesis of type I collagen.110,111 Osteoblasts from various species have IGF-I receptors and respond to both endogenous and exogenous IGF by accelerating the proliferation, increasing DNA and collagen synthesis.112,113 On the other hand, animal studies in the mouse model of OI, with bone phenotype comparable to a mild form of OI in humans (oim/+), showed that systemic GH injections114 or GH transgene expression in erythroid marrow115 increased spine and femur length, produced significant changes in densitometric parameters and ameliorated biomechanical structural properties of bone.
Gene_expression (expression) of IGF binding protein-3 in spine associated with osteogenesis imperfecta and osteoporosis
12) Confidence 0.14 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.54 Pain Relevance 0
The post-surgical levels of EpCAM, IGFBP3, IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of IGFBP3
13) Confidence 0.11 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC3004887 Disease Relevance 0.70 Pain Relevance 0
The post-surgical levels of EpCAM, IGFBP3, IL8, CXCL10/IP10, CXCL9/MIG, CCL3/MIP-1?
Gene_expression (/) of IGFBP3
14) Confidence 0.11 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.87 Pain Relevance 0.15
Using IHC, IGFBP3 was found to be overexpressed in gastric cancers relative to the normal gastric tissue [40].
Gene_expression (overexpressed) of IGFBP3 associated with stomach cancer
15) Confidence 0.11 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.17 Pain Relevance 0.10
GH action positively affects bone growth and bone turnover by stimulating osteoblasts, collagen synthesis and longitudinal bone growth.109 As part from this positive action on bone, GH has a positive action on collagen metabolism, stimulating the expression in osteoblast cultures of IGF-I and IGF binding protein-3, which in turn regulate the synthesis of type I collagen.110,111 Osteoblasts from various species have IGF-I receptors and respond to both endogenous and exogenous IGF by accelerating the proliferation, increasing DNA and collagen synthesis.112,113 On the other hand, animal studies in the mouse model of OI, with bone phenotype comparable to a mild form of OI in humans (oim/+), showed that systemic GH injections114 or GH transgene expression in erythroid marrow115 increased spine and femur length, produced significant changes in densitometric parameters and ameliorated biomechanical structural properties of bone.
Gene_expression (expression) of IGF binding protein-3 in femur associated with osteogenesis imperfecta and osteoporosis
16) Confidence 0.05 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.54 Pain Relevance 0
Mean serum levels of IGFBP-3 and the serum IGF-I/IGFBP-2 ratio were also significantly lower in patients than in controls, but values overlapped substantially.
Gene_expression (levels) of IGFBP-3
17) Confidence 0.03 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8550799 Disease Relevance 0 Pain Relevance 0
Patients were compared to normal men by investigating GH sampling every 10 min for 24 h and serum levels of insulin-like growth factor I (IGF-I), IGF-binding protein 2 (IGFBP-2), IGFBP-3, and GH-binding protein.
Gene_expression (levels) of IGFBP-3
18) Confidence 0.03 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8550799 Disease Relevance 0.08 Pain Relevance 0.19

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