INT6107

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Context Info
Confidence 0.81
First Reported 1985
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 180
Total Number 185
Disease Relevance 26.76
Pain Relevance 81.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
neurons 14
hypothalamus 13
nerve 12
nucleus 6
sympathetic 6
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 669 100.00 Very High Very High Very High
noradrenaline 153 100.00 Very High Very High Very High
agonist 136 100.00 Very High Very High Very High
Glutamate 121 100.00 Very High Very High Very High
Enkephalin 104 100.00 Very High Very High Very High
gABA 89 100.00 Very High Very High Very High
substance P 56 100.00 Very High Very High Very High
Serotonin 41 100.00 Very High Very High Very High
medulla 38 100.00 Very High Very High Very High
Calcitonin gene-related peptide 37 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 17 99.96 Very High Very High Very High
Nervous System Injury 67 99.92 Very High Very High Very High
Anaplastic Astrocytoma 3 99.84 Very High Very High Very High
Aids-related Complex 67 99.68 Very High Very High Very High
Diabetes Mellitus 25 99.66 Very High Very High Very High
Neuropathic Pain 42 99.64 Very High Very High Very High
Hypoglycemia 17 99.60 Very High Very High Very High
Pressure Volume 2 Under Development 3 99.56 Very High Very High Very High
Hypertension 27 99.08 Very High Very High Very High
Increased Venous Pressure Under Development 44 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Desipramine suppressed the NPY-LI release induced by tyramine apparently by the inhibition of the uptake of tyramine is suggested by the significant positive correlation between the reduction of 14C-tyramine uptake and the inhibition of NPY-LI release induced by desipramine (r = 0.946).
Localization (release) of NPY associated with desipramine
1) Confidence 0.81 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3108675 Disease Relevance 0 Pain Relevance 0.26
Desipramine suppressed the NPY-LI release induced by tyramine apparently by the inhibition of the uptake of tyramine is suggested by the significant positive correlation between the reduction of 14C-tyramine uptake and the inhibition of NPY-LI release induced by desipramine (r = 0.946).
Localization (release) of NPY associated with desipramine
2) Confidence 0.81 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3108675 Disease Relevance 0 Pain Relevance 0.27
We have used the procedure to show that anaesthesia dramatically decreased NPY release, while a 48 h period of food deprivation significantly increased extracellular NPY concentrations.
Localization (release) of NPY
3) Confidence 0.81 Published 1994 Journal Brain Res. Section Abstract Doc Link 7804826 Disease Relevance 0.24 Pain Relevance 0.08
Fluoxetine also significantly reduced neuropeptide Y levels in the paraventricular nucleus, a major site of neuropeptide Y release which is highly sensitive to the appetite-stimulating actions of neuropeptide Y.
Localization (release) of neuropeptide Y in nucleus associated with neuropeptide and fluoxetine
4) Confidence 0.80 Published 1996 Journal Neuroscience Section Abstract Doc Link 8737424 Disease Relevance 0.46 Pain Relevance 1.03
Injury-related alterations in the regulatory activities of NPY released within the DRG at somally-distributed Y-receptors may also contribute to the development and/or persistence of symptoms characteristic of sympathetically-maintained pain.
Localization (released) of NPY in DRG associated with pain and injury
5) Confidence 0.80 Published 1999 Journal Pain Section Abstract Doc Link 10068164 Disease Relevance 0.54 Pain Relevance 0.30
Whereas, the extent of colocalization of NPY-LI to TH-LI-positive sympathetic axons in unaffected L4 or L5 nerve segments exceeded 80%, this figure declined to approximately 50% in regenerating axons of ligated spinal nerve L5.
Localization (colocalization) of NPY in nerve
6) Confidence 0.80 Published 1999 Journal Pain Section Abstract Doc Link 10068164 Disease Relevance 0.60 Pain Relevance 0.18
It is suggested that NPY is co-released with NE from the postganglionic sympathetic terminals to activate NPY Y(2) and alpha(1) receptors following CAP injection.
Localization (released) of NPY in sympathetic associated with qutenza
7) Confidence 0.79 Published 2004 Journal Neuroscience Section Abstract Doc Link 14698742 Disease Relevance 0 Pain Relevance 1.22
First, we studied the effects of iv saline (controls) or NAL infusion (2 mg/h) between 1100-1400 h on NPY concentrations in seven microdissected sites in the medial basal hypothalamus (MBH) and preoptic area in association with the increase in the rate of LH secretion, and then we examined the effects of NAL on the in vitro release of NPY and LHRH from the MBH of E2-primed ovx rats.
Localization (release) of NPY in hypothalamus associated with narcan
8) Confidence 0.79 Published 1990 Journal Endocrinology Section Abstract Doc Link 2404749 Disease Relevance 0.15 Pain Relevance 0.51
Additionally, NPY is released into the hypophyseal portal blood for transportation to the anterior pituitary where it enhances the release of LH in response to LHRH.
Localization (released) of NPY in anterior pituitary
9) Confidence 0.79 Published 1992 Journal Front Neuroendocrinol Section Abstract Doc Link 1361458 Disease Relevance 0 Pain Relevance 0.10
These observations provided further evidence to support that NPY is released endogenously by TNS at high frequency, acting prejunctionally to suppress sympathetic neurotransmission.
Localization (released) of NPY in sympathetic
10) Confidence 0.79 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 12686755 Disease Relevance 0 Pain Relevance 0.15
The results indicate that NPY is co-released with noradrenaline only during calcium-dependent exocytosis.
Localization (released) of NPY associated with noradrenaline
11) Confidence 0.78 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2615846 Disease Relevance 0.09 Pain Relevance 0.38
To elucidate the potential role of NPY in the endocrine pancreas, we studied the expression and regulation of NPY secretion in a rat insulinoma cell line (INS-1).
Localization (secretion) of NPY in endocrine pancreas associated with hypoglycemia
12) Confidence 0.78 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.10 Pain Relevance 0.08
The glucagon-like peptide-I-(7-36) amide (GLP-1), a known gluco-incretin in humans, induced at low concentration (10(-9) M) a similar expression of NPY mRNA and peptide secretion in INS-1 cells.
Localization (secretion) of NPY
13) Confidence 0.78 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.16 Pain Relevance 0.20
NPY mRNA and peptide are highly expressed and secreted by INS-1 cells.
Localization (secreted) of NPY
14) Confidence 0.78 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.10 Pain Relevance 0.10
AIM: To study the pattern of neuropeptide Y (NPY) Y1 receptor (Y1R) localization in the normal dental pulp and during different stages of pulpal inflammation.
Localization (localization) of neuropeptide Y in dental pulp associated with inflammation and neuropeptide
15) Confidence 0.78 Published 2010 Journal Int Endod J Section Abstract Doc Link 20536577 Disease Relevance 0.17 Pain Relevance 0.26
Therefore, presynaptic alpha2-adrenoceptors modulate the release of NA but not NPY, implying separate regulatory mechanisms.
Localization (release) of NPY associated with noradrenaline
16) Confidence 0.78 Published 2002 Journal Peptides Section Abstract Doc Link 12217427 Disease Relevance 0 Pain Relevance 0.60
In addition, a double-label immunofluorescence method was used to search for co-localization of neuropeptide Y and [Met]enkephalin in spinal cord.
Localization (co-localization) of neuropeptide Y in spinal cord associated with neuropeptide, enkephalin and spinal cord
17) Confidence 0.78 Published 1993 Journal Neuroscience Section Abstract Doc Link 8492914 Disease Relevance 0.09 Pain Relevance 0.96
AIM: To study the pattern of neuropeptide Y (NPY) Y1 receptor (Y1R) localization in the normal dental pulp and during different stages of pulpal inflammation.
Localization (localization) of NPY in dental pulp associated with inflammation and neuropeptide
18) Confidence 0.78 Published 2010 Journal Int Endod J Section Abstract Doc Link 20536577 Disease Relevance 0.17 Pain Relevance 0.26
Scorpion toxin of Androctonus australis garzonii induces neuropeptide Y release via bradykinin stimulation in rat atria and kidneys.
Localization (release) of neuropeptide Y associated with neuropeptide and bradykinin
19) Confidence 0.78 Published 2009 Journal Peptides Section Title Doc Link 19433126 Disease Relevance 0 Pain Relevance 0.52
Taken together, these findings suggest that more NPY release, following low-intensity electrical stimulation of the injured nerve, significantly induces c-Fos expression in the CTNs, which possibly provide the ascending thalamic transmission of neuropathic pain signals.
Localization (release) of NPY in CTNs associated with neuropathic pain and projection neuron
20) Confidence 0.78 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19456245 Disease Relevance 0.51 Pain Relevance 0.62

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