INT61147

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.76
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
cleavage 2
plaques 1
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Abeta 10 99.88 Very High Very High Very High
Glutamate 68 88.36 High High
Hippocampus 1 73.28 Quite High
imagery 26 69.40 Quite High
cINOD 1 56.48 Quite High
nMDA receptor 8 35.76 Quite Low
tetrodotoxin 1 25.00 Low Low
antagonist 12 12.76 Low Low
agonist 8 11.80 Low Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 24 100.00 Very High Very High Very High
Disease 40 99.30 Very High Very High Very High
Amyloid Plaque 3 97.44 Very High Very High Very High
Drug Induced Neurotoxicity 7 93.92 High High
Neurodegenerative Disease 9 92.04 High High
Apoptosis 98 90.16 High High
Glaucoma 112 88.84 High High
Injury 2 80.16 Quite High
Toxicity 6 73.76 Quite High
Ocular Hypertension 30 72.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endoproteolysis of the amyloid-beta precursor protein (AbetaPP) by the beta-secretase and the gamma-secretase generates Abeta.
Protein_catabolism (Endoproteolysis) of amyloid-beta precursor protein associated with alzheimer's dementia and abeta
1) Confidence 0.60 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20395307 Disease Relevance 0.87 Pain Relevance 0.41
The 4 kDa beta-amyloid (A beta) protein, a major component of cerebral and cerebrovascular plaques in Alzheimer's disease (AD), is derived from the proteolytic cleavage of a larger, membrane-bound precursor, the A beta precursor protein (APP).
Protein_catabolism (cleavage) of APP in plaques associated with alzheimer's dementia and disease
2) Confidence 0.48 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8558231 Disease Relevance 0.47 Pain Relevance 0.04
-Secretase, a membrane-anchored aspartic protease, is responsible for the initial step of APP cleavage in the amyloidogenic pathway leading to the generation of A?
Protein_catabolism (cleavage) of APP in cleavage
3) Confidence 0.42 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.07 Pain Relevance 0.03
is an amino acid peptide derived from the proteolytic cleavage of amyloid precursor protein (APP), a transmembrane protein.
Protein_catabolism (cleavage) of APP in cleavage associated with alzheimer's dementia
4) Confidence 0.31 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.35 Pain Relevance 0.14

General Comments

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