INT61119

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 9.76
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
muscle 1
brain 1
skeletal muscle 1
beta cells 1
cornea 1


Pain Term Frequency Confidence Heat
Inflammation 14 98.34 Very High Very High Very High
beta blocker 2 92.20 High High
ischemia 3 87.60 High High
fibrosis 18 83.84 Quite High
substance P 10 82.32 Quite High
addiction 1 77.36 Quite High
Chronic pancreatitis 1 75.00 Quite High
diabetic neuropathy 1 74.32 Quite High
ketamine 1 71.60 Quite High
anesthesia 4 69.32 Quite High
Disease Term Frequency Confidence Heat
Insulin Resistance 2 100.00 Very High Very High Very High
Obesity 16 99.50 Very High Very High Very High
Lifespan 131 99.38 Very High Very High Very High
Hyperinsulinism 1 99.36 Very High Very High Very High
Hyperlipidemia 2 99.32 Very High Very High Very High
Diabetes Mellitus 88 99.12 Very High Very High Very High
INFLAMMATION 13 98.34 Very High Very High Very High
Metabolic Syndrome 8 98.12 Very High Very High Very High
Hypertension 33 97.44 Very High Very High Very High
Pressure And Volume Under Development 28 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 48 weeks of treatment, insulin sensitivity was reduced by 23% using atenolol, while it remained unchanged with trandolapril (+0.5%, p = 0.0010) (Reneland et al 2000).
Negative_regulation (reduced) of insulin
1) Confidence 0.57 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663436 Disease Relevance 0.83 Pain Relevance 0.16
Both in vivo and in vitro studies of experimental diabetes report ICC depletion, perhaps secondary to loss of insulin/IGF and/or nitric oxide or other, as yet undetermined, survival factors [7,30-32].
Negative_regulation (loss) of insulin associated with diabetes mellitus
2) Confidence 0.57 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.75 Pain Relevance 0.07
Backcrossing to transgenic mice overexpressing TNF-alpha in their islet beta cells (which also remain normoglycemic, (1)) yielded double transgenics, most of which became diabetic by the age of 4 months; histological analysis revealed a dramatic decrease in insulin-containing beta cells.
Negative_regulation (decrease) of insulin in beta cells associated with targeted disruption and diabetes mellitus
3) Confidence 0.42 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8554587 Disease Relevance 0.58 Pain Relevance 0.11
In brief, the cornea was punctured with a 30 gauge insulin syringe (BD and Co., Franklin Lakes, NJ) and approximately 2 ?
Negative_regulation (punctured) of insulin in cornea
4) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.08 Pain Relevance 0.16
However, ethosuximide and osm-3 mutations extend the lifespan of daf-16 mutants, indicating loss of insulin/IGF-1 signaling cannot fully explain these lifespan extensions [14],[32].
Negative_regulation (loss) of insulin associated with lifespan
5) Confidence 0.41 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2565500 Disease Relevance 0.97 Pain Relevance 0.04
The Leiden 85-plus Study also reported that genetic variation causing a reduction in insulin/IGF-1 signaling resulted in improved old age survival among women [20].
Negative_regulation (reduction) of insulin
6) Confidence 0.41 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995604 Disease Relevance 0.84 Pain Relevance 0
Disorders of growth hormone, insulin and glucocorticoids
Negative_regulation (Disorders) of insulin
7) Confidence 0.41 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC1950217 Disease Relevance 0.91 Pain Relevance 0
In cultured muscle and fat cells, overexpression of Rrad decreases insulin-stimulated glucose uptake [39].
Negative_regulation (decreases) of insulin in fat cells associated with obesity
8) Confidence 0.41 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.58 Pain Relevance 0.03
Seven patients showed insulin resistance and hyperinsulinemia.
Negative_regulation (showed) of insulin associated with hyperinsulinism and insulin resistance
9) Confidence 0.41 Published 2007 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 17873605 Disease Relevance 2.20 Pain Relevance 0.03
Dynamic aerobic exercise, as in walking, enhances a multitude of bodily processes that are inherent in skeletal muscle activity, including the metabolism of high density lipoproteins and insulin/glucose dynamics.
Negative_regulation (metabolism) of insulin in skeletal muscle
10) Confidence 0.41 Published 1997 Journal Sports Med Section Abstract Doc Link 9181668 Disease Relevance 0 Pain Relevance 0
For example, some studies have shown the inflammatory activity, increased action of free radicals, changes of neurotrophic factors, and reduction of insulin transport into the brain in the patients with metabolic syndrome.42,43 It has also been identified as a heterogenous complex that could contribute to both atherothrombotic and lacunar infarctions.44 Various components such as HTN, abnormal TG, and obesity could affect the vascular endothelium and thus cause ischemia.


Negative_regulation (reduction) of insulin in brain associated with inflammation, ischemia, hypertension, metabolic syndrome and brain infarction
11) Confidence 0.41 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2938031 Disease Relevance 1.44 Pain Relevance 0.13
In cultured muscle and fat cells, overexpression of Rrad decreases insulin-stimulated glucose uptake [39].
Negative_regulation (decreases) of insulin in muscle associated with obesity
12) Confidence 0.14 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.58 Pain Relevance 0.03

General Comments

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