INT61118

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 11
Total Number 16
Disease Relevance 4.02
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefl) locomotion (Nefl) response to stress (Nefl)
Anatomy Link Frequency
eyes 1
spinal cord 1
brain 1
frontal cortex 1
Nefl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 6 100.00 Very High Very High Very High
Calcitonin gene-related peptide 2 99.88 Very High Very High Very High
methadone 2 99.56 Very High Very High Very High
cerebral cortex 3 99.24 Very High Very High Very High
induced neuropathy 10 98.72 Very High Very High Very High
opiate 10 97.72 Very High Very High Very High
cocaine 105 97.32 Very High Very High Very High
Spinal cord 45 96.84 Very High Very High Very High
withdrawal 2 96.72 Very High Very High Very High
Sciatic nerve 13 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 11 100.00 Very High Very High Very High
Overdose 4 99.92 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 4 99.40 Very High Very High Very High
Death 2 99.12 Very High Very High Very High
Neuropathic Pain 12 98.72 Very High Very High Very High
Myopia 44 98.56 Very High Very High Very High
Urological Neuroanatomy 2 97.80 Very High Very High Very High
Refractive Errors 34 97.00 Very High Very High Very High
Disease 5 93.56 High High
Poisoning 7 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered gene expression of Adora2b, Arc, CART, Cd47, Drd5, Egr1, Fos, Nefl, NPY, and Nr4a1 were confirmed by qPCR.
Gene_expression (expression) of Nefl associated with aids-related complex
1) Confidence 0.75 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.28 Pain Relevance 0.45
NFL produced higher response rates (45% vs. 26%) and longer remissions (9 months vs. 6 months) than did CMF; overall survival was not different (19 months vs. 16 months).
Gene_expression (produced) of NFL
2) Confidence 0.67 Published 1997 Journal Eur J Cancer Care (Engl) Section Abstract Doc Link 9460336 Disease Relevance 0.26 Pain Relevance 0.14
Levels of NF-L proteins were assessed by immunoblotting techniques.
Gene_expression (Levels) of NF-L
3) Confidence 0.60 Published 1997 Journal Neuroreport Section Abstract Doc Link 9189892 Disease Relevance 0.19 Pain Relevance 0.57
Levels of immunoreactive NF-L proteins were markedly decreased (47%, n = 17) in the frontal cortex.
Gene_expression (Levels) of NF-L in frontal cortex associated with urological neuroanatomy
4) Confidence 0.60 Published 1997 Journal Neuroreport Section Abstract Doc Link 9189892 Disease Relevance 0.20 Pain Relevance 0.59
Ox2r (orexin receptor 2), Calcb (calcitonin gene-related peptide) and Nefl (neurofilament light chain) were not expected a priori to be DE and were chosen for validation to make sure they were not false positives.
Neg (not) Gene_expression (expected) of Nefl associated with calcitonin gene-related peptide
5) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566599 Disease Relevance 0 Pain Relevance 0.13
The contents of six cytoskeletal proteins (NF-L, NF-M, NF-H, alpha-tubulin, beta-tubulin, and beta-actin) in both fractions were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting.
Spec (determined) Gene_expression (contents) of NF-L
6) Confidence 0.41 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17043767 Disease Relevance 0.35 Pain Relevance 0.18
Then, the contents of six cytoskeletal protein (NF-L, NF-M, NF-H, alpha-tubulin, beta-tubulin, and beta-actin) in both fractions were determined by immunoblotting.
Spec (determined) Gene_expression (contents) of NF-L
7) Confidence 0.39 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16474999 Disease Relevance 0.08 Pain Relevance 0.12
Compared with the control, the levels of NF-L, NF-M, NF-H, beta-actin, tau, MAP2 proteins decreased and the level of alpha-tubulin increased in high ACR group, the levels of alpha-tubulin, beta-tubulin and MAP2 increased in low ACR group.
Gene_expression (levels) of NF-L
8) Confidence 0.38 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.07
For that, we investigated the changes of CaM, CaMKII, protein kinase C (PKC) and polymerization ratios (PRs) of NF-L, NF-M and NF-H in cerebral cortex (CC, including total cortex and some gray), spinal cord (SC) and sciatic nerve (SN) of rats treated with HD at a dosage of 1.75 or 3.50 mmol/kg for 8 weeks (five times per week).
Spec (investigated) Gene_expression (changes) of NF-L in spinal cord associated with kinase c, sciatic nerve, cerebral cortex and spinal cord
9) Confidence 0.38 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18582483 Disease Relevance 0.19 Pain Relevance 0.77
The levels of NF-L and NF-H in serum significantly increased, while NF-M, alpha-tubulin, beta-tubulin and beta-actin contents remain unchanged.
Gene_expression (levels) of NF-L
10) Confidence 0.35 Published 2008 Journal Toxicology Section Abstract Doc Link 18177991 Disease Relevance 0.28 Pain Relevance 0.29
The relative levels of six cytoskeletal proteins (NF-L, NF-M, NF-H, alpha-tubulin, beta-tubulin, and beta-actin) in both fractions were determined by immunoblotting.
Spec (determined) Gene_expression (levels) of NF-L
11) Confidence 0.31 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17447142 Disease Relevance 0.16 Pain Relevance 0.11
Early in the development of myopia (within the first 2 days of minus lens wear) and during the greatest increase in axial size and refractive error (see Figure 1), a significantly greater expression of AQP4 was seen in myopic eyes (as a ratio of experimental to fellow eyes) compared to hyperopic eyes in the NFL (t(21)=2.142, p<0.05; Figure 4B and Figure 5A).
Gene_expression (eyes) of NFL in eyes associated with refractive errors and myopia
12) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.58 Pain Relevance 0
The greatest intensity of AQP4 staining was seen in the NFL; however, the greatest intensity of Kir4.1 immunoreactivity was always present in the IPL (see Figure 3 and Figure 4A).


Gene_expression (seen) of NFL
13) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927440 Disease Relevance 0.34 Pain Relevance 0
Furthermore, the levels of mRNA expression of NF-H, NF-M, and NF-L genes were elevated consistently in CS(2)-treated groups.
Gene_expression (expression) of NF-L
14) Confidence 0.23 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17120161 Disease Relevance 0.09 Pain Relevance 0.08
Recently, proteins associated with cell death such as soluble Fas and the brain specific neurofilament triplet protein, glial fibrillary acidic protein and S-100 were found in the CSF of hydrocephalic children reflecting ongoing neurodegeneration [16,17].
Gene_expression (found) of neurofilament triplet protein in brain associated with death
15) Confidence 0.15 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.66 Pain Relevance 0.37
Rat PPAR delta contains a CGG triplet repeat and is prominently expressed in the thalamic nuclei.
Gene_expression (expressed) of triplet
16) Confidence 0.01 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 8554552 Disease Relevance 0.12 Pain Relevance 0.14

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