INT6115

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Context Info
Confidence 0.64
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 82
Total Number 85
Disease Relevance 16.96
Pain Relevance 25.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Anatomy Link Frequency
hippocampus 7
striatum 5
gland 4
nucleus accumbens 4
brain 3
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 155 100.00 Very High Very High Very High
Opioid 14 100.00 Very High Very High Very High
aspirin 45 99.76 Very High Very High Very High
Hippocampus 200 99.68 Very High Very High Very High
Nucleus accumbens 14 99.68 Very High Very High Very High
dexamethasone 24 99.54 Very High Very High Very High
ischemia 24 99.50 Very High Very High Very High
Desipramine 5 99.50 Very High Very High Very High
substance P 6 99.44 Very High Very High Very High
Catecholamine 19 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 5 100.00 Very High Very High Very High
Stress 256 99.84 Very High Very High Very High
Coronary Heart Disease 8 99.84 Very High Very High Very High
Diabetes Mellitus 14 99.70 Very High Very High Very High
Multiple Organ Failure 3 99.58 Very High Very High Very High
Convulsion 74 99.56 Very High Very High Very High
Cv Unclassified Under Development 18 99.50 Very High Very High Very High
Eating Disorder 4 99.44 Very High Very High Very High
Shock 24 99.40 Very High Very High Very High
Urological Neuroanatomy 3 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An intragastric (I.G.) infusion of alcohol (2.5 g/kg b.wt) produced a significant increase in PPENK mRNA in the nucleus accumbens (both shell and core) of P but not NP rats at 1 h after the onset of infusion which coincided with the time at which peak BAC was attained.
Positive_regulation (increase) of PPENK mRNA in nucleus accumbens associated with nucleus accumbens and alcohol
1) Confidence 0.64 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630499 Disease Relevance 0.12 Pain Relevance 0.97
Food restriction and diabetes both markedly increased the levels of Prodyn mRNA in the central amygdala (163% and 93%, respectively).
Positive_regulation (increased) of Prodyn mRNA in amygdala associated with diabetes mellitus, amygdala and eating disorder
2) Confidence 0.58 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9191075 Disease Relevance 0.64 Pain Relevance 0.36
EC peptide levels lagged behind the increase in PPenk mRNA and reached a peak of 25 +/- 4 (S.E.M.) pmol Met-enkephalin equivalents/gland at 4 days that was 80 times greater than zero time values.
Positive_regulation (increase) of PPenk mRNA in gland associated with enkephalin
3) Confidence 0.57 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1372065 Disease Relevance 0 Pain Relevance 0.46
After 8 h in culture, total RNA had declined by 60%, epi and norepi declined 80 to 85% and EC peptides by 50% while the amount of PPenk mRNA per gland increased by 400%.
Positive_regulation (increased) of PPenk mRNA in gland
4) Confidence 0.38 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1372065 Disease Relevance 0 Pain Relevance 0.48
Between 8 h and 14 days total RNA and catecholamine levels remained constant while PPenk mRNA increased to a peak of 85 +/- 10 (S.E.M.) pg/gland at 2-4 days, a value that was 80 times greater than the zero time (preculture) values.
Positive_regulation (increased) of PPenk mRNA in gland associated with catecholamine
5) Confidence 0.38 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1372065 Disease Relevance 0 Pain Relevance 0.47
Chronic DMI treatment significantly increased GRII mRNA levels to the same degree in lesioned and non-lesioned animals.
Positive_regulation (increased) of GRII mRNA associated with desipramine
6) Confidence 0.37 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583316 Disease Relevance 0.08 Pain Relevance 0.61
Pretreatment of cells with cycloheximide (a protein synthesis inhibitor; 10 microM) did not affect the forskolin- or PMA-induced increase in proDYN mRNA, but pretreatment with nimodipine (a L-type Ca2+ channel blocker; 2 microM), omega-conotoxin (a N-type Ca2+ channel blocker; 1 microM), or KN-62 (a Ca2+/calmodulin-dependent protein kinase II inhibitor; 5 microM) inhibited induction of proDYN mRNA both by forskolin and PMA.
Positive_regulation (induction) of proDYN mRNA associated with conotoxin
7) Confidence 0.37 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.41
The proDYN mRNA level began to increase 1 h, then reached and remained at a peak 3-6 h after stimulation by forskolin or PMA. proDYN mRNA levels in forskolin treated cells decreased slightly from their peak after 9 h of treatment, whereas the level of proDYN mRNA returned to the basal level in PMA-treated cells.
Positive_regulation (increase) of proDYN mRNA
8) Confidence 0.27 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.29
Calcium influx through both L- and N-type calcium channels and Ca2+/calmodulin-dependent protein kinase II appear to be involved in the increase of proDYN mRNA levels induced by either forskolin or PMA.
Positive_regulation (increase) of proDYN mRNA associated with calcium channel
9) Confidence 0.27 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.26
The proDYN mRNA level began to increase 1 h, then reached and remained at a peak 3-6 h after stimulation by forskolin or PMA. proDYN mRNA levels in forskolin treated cells decreased slightly from their peak after 9 h of treatment, whereas the level of proDYN mRNA returned to the basal level in PMA-treated cells.
Positive_regulation (decreased) of proDYN mRNA
10) Confidence 0.27 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.31
Additionally, dexamethasone did not affect the expression of proDYN mRNA level induced by forskolin.
Positive_regulation (induced) of proDYN mRNA associated with dexamethasone
11) Confidence 0.27 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.41
Calcium influx through both L- and N-type calcium channels and Ca2+/calmodulin-dependent protein kinase II appear to be involved in the increase of proDYN mRNA levels induced by either forskolin or PMA.
Positive_regulation (induced) of proDYN mRNA associated with calcium channel
12) Confidence 0.27 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.26
Pretreatment of cells with cycloheximide (a protein synthesis inhibitor; 10 microM) did not affect the forskolin- or PMA-induced increase in proDYN mRNA, but pretreatment with nimodipine (a L-type Ca2+ channel blocker; 2 microM), omega-conotoxin (a N-type Ca2+ channel blocker; 1 microM), or KN-62 (a Ca2+/calmodulin-dependent protein kinase II inhibitor; 5 microM) inhibited induction of proDYN mRNA both by forskolin and PMA.
Positive_regulation (increase) of proDYN mRNA associated with conotoxin
13) Confidence 0.27 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.39
The proDYN mRNA level began to increase 1 h, then reached and remained at a peak 3-6 h after stimulation by forskolin or PMA. proDYN mRNA levels in forskolin treated cells decreased slightly from their peak after 9 h of treatment, whereas the level of proDYN mRNA returned to the basal level in PMA-treated cells.
Positive_regulation (level) of proDYN mRNA
14) Confidence 0.27 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.30
In the slow kindling model, the level of DYN mRNA in the hippocampus was reduced by 57%, whereas the level of striatal DYN mRNA was increased by 34% compared to sham-operated controls.
Positive_regulation (increased) of DYN mRNA in hippocampus associated with hippocampus
15) Confidence 0.23 Published 1989 Journal Brain Res. Section Abstract Doc Link 2776033 Disease Relevance 0.18 Pain Relevance 0.35
In the striatum, preproenkephalin mRNA abundance linearly increased 8-fold from day 5-43, while a transient increase in the preprocholecystokinin mRNA abundance between days 10 and 20 was noted.
Positive_regulation (increase) of preprocholecystokinin mRNA in striatum
16) Confidence 0.20 Published 1988 Journal Brain Res. Section Abstract Doc Link 3219577 Disease Relevance 0.09 Pain Relevance 0.08
In the presence of cycloheximide, a protein synthesis inhibitor, PEA mRNA was superinduced by a factor of 15-fold.
Positive_regulation (superinduced) of mRNA
17) Confidence 0.19 Published 1991 Journal Endocrinology Section Abstract Doc Link 1855463 Disease Relevance 0 Pain Relevance 0.12
In contrast, elevated DYN mRNA levels were seen in the striatum and hypothalamus.
Positive_regulation (elevated) of DYN mRNA in striatum
18) Confidence 0.16 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2770451 Disease Relevance 0.80 Pain Relevance 0.27
A combination of peripheral acting cholinergic antagonists (chlorisondamine plus methylatropine) prevented the MTZ-induction of adrenal c-fos and PPenk mRNA without significant alterations in the MTZ-induction of hippocampal c-fos mRNA or convulsions.
Positive_regulation (induction) of PPenk mRNA associated with convulsion and antagonist
19) Confidence 0.08 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255173 Disease Relevance 0.18 Pain Relevance 0.33
Trifluoperazine, a calcium/calmodulin inhibitor, attenuated the MTZ-induction of c-fos mRNA while potentiating the MTZ-induction of PPenk mRNA in both the hippocampus and the adrenal.
Positive_regulation (induction) of PPenk mRNA in hippocampus associated with hippocampus
20) Confidence 0.08 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255173 Disease Relevance 0.17 Pain Relevance 0.32

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