INT61158

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 33
Total Number 33
Disease Relevance 11.54
Pain Relevance 18.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
hippocampus 4
brain 3
dorsal horn 3
neurons 3
nucleus accumbens 2
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 78 100.00 Very High Very High Very High
antagonist 34 100.00 Very High Very High Very High
Nucleus accumbens 28 100.00 Very High Very High Very High
Analgesic 13 100.00 Very High Very High Very High
adenocard 5 100.00 Very High Very High Very High
Dorsal horn neuron 4 100.00 Very High Very High Very High
Anterior cingulate cortex 3 100.00 Very High Very High Very High
fluoxetine 81 99.84 Very High Very High Very High
Morphine 177 99.82 Very High Very High Very High
Hippocampus 86 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 47 99.60 Very High Very High Very High
Stress 44 99.22 Very High Very High Very High
Nociception 12 99.08 Very High Very High Very High
Apoptosis 69 98.64 Very High Very High Very High
Toxicity 3 98.44 Very High Very High Very High
Injury 41 97.92 Very High Very High Very High
Neuropathic Pain 30 97.88 Very High Very High Very High
Opiate Addiction 10 95.28 Very High Very High Very High
Ganglion Cysts 28 95.04 Very High Very High Very High
Neurodegenerative Disease 84 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Total CREB and phosphorylated CREB in both ipsilateral and contralateral dorsal horn neurons were dramatically reduced in antisense ODN injected PSNL rats 1 week after injection.
Negative_regulation (reduced) of CREB in neurons associated with dorsal horn neuron
1) Confidence 0.59 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.73 Pain Relevance 0.99
The extent of reduction of total CREB and phosphorylated CREB containing cells in the dorsal horn ipsilateral to injury was greater than in the contralateral dorsal horn.
Negative_regulation (reduction) of CREB in dorsal horn associated with injury and dorsal horn
2) Confidence 0.59 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.70 Pain Relevance 0.96
The extent of reduction of total CREB and phosphorylated CREB containing cells in the dorsal horn ipsilateral to injury was greater than in the contralateral dorsal horn.
Negative_regulation (reduction) of CREB in dorsal horn associated with injury and dorsal horn
3) Confidence 0.59 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.70 Pain Relevance 0.96
It was found that the antisense oligonucleotide-induced reduction in CREB levels mimicked the effect of morphine on certain, but not all, cAMP pathway proteins in this brain region, whereas a large number of other signal transduction proteins tested were unaffected by this treatment.
Negative_regulation (reduction) of CREB in brain associated with morphine
4) Confidence 0.55 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8558448 Disease Relevance 0.17 Pain Relevance 0.92
The functional significance of this CREB down-regulation was then investigated by the use of an anti-sense oligonucleotide strategy that produces a specific and sustained decrease in CREB levels in the NAc, without detectable toxicity.
Negative_regulation (decrease) of CREB in NAc associated with nucleus accumbens and toxicity
5) Confidence 0.55 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8558448 Disease Relevance 0.18 Pain Relevance 0.93
Stressed rats presented a decrease in CAM-L1, laminin, and pCREB, specifically in brain areas implicated in stress.
Negative_regulation (decrease) of pCREB in brain associated with stress
6) Confidence 0.52 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15905095 Disease Relevance 0.49 Pain Relevance 0.35
A significant decrease in both phospho-CREB at Ser133 and phospho-DARPP-32 at Thr34 in the rat caudate putamen was produced by cocaine, GBR 12909, fluoxetine or nisoxetine.
Negative_regulation (decrease) of phospho-CREB in caudate putamen associated with fluoxetine and cocaine
7) Confidence 0.50 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.68
Under these conditions, we found that P-CREB labeling was decreased by 90% (data not shown).
Negative_regulation (decreased) of P-CREB
8) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0.13 Pain Relevance 0.12
Total CREB and phosphorylated CREB in both ipsilateral and contralateral dorsal horn neurons were dramatically reduced in antisense ODN injected PSNL rats 1 week after injection.
Negative_regulation (reduced) of CREB in neurons associated with dorsal horn neuron
9) Confidence 0.43 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.74 Pain Relevance 1.00
A further link between NMDA receptor activation, CREB phosphorylation, and Müller cell proliferation was obtained by cotreatment of the cells with NMDA and the CREB inhibitor for 24 h and coimmunolabeling for BrdU and P-CREB.
Negative_regulation (inhibitor) of CREB associated with nmda receptor
10) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0.18 Pain Relevance 0.08
Our results show that the number of proliferating cells decreases in CREB-inhibitor-treated cells as compared to control cultures (Figure 4A-C).
Negative_regulation (decreases) of CREB
11) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0.14 Pain Relevance 0.11
Knockdown of CREB by small interfering RNA or a dominant-negative form of CREB diminished acid-elevated CGRP expression.
Negative_regulation (Knockdown) of CREB associated with calcitonin gene-related peptide
12) Confidence 0.41 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.13 Pain Relevance 1.39
Treatment of SNL rats with alpha5-antisense significantly reduced pCREB immunoreactivity.
Negative_regulation (reduced) of pCREB associated with spinal nerve ligature
13) Confidence 0.41 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15652389 Disease Relevance 0.57 Pain Relevance 1.24
Intrathecal clonidine decreased pCREB immunoreactive cells in the deep dorsal horn of injured animals.
Negative_regulation (decreased) of pCREB in dorsal horn
14) Confidence 0.36 Published 2003 Journal Anesthesiology Section Body Doc Link 12606922 Disease Relevance 0 Pain Relevance 0
However, calphostin C (a PKC inhibitor) and or SB203580 (a p38 inhibitor) partially but significantly reduced C2 ceramide-induced proENK mRNA expression as well as phospho-CREB level.
Negative_regulation (reduced) of phospho-CREB
15) Confidence 0.31 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0
Antisense-mediated knockdown of CREB (cyclic AMP response-element binding proteins) has however no effect.
Negative_regulation (knockdown) of CREB
16) Confidence 0.31 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373525 Disease Relevance 0.53 Pain Relevance 0.03
As in experiment 1, pCREB was reduced in fluoxetine and K252a-treated animals, but increased expression of Wnt3a still occurred in fluoxetine-treated animals given K252a.
Negative_regulation (reduced) of pCREB associated with fluoxetine
17) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.06 Pain Relevance 0.67
Caspace 1, D2 dopamine receptor, GABA-A alpha1 subunit, GRIA 1/3/4, Galphai2, PSD-95 and CREB were down-regulated in the NAc shell with morphine administration.
Negative_regulation (down-regulated) of CREB in shell associated with nucleus accumbens, gaba, dopamine receptor and morphine
18) Confidence 0.30 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.22
A series of control experiments with various [K+] and stimulus durations revealed that a 45-s delay in control solution provides maximal phosphorylation of CREB; beyond this time, pCREB levels decline, reaching baseline levels within a few minutes.
Negative_regulation (decline) of pCREB
19) Confidence 0.29 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0.17 Pain Relevance 0.11
Indeed, Dowlatshahi et al. [89] reported that CREB levels are decreased in the cerebral cortex of depressed patients.
Negative_regulation (decreased) of CREB in cerebral cortex associated with cerebral cortex
20) Confidence 0.28 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906869 Disease Relevance 0.62 Pain Relevance 0.34

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