INT61114

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 14.98
Pain Relevance 6.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ppard) lipid binding (Ppard) cell proliferation (Ppard)
nucleus (Ppard) DNA binding (Ppard) lipid metabolic process (Ppard)
Anatomy Link Frequency
colon 2
SW480 1
liver 1
RMIC 1
skeletal muscle 1
Ppard (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 107 99.84 Very High Very High Very High
COX-2 inhibitor 5 99.80 Very High Very High Very High
cOX1 9 98.96 Very High Very High Very High
COX2 34 97.20 Very High Very High Very High
aspirin 21 92.96 High High
agonist 79 76.40 Quite High
Inflammation 125 75.00 Quite High
Analgesic 3 71.12 Quite High
Thalamus 1 70.40 Quite High
Pain 8 62.64 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 113 99.92 Very High Very High Very High
Ovarian Cancer 26 99.86 Very High Very High Very High
Colon Cancer 72 99.62 Very High Very High Very High
Stress 21 98.88 Very High Very High Very High
Cancer 155 98.40 Very High Very High Very High
Polyps 21 98.08 Very High Very High Very High
Lung Cancer 2 98.08 Very High Very High Very High
Death 35 97.08 Very High Very High Very High
Adenoma 15 95.68 Very High Very High Very High
Familial Adenomatous Polyposis 13 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PPARbeta is ubiquitously expressed, and PPARgamma has a restricted pattern of expression, mainly in white and brown adipose tissues, whereas other tissues such as skeletal muscle and heart contain limited amounts.
Gene_expression (expressed) of PPARbeta in heart
1) Confidence 0.75 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0 Pain Relevance 0
The striking distal predilection of nabumetone may be, at least partially, explained by distal bowel over-expression of COX-2 and PPAR-delta.
Gene_expression (over-expression) of PPAR-delta in bowel
2) Confidence 0.73 Published 2001 Journal Int. J. Cancer Section Abstract Doc Link 11304699 Disease Relevance 0.30 Pain Relevance 0.12
To address this question, we evaluated peroxisome proliferator-activated receptor delta (PPARdelta) expression and function in EOC.
Gene_expression (expression) of PPARdelta associated with ovarian cancer
3) Confidence 0.68 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17545608 Disease Relevance 1.10 Pain Relevance 0.32
We found that EOC cells express high levels of PPARdelta, and neutralizing PPARdelta function reduces tumor growth in vivo.
Gene_expression (express) of PPARdelta associated with cancer and ovarian cancer
4) Confidence 0.68 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17545608 Disease Relevance 1.09 Pain Relevance 0.32
To address this question, we evaluated peroxisome proliferator-activated receptor delta (PPARdelta) expression and function in EOC.
Gene_expression (expression) of peroxisome proliferator-activated receptor delta associated with ovarian cancer
5) Confidence 0.68 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17545608 Disease Relevance 1.11 Pain Relevance 0.32
alleles of Ppard had enhanced growth
Gene_expression (alleles) of Ppard
6) Confidence 0.59 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 1.13 Pain Relevance 0.03
Overexpression of PPARdelta by adenoviral transfer rescued 14-3-3epsilon proteins from elimination by sulindac or indomethacin.
Gene_expression (Overexpression) of PPARdelta
7) Confidence 0.58 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409426 Disease Relevance 0.78 Pain Relevance 0.46
Sulindac sulfide inhibited PPARdelta protein expression and PPARdelta transcriptional activity.
Gene_expression (expression) of PPARdelta
8) Confidence 0.58 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409426 Disease Relevance 0.76 Pain Relevance 0.46
Furthermore, the COX-2 inhibitors suppress PPARdelta expression.
Gene_expression (expression) of PPARdelta associated with cox-2 inhibitor
9) Confidence 0.52 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.60 Pain Relevance 0.28
the expression of the liver X-receptor

(LXR), an oxysterol-activated nuclear hormone receptor that increases

Gene_expression (expression) of nuclear hormone receptor in liver
10) Confidence 0.52 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.73 Pain Relevance 0.16
Sulindac sulfide inhibited PPARdelta protein expression and PPARdelta transcriptional activity.
Gene_expression (expression) of PPARdelta
11) Confidence 0.51 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409426 Disease Relevance 0.77 Pain Relevance 0.46
As 14-3-3epsilon promoter activation is mediated by peroxisome proliferator-activated receptor delta (PPARdelta), we determined the correlation between 14-3-3epsilon inhibition and PPARdelta suppression by NSAIDs.
Gene_expression (suppression) of PPARdelta associated with cinod
12) Confidence 0.51 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409426 Disease Relevance 0.75 Pain Relevance 0.46
NSAID-induced 14-3-3epsilon suppression was associated with reduced cytosolic Bad with elevation of mitochondrial Bad and increase in apoptosis which was rescued by Ad-PPARdelta transduction.
Gene_expression (transduction) of PPARdelta associated with cinod and apoptosis
13) Confidence 0.51 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409426 Disease Relevance 0.82 Pain Relevance 0.46
expression in both PPARd?
Gene_expression (expression) of PPARd
14) Confidence 0.51 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.53 Pain Relevance 0.04
There is evidence that they induce colon cancer cell apoptosis by suppressing peroxisome proliferator-activated receptor delta (PPARdelta) through inhibition of COX-2-derived prostacyclin (PGI2).
Gene_expression (suppressing) of PPARdelta in colon associated with colon cancer and apoptosis
15) Confidence 0.45 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.70 Pain Relevance 0.28
Suppression of PPARdelta leads to reduced 14-3-3e and hence a decline in Bad sequestration, resulting in an increased Bad-induced apoptosis via the mitochondrial death pathway.
Gene_expression (Suppression) of PPARdelta associated with apoptosis and death
16) Confidence 0.45 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.78 Pain Relevance 0.27
There is evidence that they induce colon cancer cell apoptosis by suppressing peroxisome proliferator-activated receptor delta (PPARdelta) through inhibition of COX-2-derived prostacyclin (PGI2).
Gene_expression (suppressing) of peroxisome proliferator-activated receptor delta in colon associated with colon cancer and apoptosis
17) Confidence 0.45 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.70 Pain Relevance 0.28
RMICs do not express the prostacyclin receptor, but they do express the prostacyclin responsive nuclear transcription factor peroxisome proliferator-activated receptor delta (PPARdelta).
Gene_expression (express) of PPARdelta
18) Confidence 0.33 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11927585 Disease Relevance 0.59 Pain Relevance 0.51
RMICs do not express the prostacyclin receptor, but they do express the prostacyclin responsive nuclear transcription factor peroxisome proliferator-activated receptor delta (PPARdelta).
Gene_expression (express) of prostacyclin responsive nuclear transcription factor peroxisome proliferator-activated receptor delta
19) Confidence 0.33 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11927585 Disease Relevance 0.58 Pain Relevance 0.51
Overexpression of PPARdelta using an adenovirus not only drove DRE activity but also prevented RMIC death due to COX2 inhibition.
Gene_expression (Overexpression) of PPARdelta in RMIC associated with cox2 and death
20) Confidence 0.33 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11927585 Disease Relevance 0.54 Pain Relevance 0.66

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