INT6110

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Context Info
Confidence 0.56
First Reported 1983
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 83
Total Number 83
Disease Relevance 60.59
Pain Relevance 16.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 34
blood 10
fat 10
liver 4
nerve 4
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 96 100.00 Very High Very High Very High
analgesia 17 99.96 Very High Very High Very High
Sciatic nerve 18 99.66 Very High Very High Very High
cytokine 121 99.52 Very High Very High Very High
Nerve growth factor 36 99.28 Very High Very High Very High
neurotrophin 3 4 99.24 Very High Very High Very High
narcan 10 99.04 Very High Very High Very High
agonist 194 98.96 Very High Very High Very High
diabetic neuropathy 198 98.56 Very High Very High Very High
anesthesia 61 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 523 100.00 Very High Very High Very High
Obesity 439 100.00 Very High Very High Very High
Pressure And Volume Under Development 215 100.00 Very High Very High Very High
Neuropathic Pain 136 100.00 Very High Very High Very High
Diabetes Mellitus 2081 99.92 Very High Very High Very High
Atherosclerosis 58 99.92 Very High Very High Very High
Appetite Loss 402 99.84 Very High Very High Very High
Diabetic Cardiomyopathies 423 99.80 Very High Very High Very High
Metabolic Syndrome 232 99.78 Very High Very High Very High
Hyperglycemia 207 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin and cAMP production by islets of obese rats were both inhibited by the alpha 2-adrenoceptor agonist clonidine.
Negative_regulation (inhibited) of Gene_expression (production) of Insulin associated with obesity, agonist and clonidine
1) Confidence 0.56 Published 1992 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 1322330 Disease Relevance 0.34 Pain Relevance 0.36
In summary, the in vitro and in vivo studies suggest that inhibition of insulin by AR-M100390 is due to a combination of inhibition of insulin synthesis and/or release.
Negative_regulation (inhibition) of Gene_expression (synthesis) of insulin
2) Confidence 0.49 Published 2008 Journal Toxicol. Sci. Section Abstract Doc Link 18539914 Disease Relevance 0.20 Pain Relevance 0.21
The latter regimen also decreased significantly increased plasma levels of insulin and glucose and insulin resistance (HOMA index) at 14 weeks.
Negative_regulation (decreased) of Gene_expression (levels) of insulin in plasma associated with insulin resistance
3) Confidence 0.46 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17988733 Disease Relevance 1.39 Pain Relevance 0.54
The slope of the regression line for glucose disposal rate versus plasma insulin was lower in spontaneously hypertensive rats compared with Wistar-Kyoto rats (2.652 vs. 4.864, P < 0.001), indicating that insulin stimulation of glucose disposal rate was reduced by 50% in spontaneously hypertensive rats.
Negative_regulation (lower) of Gene_expression (slope) of insulin in plasma associated with hypertension
4) Confidence 0.43 Published 1993 Journal Diabetes Section Abstract Doc Link 8349047 Disease Relevance 0.64 Pain Relevance 0.06
Dietary chromium decreases insulin resistance in rats fed a high-fat, mineral-imbalanced diet.
Negative_regulation (decreases) of Gene_expression (resistance) of insulin in fat associated with insulin resistance
5) Confidence 0.43 Published 1998 Journal Metab. Clin. Exp. Section Title Doc Link 9550535 Disease Relevance 0.58 Pain Relevance 0.11
The change in blood glucose following ultrasound mediated insulin delivery was ?
Negative_regulation (was) of Gene_expression (delivery) of insulin in blood
6) Confidence 0.42 Published 2008 Journal International Journal of Nanomedicine Section Abstract Doc Link PMC2626935 Disease Relevance 0 Pain Relevance 0.09
Re-feeding fasted rats reversed HISS-dependent insulin resistance.
Negative_regulation (reversed) of Gene_expression (resistance) of insulin associated with insulin resistance
7) Confidence 0.42 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11911229 Disease Relevance 0.32 Pain Relevance 0.06
Thus, in this model energy (glucose, triglycerides) is not removed from systemic circulation effectively despite elevated insulin (hyperinsulinemia reflecting insulin resistance), which leads to a blood glucose increase that eventually leads to beta-cell failure with decreased insulin production [47,49,50].
Negative_regulation (decreased) of Gene_expression (production) of insulin in blood associated with hyperinsulinism and insulin resistance
8) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2868017 Disease Relevance 0.99 Pain Relevance 0
Infusion of insulin produced a dose-related decrease in MAC that did not differ among groups.
Negative_regulation (decrease) of Gene_expression (produced) of insulin
9) Confidence 0.41 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15155333 Disease Relevance 0 Pain Relevance 0.27
The effect may be due to a capacity of insulin to produce analgesia through an action on one or more neurotransmitter receptors.
Negative_regulation (capacity) of Gene_expression (produce) of insulin associated with neurotransmitter and analgesia
10) Confidence 0.41 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15155333 Disease Relevance 0.09 Pain Relevance 0.55
The reduction of the initial glucose levels versus time after intragastric insulin-loaded SLN, insulin solution and subcutaneous administration of insulin is depicted in Figure 2.
Negative_regulation (reduction) of Gene_expression (solution) of insulin
11) Confidence 0.41 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0.10 Pain Relevance 0.03
The reduction of the initial glucose levels versus time after intragastric insulin-loaded SLN, insulin solution and subcutaneous administration of insulin is depicted in Figure 2.
Negative_regulation (reduction) of Gene_expression (solution) of insulin
12) Confidence 0.41 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0.10 Pain Relevance 0.03
Fasting serum glucose and insulin levels
Negative_regulation (glucose) of Gene_expression (levels) of insulin
13) Confidence 0.41 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788183 Disease Relevance 0.21 Pain Relevance 0
Even though absolute amount of insulin in the diabetic CATO group is not sufficient to cure diabetes, these data suggest that intakes of CATO might improve pancreatic ?
Negative_regulation (absolute) of Gene_expression (amount) of insulin associated with diabetes mellitus
14) Confidence 0.41 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788183 Disease Relevance 0.27 Pain Relevance 0
Eight days of sleep disturbance caused a reduction in body weight together with a decrease in basal levels of glucose and insulin and a decrease in IVGTT levels of insulin.
Negative_regulation (decrease) of Gene_expression (levels) of insulin in body associated with body weight
15) Confidence 0.40 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2842885 Disease Relevance 0.78 Pain Relevance 0.09
mU/g/min insulin infusion rate, insulin levels of about 100??
Negative_regulation (/) of Gene_expression (levels) of insulin
16) Confidence 0.40 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.68 Pain Relevance 0.03
mU/g/min insulin infusion rate, insulin levels of about 100??
Negative_regulation (/) of Gene_expression (levels) of insulin
17) Confidence 0.40 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.68 Pain Relevance 0.03
This leaves the extent of the reduction of insulin resistance between F3.1 (energy restricted post weaning diet) and F3.2 (ad libitum post weaning diet) male and female animals as the only other significant sex-based difference.
Negative_regulation (reduction) of Gene_expression (resistance) of insulin associated with insulin resistance
18) Confidence 0.40 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2575191 Disease Relevance 0.31 Pain Relevance 0
Their common denominator was represented by insulin resistance.
Negative_regulation (represented) of Gene_expression (resistance) of insulin associated with insulin resistance
19) Confidence 0.38 Published 2011 Journal Lipids Health Dis Section Body Doc Link PMC3024237 Disease Relevance 2.25 Pain Relevance 0.07
When cells were treated with agents which inhibit glycolysis (NaF, 2-deoxy-D-glucose) or oxidative metabolism (2,4-dinitrophenol, carbonyl cyanide m-chlorophenyl hydrazone, NaN3, antimycin A), pronounced inhibitions of each of the bioactivities studied (syntheses of glycogen, protein, lipid) were observed, but only the glycolytic inhibitors decreased insulin uptake.
Negative_regulation (decreased) of Gene_expression (uptake) of insulin
20) Confidence 0.38 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3904755 Disease Relevance 0.15 Pain Relevance 0.14

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