INT61134

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Context Info
Confidence 0.46
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.13
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (IL10, IL1B) extracellular space (IL10, IL1B) extracellular region (IL10, IL1B)
aging (IL1B) intracellular (IL10) response to stress (IL10)
Anatomy Link Frequency
blood 2
cartilage 2
CSF 2
IL10 (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Inflammation 4 100.00 Very High Very High Very High
Spinal cord 2 92.32 High High
intrathecal 3 90.40 High High
headache 1 90.28 High High
Osteoarthritis 37 89.80 High High
Pain 10 88.28 High High
allodynia 2 83.60 Quite High
Thermal hyperalgesia 2 82.60 Quite High
Eae 1 71.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 100.00 Very High Very High Very High
Cancer 2 99.60 Very High Very High Very High
Necrosis 3 99.36 Very High Very High Very High
Headache 1 90.28 High High
Chills 1 89.88 High High
Knee Osteoarthritis 36 89.80 High High
Fever 1 89.40 High High
Syndrome 1 88.48 High High
Pain 7 88.28 High High
Injury 3 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dose-related effects of rhIL-10 included transient increases of circulating neutrophils and monocytes and decreases of lymphocytes. rhIL-10 markedly suppressed, in a time- and dose-dependent manner, the synthesis of the inflammatory cytokines IL-1 beta and tumor necrosis factor alpha by whole blood stimulated ex vivo with bacterial lipopolysaccharide.
rhIL-10 Negative_regulation (suppressed) of Gene_expression (synthesis) of IL-1 in blood associated with necrosis, inflammation, cancer and cytokine
1) Confidence 0.46 Published 1996 Journal Blood Section Abstract Doc Link 8555493 Disease Relevance 0.66 Pain Relevance 0.19
In keeping with IL-10's known anti-inflammatory actions, AD-h-IL10 lowered CSF levels of IL-1, relative to control AD.
IL10 Negative_regulation (lowered) of Gene_expression (levels) of IL-1 in CSF associated with inflammation
2) Confidence 0.13 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869510 Disease Relevance 0.97 Pain Relevance 1.22
On one side, IL-10 has proanabolic effects, such as promotion of proteoglycan synthesis by human chondrocytes "in vitro" [17], prevention of cartilage destruction by reducing IL-1 and TNF-alpha mRNA expression in articular chondrocytes [17]; on the other side, IL-10 may also exert procatabolic effects as in human fibroblasts it down-regulates type I collagen mRNA expression and enhances collagenase and stromelysin gene expression [18].
IL-10 Negative_regulation (reducing) of Gene_expression (expression) of IL-1 in cartilage
3) Confidence 0.06 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.51 Pain Relevance 0.23

General Comments

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