INT61087

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Context Info
Confidence 0.35
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 9.10
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 18
lymphocytes 4
head 2
GL7 2
Il2ra (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 144 99.88 Very High Very High Very High
substance P 8 99.80 Very High Very High Very High
antagonist 2 99.06 Very High Very High Very High
Angina 11 98.32 Very High Very High Very High
qutenza 6 98.16 Very High Very High Very High
depression 8 98.08 Very High Very High Very High
tolerance 12 97.32 Very High Very High Very High
Inflammation 118 93.08 High High
tricyclic antidepressant 1 90.08 High High
fluoxetine 1 88.92 High High
Disease Link Frequency Relevance Heat
Frailty 4 99.44 Very High Very High Very High
Nicotine Addiction 91 98.88 Very High Very High Very High
Diabetes Mellitus 48 98.48 Very High Very High Very High
Cv General 3 Under Development 24 98.32 Very High Very High Very High
Bacterial Infection 4 98.32 Very High Very High Very High
Depression 10 98.08 Very High Very High Very High
Pulmonary Disease 87 97.28 Very High Very High Very High
Disease 73 96.60 Very High Very High Very High
Myocardial Infarction 3 96.56 Very High Very High Very High
Brain Injury 21 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, as shown in Fig. 6a, upon in vitro re-stimulation with plate-bound anti-CD3 and soluble anti-CD28, CD4+CD25+ and CD4+CD25?
Positive_regulation (upon) of Gene_expression (shown) of CD25
1) Confidence 0.35 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.38 Pain Relevance 0.09
Strikingly, M2-transduced cells expressed higher levels of CD25 as compared to cells transduced with the control retrovirus, although the MFI of CD25 was similar between the two populations (Figure 3A).
Positive_regulation (levels) of Gene_expression (expressed) of CD25
2) Confidence 0.31 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.16 Pain Relevance 0
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Positive_regulation (mean) of Gene_expression (expression) of CD25 in T cells
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.65 Pain Relevance 0.18
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Positive_regulation (elevated) of Gene_expression (expression) of CD25 in T cells
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.66 Pain Relevance 0.18
M2 protein expression in primary B cells also led to upregulated surface expression of the high affinity IL-2 receptor (CD25) and the activation marker GL7, along with down-regulated surface expression of B220, MHC II, and sIgD.
Positive_regulation ( to upregul) of Gene_expression (ace expres) of IL-2 receptor in GL7
5) Confidence 0.28 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2270344 Disease Relevance 0.43 Pain Relevance 0
As shown in figure 4e, repetitive PTx treatment gradually elevated the frequency of splenic CD4+CD25+FoxP3+ Treg as well as the mean FoxP3 expression of CD4+CD25+ T cells, starting as early as 3 weeks after initiation of PTx treatment.
Positive_regulation (mean) of Gene_expression (expression) of CD25 in T cells
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.32 Pain Relevance 0.18
As shown in figure 4e, repetitive PTx treatment gradually elevated the frequency of splenic CD4+CD25+FoxP3+ Treg as well as the mean FoxP3 expression of CD4+CD25+ T cells, starting as early as 3 weeks after initiation of PTx treatment.
Positive_regulation (elevated) of Gene_expression (expression) of CD25 in T cells
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.33 Pain Relevance 0.19
Without antigen, however, phase two is abbreviated and T cell–DC contacts do not result in the expression of activation markers (CD25), cytokine production (IL-2) or cell division but do induce TCR signaling, which might represent TCR interaction with self-MHC ligands required for optimal foreign antigen reactivity [42].
Neg (not) Positive_regulation (result) of Gene_expression (expression) of CD25 in T cell associated with cytokine
8) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0.09
Moreover, compared to never-smokers, the expansion and activation of airway CD8+ lymphocytes, in terms of increased expression of CD69, HLA-DR and CD25, have been demonstrated in smokers without a clinical diagnosis of COPD (12).
Positive_regulation (increased) of Gene_expression (expression) of CD25 in lymphocytes associated with pulmonary disease and nicotine addiction
9) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.33 Pain Relevance 0.03
Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardial infarction.
Positive_regulation (Increased) of Gene_expression (expression) of CD25 in T cell associated with angina and myocardial infarction
10) Confidence 0.10 Published 2003 Journal Atherosclerosis Section Title Doc Link 12732389 Disease Relevance 0.77 Pain Relevance 0.33
Bexarotene and steroids may increase CD25 expression on T-cells as measured by flow and could suggest synergism (Foss et al 2005).
Spec (may) Positive_regulation (increase) of Gene_expression (expression) of CD25 in T-cells
11) Confidence 0.10 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 1.63 Pain Relevance 0.03
An increase in CD25 and CD54 expression on CD4+ T lymphocytes was related to the bacterial infection (p < 0.05) and accompanied an increase in IL-2 concentration.
Positive_regulation (increase) of Gene_expression (expression) of CD25 in T lymphocytes associated with bacterial infection
12) Confidence 0.07 Published 2002 Journal J Endod Section Abstract Doc Link 12017181 Disease Relevance 0.32 Pain Relevance 0.19
Concomitant administration of SP with the non-peptide Neurokinin-1 receptor (NK1R) antagonist SR140333 completely inhibited the SP-mediated augmentation of Con A-induced PBL proliferation and IL-2 production as well as of CD4+ CD25+ and CD4+ RT1B+ T cell numbers in normal and capsaicin-treated rats.
Positive_regulation (augmentation) of Gene_expression (production) of CD25 in T cell associated with qutenza, antagonist and substance p
13) Confidence 0.06 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378865 Disease Relevance 0 Pain Relevance 0.86
They showed that the standard diet supplemented with arginine reduced thymic atrophy, maintained thymus weight, increased the expression of CD25 and the production of IL-2, and blunted the enterobacterial translocation and dissemination induced by head injury.
Positive_regulation (increased) of Gene_expression (expression) of CD25 in head associated with frailty and brain injury
14) Confidence 0.04 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 1.26 Pain Relevance 0.21
Our data showed (1) an increase in the numbers of lymphocytes bearing lymphocyte activating gene-3 (LAG-3) and CD40 in the blood and (2) an increase in levels of sIL2-R and sVCAM-1 in the sera of patients with unstable angina, compared with normal subjects.
Positive_regulation (increase) of Gene_expression (levels) of sIL2-R in lymphocytes associated with angina
15) Confidence 0.00 Published 1999 Journal Clin. Immunol. Section Abstract Doc Link 10527693 Disease Relevance 0.39 Pain Relevance 0.36
It is suggested that: (1) a coordinated and upregulated production of IL-6, sIL-6R, sIL-2R and TfR may constitute a trait marker of major depression; and that (2) an upregulated production of IL-6 may represent a contributing factor to the various immune disorders encountered in major depression and maybe to the pathophysiology or pathogenesis of that illness.
Positive_regulation (upregulated) of Gene_expression (production) of sIL-2R associated with depression and immune system diseases
16) Confidence 0.00 Published 1995 Journal J Affect Disord Section Abstract Doc Link 8550956 Disease Relevance 0.49 Pain Relevance 0.33

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