INT61120

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 21.15
Pain Relevance 6.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
pancreas 6
T cells 6
dopaminergic neurons 4
ECM 4
macrophage 2
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 31 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
Inflammatory mediators 1 100.00 Very High Very High Very High
Paracetamol 2 99.80 Very High Very High Very High
Inflammation 94 99.64 Very High Very High Very High
fibrosis 80 99.44 Very High Very High Very High
Chronic pancreatitis 29 98.88 Very High Very High Very High
cytokine 150 98.56 Very High Very High Very High
Pain 1 97.64 Very High Very High Very High
imagery 25 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 98 100.00 Very High Very High Very High
Targeted Disruption 53 99.88 Very High Very High Very High
Osteoporosis 5 99.84 Very High Very High Very High
Osteosclerosis 12 99.82 Very High Very High Very High
Pulmonary Fibrosis 47 99.44 Very High Very High Very High
Hypersensitivity 107 99.34 Very High Very High Very High
Apoptosis 238 99.20 Very High Very High Very High
Fibrosis 45 99.12 Very High Very High Very High
Disease 237 98.96 Very High Very High Very High
Pancreatitis 31 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have generated transgenic mice overexpressing TGF-beta 1 in pancreatic beta cells.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TGF-beta 1 in pancreatic beta cells associated with targeted disruption
1) Confidence 0.70 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8554587 Disease Relevance 0.51 Pain Relevance 0.12
TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TGF-beta 1 in pancreas associated with diabetes mellitus and chronic pancreatitis
2) Confidence 0.70 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 8554587 Disease Relevance 0.55 Pain Relevance 0.14
Transforming growth factor beta1 overexpression in the nigrostriatal system increases the dopaminergic deficit of MPTP mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Transforming growth factor beta1 associated with parkinson's disease and enkephalin
3) Confidence 0.70 Published 2003 Journal Mol. Cell. Neurosci. Section Title Doc Link 12932441 Disease Relevance 0.78 Pain Relevance 0.30
Here, we show that overexpression of TGFbeta1, by recombinant adenovirus TGFbeta1 gene transfer, in the mesostriatal system of an MPTP mouse model of PD decreased the number of mesencephalic dopaminergic neurons.
Positive_regulation (transfer) of Gene_expression (transfer) of TGFbeta1 in dopaminergic neurons associated with parkinson's disease and disease
4) Confidence 0.70 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.78 Pain Relevance 0.22
Here, we show that overexpression of TGFbeta1, by recombinant adenovirus TGFbeta1 gene transfer, in the mesostriatal system of an MPTP mouse model of PD decreased the number of mesencephalic dopaminergic neurons.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TGFbeta1 in dopaminergic neurons associated with parkinson's disease and disease
5) Confidence 0.70 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12932441 Disease Relevance 0.79 Pain Relevance 0.21
The pancreas morphology of transgenic mice that overexpress transforming growth factor-beta1 (TGF-beta1) in the pancreas resembles partially morphological features of chronic pancreatitis, such as progressive accumulation of extracellular matrix (ECM).
Positive_regulation (overexpress) of Gene_expression (overexpress) of TGF-beta1 in pancreas associated with targeted disruption and chronic pancreatitis
6) Confidence 0.61 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.59 Pain Relevance 0.18
In comparison with Snus-treated mice, TS-Elastase-IL-1beta mice had an earlier onset and a greater extent of phenotypic changes, which were associated with up-regulation of TNF-alpha and increased expression of IL-6, TGF-beta, and SDF-1.
Positive_regulation (increased) of Gene_expression (expression) of TGF-beta
7) Confidence 0.49 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20065943 Disease Relevance 1.13 Pain Relevance 0.39
No increase in TGF-beta 1 mRNA expression was detected in the spleen following treatment with either agent.
Neg (No) Positive_regulation (increase) of Gene_expression (expression) of TGF-beta 1 in spleen
8) Confidence 0.48 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.10
The pancreas morphology of transgenic mice that overexpress transforming growth factor-beta1 (TGF-beta1) in the pancreas resembles partially morphological features of chronic pancreatitis, such as progressive accumulation of extracellular matrix (ECM).
Positive_regulation (overexpress) of Gene_expression (overexpress) of transforming growth factor-beta1 in pancreas associated with targeted disruption and chronic pancreatitis
9) Confidence 0.44 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.59 Pain Relevance 0.17
Recently, it has been shown that enhanced expression of TGFbeta1 is associated with the progress of pancreatic duct cell carcinoma (PDC) and chronic pancreatitis (CP).
Positive_regulation (enhanced) of Gene_expression (expression) of TGFbeta1 in pancreatic duct associated with pancreatic ductal carcinoma and chronic pancreatitis
10) Confidence 0.41 Published 1998 Journal Pancreas Section Abstract Doc Link 9598806 Disease Relevance 0.95 Pain Relevance 0.50
Acute treatment of B6C3F1 mice with a hepatotoxic dose (500 mg/kg) of carbon tetrachloride (CCl4) produced a marked but transient increase in transforming growth factor beta 1 (TGF-beta 1) mRNA expression in the liver within 24 hr.
Positive_regulation (increase) of Gene_expression (expression) of TGF-beta 1 in liver
11) Confidence 0.39 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.07
In this study we evaluated the use of micro-CT for assessment of pulmonary fibrosis induced by adenoviral gene transfer of biologically active TGF-?
Positive_regulation (transfer) of Gene_expression (transfer) of TGF associated with fibrosis and pulmonary fibrosis
12) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC3022722 Disease Relevance 0.58 Pain Relevance 0.34
A higher production of TGF-?
Positive_regulation (higher) of Gene_expression (production) of TGF
13) Confidence 0.30 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.40 Pain Relevance 0.15
An increased production of TGF-?
Positive_regulation (increased) of Gene_expression (production) of TGF
14) Confidence 0.22 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.50 Pain Relevance 0.13
It has been reported that an increased expression of TGF-?
Positive_regulation (increased) of Gene_expression (expression) of TGF
15) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.66 Pain Relevance 0.13
The results showed that an AC injection of OVA could induce a decreased DTH response in association with an increased production of TGF-?
Positive_regulation (increased) of Gene_expression (production) of TGF associated with hypersensitivity
16) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.74 Pain Relevance 0.03
Overexpression of TGF-?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of TGF
17) Confidence 0.18 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.11 Pain Relevance 0.03
The latter has been ascribed to increased levels of the ECM organizer, transforming growth factor-beta 1 (TGF-?
Positive_regulation (increased) of Gene_expression (levels) of transforming growth factor-beta 1 in ECM
18) Confidence 0.16 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.90 Pain Relevance 0.16
The latter has been ascribed to increased levels of the ECM organizer, transforming growth factor-beta 1 (TGF-?
Positive_regulation (ascribed) of Gene_expression (levels) of transforming growth factor-beta 1 in ECM
19) Confidence 0.16 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.90 Pain Relevance 0.16
Most interestingly, only normal acini suppressed TGFbeta1 expression and accumulation specifically in normal macrophage cultures, while CP acini lost this ability.
Positive_regulation (accumulation) of Gene_expression (expression) of TGFbeta1 in macrophage associated with chronic pancreatitis
20) Confidence 0.14 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18421760 Disease Relevance 1.54 Pain Relevance 1.31

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