INT61136

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 8
Total Number 12
Disease Relevance 2.80
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
brain 2
adipose tissues 1
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 29 100.00 Very High Very High Very High
antagonist 2 98.12 Very High Very High Very High
Central grey 4 92.40 High High
cytokine 3 83.12 Quite High
Central nervous system 2 62.16 Quite High
Enkephalin 1 52.60 Quite High
agonist 1 26.52 Quite Low
Disease Link Frequency Relevance Heat
Skin Cancer 11 99.24 Very High Very High Very High
Obesity 4 98.48 Very High Very High Very High
Urological Neuroanatomy 8 92.40 High High
Lung Cancer 9 91.32 High High
Malignant Neoplastic Disease 3 90.24 High High
Pleural Effusion 1 89.16 High High
Cancer 3 83.60 Quite High
Aggression 15 62.08 Quite High
Injury 1 42.32 Quite Low
Syndrome 29 40.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localisation of melanocortin 1 receptor (MC1R) in WM266-4 human melanoma cells was investigated by applying an antipeptide antiserum specific for the cloned human MC1R (MSH receptor).
Spec (investigated) Localization (localisation) of MC1R associated with melanocortin 1 receptor and skin cancer
1) Confidence 0.75 Published 1996 Journal Cancer Lett. Section Abstract Doc Link 8556703 Disease Relevance 0.17 Pain Relevance 0.42
The localisation of melanocortin 1 receptor (MC1R) in WM266-4 human melanoma cells was investigated by applying an antipeptide antiserum specific for the cloned human MC1R (MSH receptor).
Spec (investigated) Localization (localisation) of melanocortin 1 receptor associated with melanocortin 1 receptor and skin cancer
2) Confidence 0.75 Published 1996 Journal Cancer Lett. Section Abstract Doc Link 8556703 Disease Relevance 0.17 Pain Relevance 0.42
Immunological localisation of melanocortin 1 receptor on the cell surface of WM266-4 human melanoma cells.
Localization (localisation) of melanocortin 1 receptor associated with melanocortin 1 receptor and skin cancer
3) Confidence 0.75 Published 1996 Journal Cancer Lett. Section Title Doc Link 8556703 Disease Relevance 0.19 Pain Relevance 0.46
Expression and localization of melanocortin-1 receptor in human adipose tissues of severely obese patients.
Localization (localization) of melanocortin-1 receptor in adipose tissues associated with melanocortin 1 receptor and obesity
4) Confidence 0.70 Published 2007 Journal Obesity (Silver Spring) Section Title Doc Link 17228030 Disease Relevance 0.19 Pain Relevance 0.10
Using immunofluorescence and ligand binding studies, we found that melanocytic cells exogenously or endogenously expressing MC1R show strong surface localization of the wild-type and D294H alleles but markedly reduced cell surface expression of the R151C and R160W receptors.
Localization (localization) of MC1R
5) Confidence 0.69 Published 2005 Journal Hum. Mol. Genet. Section Abstract Doc Link 15972726 Disease Relevance 0.15 Pain Relevance 0.06
A model is presented of the melanocortin 1 receptor (MC1R), constructed by use of an unbiased, objective method.
Localization (presented) of melanocortin 1 receptor associated with melanocortin 1 receptor
6) Confidence 0.63 Published 1997 Journal J. Mol. Graph. Model. Section Abstract Doc Link 9640562 Disease Relevance 0 Pain Relevance 0.17
A model is presented of the melanocortin 1 receptor (MC1R), constructed by use of an unbiased, objective method.
Localization (presented) of MC1R associated with melanocortin 1 receptor
7) Confidence 0.63 Published 1997 Journal J. Mol. Graph. Model. Section Abstract Doc Link 9640562 Disease Relevance 0 Pain Relevance 0.17
The localization of the melanocortin 1 (MC1) receptor in brain was investigated by in situ hybridization and immunohistochemistry.
Spec (investigated) Localization (localization) of melanocortin 1 in brain
8) Confidence 0.39 Published 1995 Journal Neuroreport Section Abstract Doc Link 8595200 Disease Relevance 0.33 Pain Relevance 0.19
It is remarkable that we found neutral selection on the MC1R gene both in insular and mainland individuals.
Localization (selection) of MC1R gene
9) Confidence 0.37 Published 2010 Journal BMC Evol Biol Section Body Doc Link PMC2949876 Disease Relevance 0.06 Pain Relevance 0
Immunoneutralization of MC1R in the cell lines enhanced expression of interleukin-8 (IL-8), IL-6, and transforming growth factor-beta.
Localization (Immunoneutralization) of MC1R associated with melanocortin 1 receptor
10) Confidence 0.37 Published 2004 Journal J. Leukoc. Biol. Section Abstract Doc Link 14576363 Disease Relevance 1.19 Pain Relevance 0.51
The localization of the melanocortin 1 (MC1) receptor in brain was investigated by in situ hybridization and immunohistochemistry.
Spec (investigated) Localization (localization) of MC1 in brain
11) Confidence 0.34 Published 1995 Journal Neuroreport Section Abstract Doc Link 8595200 Disease Relevance 0.33 Pain Relevance 0.19
Defects in melanocortin ligand biosynthesis, secretion, and melanocortin receptor function can lead to a diverse number of pathological states.
Localization (secretion) of melanocortin receptor
12) Confidence 0.21 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10816638 Disease Relevance 0 Pain Relevance 0.15

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