INT6108

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Context Info
Confidence 0.78
First Reported 1984
Last Reported 2010
Negated 9
Speculated 14
Reported most in Abstract
Documents 292
Total Number 306
Disease Relevance 110.65
Pain Relevance 148.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
neurons 44
arcuate nucleus 21
DRG 16
brain 13
nerve 11
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 813 100.00 Very High Very High Very High
Spinal cord 270 100.00 Very High Very High Very High
Calcitonin gene-related peptide 236 100.00 Very High Very High Very High
gABA 207 100.00 Very High Very High Very High
Enkephalin 206 100.00 Very High Very High Very High
substance P 198 100.00 Very High Very High Very High
Somatostatin 152 100.00 Very High Very High Very High
Cholecystokinin 112 100.00 Very High Very High Very High
medulla 68 100.00 Very High Very High Very High
Opioid 63 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1030 100.00 Very High Very High Very High
Aids-related Complex 517 100.00 Very High Very High Very High
Hypersensitivity 49 99.92 Very High Very High Very High
Convulsion 31 99.84 Very High Very High Very High
Anaplastic Astrocytoma 3 99.84 Very High Very High Very High
Obesity 113 99.82 Very High Very High Very High
Headache 10 99.80 Very High Very High Very High
Stress 244 99.76 Very High Very High Very High
Pain 219 99.72 Very High Very High Very High
Injury 358 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased NPY expression was detected in both the Arcuate nucleus (ARN) and the Paraventricular nucleus (PVN) of the Hypothalamus in rats with in STZ-induced diabetes.
Gene_expression (expression) of NPY in Arcuate nucleus associated with diabetes mellitus
1) Confidence 0.78 Published 2004 Journal Acupunct Electrother Res Section Abstract Doc Link 15382790 Disease Relevance 0.35 Pain Relevance 0.37
The present study shows that acupuncture suppressed NPY expression in the ARN and PVN of the Hypothalamus in STZ-induced diabetic rats, suggesting the possibility that acupuncture treatment is effective in curbing the hyperphagia of diabetes.
Gene_expression (expression) of NPY in ARN associated with hyperphagia, diabetes mellitus and acupuncture
2) Confidence 0.78 Published 2004 Journal Acupunct Electrother Res Section Abstract Doc Link 15382790 Disease Relevance 0.64 Pain Relevance 0.36
In the present study, the effect of acupuncture stimulation at Zusanli (St.36) on NPY expression in the Streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry.
Gene_expression (expression) of NPY associated with diabetes mellitus and acupuncture
3) Confidence 0.78 Published 2004 Journal Acupunct Electrother Res Section Abstract Doc Link 15382790 Disease Relevance 0.33 Pain Relevance 0.37
Incubation of the hypothalamic explants with ghrelin significantly increased NPY and AGRP mRNA expression in the presence, but not absence, of dexamethasone.
Gene_expression (expression) of NPY associated with dexamethasone
4) Confidence 0.78 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.28
The stimulatory effects of ghrelin on NPY gene expression were abolished in the presence of cycloheximide, which blocks translation, suggesting that de novo protein synthesis is required for ghrelin action.
Gene_expression (expression) of NPY gene
5) Confidence 0.78 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.32
These data suggest that ghrelin stimulates NPY and AGRP gene expression independently of action potentials only in the presence of glucocorticoids.
Gene_expression (expression) of NPY associated with action potential
6) Confidence 0.78 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.28
Glucocorticoids were also necessary for ghrelin action in vivo because an intracerebroventricular injection of ghrelin significantly increased NPY and AGRP mRNA expression in the arcuate nucleus only in sham-operated, but not in adrenalectomized rats.
Gene_expression (expression) of NPY in arcuate nucleus associated with intracerebroventricular
7) Confidence 0.78 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.30
Because a subpopulation of neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (Arc) projects to the PVN, we measured NPY and POMC mRNA expression in the Arc using in situ hybridization histochemistry at several time points following daily administration of four different antidepressant drugs.
Gene_expression (expression) of NPY in neurons associated with antidepressant, aids-related complex and neuropeptide
8) Confidence 0.77 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.42 Pain Relevance 0.33
In conclusion, our observations suggest that NPY overexpression leads to reduced neuronal activity following nerve injury in a cell-specific manner.
Gene_expression (overexpression) of NPY in neuronal associated with nervous system injury
9) Confidence 0.77 Published 2005 Journal Brain Res. Section Abstract Doc Link 16259969 Disease Relevance 0.88 Pain Relevance 0.34
Furthermore, NPY gene expression is induced within the population of medium- and large-diameter DRG neurons of the A beta-fiber class after experimental nerve injury.
Gene_expression (expression) of NPY gene in nerve associated with nervous system injury
10) Confidence 0.77 Published 1999 Journal Pain Section Abstract Doc Link 10068164 Disease Relevance 0.86 Pain Relevance 0.50
Induction of NPY gene expression in injured DRG neurons is consistent with appearance of NPY-LI-positive end bulbs derived from regenerating sensory axons that are found in developing neuromas containing a relatively high density of transported prejunctional Y2 receptors.
Gene_expression (expression) of NPY gene in neurons associated with neuroma
11) Confidence 0.77 Published 1999 Journal Pain Section Abstract Doc Link 10068164 Disease Relevance 0.43 Pain Relevance 0.24
RT-PCR analyses showed that mRNA expression levels of both NPY and POMC were markedly reduced by fluoxetine treatment in all parts of the brain examined, including the hypothalamus.
Gene_expression (expression) of NPY in hypothalamus associated with fluoxetine
12) Confidence 0.77 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 16042082 Disease Relevance 0.63 Pain Relevance 0.88
Unilateral cuff-induced neuropathy or transection of the rat sciatic nerve did not significantly alter the density or number of DRG neurons expressing NPY receptors.
Gene_expression (expressing) of NPY in DRG associated with induced neuropathy, neuropathic pain and sciatic nerve
13) Confidence 0.77 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8207499 Disease Relevance 0.17 Pain Relevance 0.59
NPY released from these injured large-diameter DRG neurons may act in a paracrine fashion to block the transmission of nociceptive information from the small- and medium-diameter DRG neurons that constitutively express NPY receptors.
Gene_expression (express) of NPY in DRG associated with nociception
14) Confidence 0.77 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8207499 Disease Relevance 0.33 Pain Relevance 0.57
Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury.
Gene_expression (express) of neuropeptide Y in sensory neurons associated with nervous system injury, nociceptor, neuropeptide and peripheral nerve injury
15) Confidence 0.77 Published 1994 Journal J. Neurosci. Section Title Doc Link 8207499 Disease Relevance 0.17 Pain Relevance 0.64
A unimodal size distribution for L4 and L5 DRG neurons expressing NPY binding sites in the rat was determined, with a mean cross-sectional area of 947 microns 2.
Gene_expression (expressing) of NPY in neurons
16) Confidence 0.77 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8207499 Disease Relevance 0.22 Pain Relevance 0.59
Collectively, these results show that a decrease in opioid influence rapidly augments NPY gene expression in a subpopulation of neurons in the ARC, and support the hypothesis that a disinhibition from opioid influence acutely promotes NPY synthesis and release, which is necessary for phasic LH discharge in rats.
Gene_expression (expression) of NPY gene in neurons associated with aids-related complex and opioid
17) Confidence 0.76 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.35 Pain Relevance 0.57
To examine further the relationship between the NAL-induced increase in LH release and increase in NPY gene expression, the effects of NPY mRNA antisense oligonucleotides (oligos) on NPY levels in the ME-ARC and on plasma LH levels were studied in NAL-infused rats.
Gene_expression (expression) of NPY gene in plasma associated with aids-related complex and narcan
18) Confidence 0.76 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.27 Pain Relevance 0.63
To examine further the relationship between the NAL-induced increase in LH release and increase in NPY gene expression, the effects of NPY mRNA antisense oligonucleotides (oligos) on NPY levels in the ME-ARC and on plasma LH levels were studied in NAL-infused rats.
Gene_expression (levels) of NPY in plasma associated with aids-related complex and narcan
19) Confidence 0.76 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.27 Pain Relevance 0.64
In accord with previous studies, NAL infusion significantly increased plasma LH levels at 1400 h. concomitant with this activation of LH release, NPY gene expression was also augmented.
Gene_expression (expression) of NPY gene in plasma associated with narcan
20) Confidence 0.76 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.06 Pain Relevance 0.61

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