INT61100

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Context Info
Confidence 0.51
First Reported 1995
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.53
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Agtr2) transcription factor binding (Agtr2) signal transducer activity (Agtr2)
Anatomy Link Frequency
muscle 1
intestine 1
mast cells 1
Agtr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 100.00 Very High Very High Very High
cINOD 1 100.00 Very High Very High Very High
Calcium channel 1 98.64 Very High Very High Very High
qutenza 1 95.92 Very High Very High Very High
Neuropeptide 1 95.40 Very High Very High Very High
tetrodotoxin 4 90.80 High High
Inflammatory mediators 2 90.08 High High
Root ganglion neuron 1 88.24 High High
b2 receptor 1 86.08 High High
agonist 8 81.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 100.00 Very High Very High Very High
Hypertension 7 98.18 Very High Very High Very High
Pressure And Volume Under Development 7 97.96 Very High Very High Very High
Overdose 1 93.64 High High
Diabetes Mellitus 32 91.40 High High
Hyperkalemia 10 89.20 High High
Ganglion Cysts 1 87.92 High High
Increased Venous Pressure Under Development 1 75.52 Quite High
Renal Failure 2 72.48 Quite High
Insulin Resistance 15 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, local actions in the gut are expected as the AT2 receptor is present in the intestine of the rat and particularly in the mucosa [3,4].
Localization (present) of AT2 in intestine
1) Confidence 0.51 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0.14 Pain Relevance 0.03
Different pathways for Ca2+ mobilization by angiotensin II and carbachol in the circular muscle of the guinea-pig ileum.
Localization (mobilization) of angiotensin II in muscle
2) Confidence 0.19 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10082265 Disease Relevance 0 Pain Relevance 0.25
In rat isolated peritoneal mast cells, DMTI-II failed to directly release histamine.
Neg (failed) Localization (release) of DMTI-II in mast cells
3) Confidence 0.12 Published 2006 Journal Toxicon Section Abstract Doc Link 16386283 Disease Relevance 0.58 Pain Relevance 0.41
This study investigated the anti-hypertensive efficacy and tolerability of once-daily losartan potassium (50 mg titrated to 100 mg), an angiotensin II receptor antagonist, compared with once daily felodipine extended release (ER) (5 mg titrated to 10 mg), a calcium channel blocker, after 12 weeks of therapy in elderly hypertensive patients.
Localization (release) of angiotensin II receptor associated with calcium channel, antagonist and hypertension
4) Confidence 0.11 Published 1995 Journal J Hum Hypertens Section Abstract Doc Link 8551492 Disease Relevance 0.40 Pain Relevance 0.10
Drugs cause impaired renal potassium excretion by (1) interfering with the production and/or secretion of aldosterone (nonsterodial anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, angiotensin-II receptor antagonists, heparin, cyclosporine, and FK 506) or (2) blocking the kaliuretic effects of aldosterone (potassium-sparing diuretics, trimethoprim, pentamidine, and nefamostat mesilate).
Localization (secretion) of angiotensin-II receptor associated with inflammation, antagonist and cinod
5) Confidence 0.09 Published 1998 Journal Am J Ther Section Abstract Doc Link 10099101 Disease Relevance 0.87 Pain Relevance 0.15
Based on its high selectivity for mammalian VGSC subtypes, JZTX-II might be an important ligand for discrimination of VGSC subtypes and for exploration of the distribution and modulation mechanisms of VGSCs.
Localization (selectivity) of JZTX-II
6) Confidence 0.02 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18840410 Disease Relevance 0.09 Pain Relevance 0.20
We assumed that YYJT might promote the secretion of IFG-II to repair or regulate the damaged beta-cells, the exact mechanism however is still unclear and needs further study.


Localization (secretion) of IFG-II
7) Confidence 0.02 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1876602 Disease Relevance 0.46 Pain Relevance 0

General Comments

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