INT61096

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.12
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 2
VLPO 2
VLM 2
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 99.70 Very High Very High Very High
Spinal cord 11 99.68 Very High Very High Very High
intrathecal 3 99.48 Very High Very High Very High
monoamine 1 99.02 Very High Very High Very High
Locus ceruleus 1 98.84 Very High Very High Very High
ketamine 4 97.96 Very High Very High Very High
parabrachial 1 94.00 High High
GABAergic 4 93.92 High High
Hippocampus 10 93.20 High High
Dorsal horn 1 89.16 High High
Disease Link Frequency Relevance Heat
Toxocariasis 1 98.72 Very High Very High Very High
Neuropathic Pain 3 98.16 Very High Very High Very High
Sleep Disorders 3 90.56 High High
INFLAMMATION 5 85.60 High High
Temporomandibular Joint Syndrome 6 85.08 High High
Diabetic Nephropathy 3 84.60 Quite High
Pain 2 79.92 Quite High
Stress 56 78.36 Quite High
Hypersensitivity 11 77.24 Quite High
Injury 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to reversing the changes in immune response, intrathecal administration of MK-801 reversed the pattern of c-fos immunoreactivity in the spinal cord after immune challenge in neuropathic animals.
Negative_regulation (reversed) of Regulation (immunoreactivity) of c-fos in spinal cord associated with neuropathic pain, spinal cord and intrathecal
1) Confidence 0.42 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8551356 Disease Relevance 0.60 Pain Relevance 0.59
At higher frequencies c-Fos immunoreactivity decreased in NTS and LRt, disappeared in VLM and increased in NA.
Negative_regulation (decreased) of Regulation (immunoreactivity) of c-Fos in VLM associated with toxocariasis
2) Confidence 0.42 Published 2004 Journal Exp Brain Res Section Abstract Doc Link 15252702 Disease Relevance 0.18 Pain Relevance 0.21
Consistent with its behavioral effects, ketamine induced Fos expression in cholinergic, monoaminergic, and orexinergic arousal systems and completely suppressed Fos immunoreactivity in the sleep-promoting ventrolateral preoptic nucleus (VLPO).
Negative_regulation (suppressed) of Regulation (immunoreactivity) of Fos in VLPO associated with ketamine and monoamine
3) Confidence 0.40 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18383504 Disease Relevance 0.51 Pain Relevance 0.93
In CFA group, these antagonists given locally reduced the Fos-LI response in the laminae I-II at the mid-Vc and Vc/C2 regions.
Negative_regulation (reduced) of Regulation (response) of Fos associated with antagonist and spinal cord
4) Confidence 0.39 Published 2006 Journal Neuroscience Section Abstract Doc Link 16979827 Disease Relevance 0.75 Pain Relevance 0.90
Despite these comparisons, we cannot determine whether the HPA and/or c-fos mRNA responses at D16 are already attenuated with respect to the virgin state and only continue to decline towards D19 (as might be suggested from ACTH responses to combined elevated plus maze and forced swim (Neumann et al. (1998)), or whether the onset of hyporesponsiveness occurs over this time frame.
Spec (whether) Negative_regulation (attenuated) of Spec (whether) Regulation (responses) of fos
5) Confidence 0.21 Published 2010 Journal Brain Research Section Body Doc Link PMC2994639 Disease Relevance 0.08 Pain Relevance 0.12

General Comments

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