INT61158

Context Info Confidence 0.59 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 33 Total Number 33 Disease Relevance 11.54 Pain Relevance 18.06

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1) nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)

Anatomy Link Frequency hippocampus 4 brain 3 dorsal horn 3 neurons 3 nucleus accumbens 2 Creb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate 78 100.00 antagonist 34 100.00 Nucleus accumbens 28 100.00 Analgesic 13 100.00 adenocard 5 100.00 Dorsal horn neuron 4 100.00 Anterior cingulate cortex 3 100.00 fluoxetine 81 99.84 Morphine 177 99.82 Hippocampus 86 99.68

Disease Link Frequency Relevance Heat Depression 47 99.60 Stress 44 99.22 Nociception 12 99.08 Apoptosis 69 98.64 Toxicity 3 98.44 Injury 41 97.92 Neuropathic Pain 30 97.88 Opiate Addiction 10 95.28 Ganglion Cysts 28 95.04 Neurodegenerative Disease 84 94.52

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Anatomy

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Total CREB and phosphorylated CREB in both ipsilateral and contralateral dorsal horn neurons were dramatically reduced in antisense ODN injected PSNL rats 1 week after injection.

Negative_regulation (reduced) of CREB in neurons associated with dorsal horn neuron

1) Confidence 0.59 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.73 Pain Relevance 0.99

The extent of reduction of total CREB and phosphorylated CREB containing cells in the dorsal horn ipsilateral to injury was greater than in the contralateral dorsal horn.

Negative_regulation (reduction) of CREB in dorsal horn associated with injury and dorsal horn

2) Confidence 0.59 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.70 Pain Relevance 0.96

The extent of reduction of total CREB and phosphorylated CREB containing cells in the dorsal horn ipsilateral to injury was greater than in the contralateral dorsal horn.

Negative_regulation (reduction) of CREB in dorsal horn associated with injury and dorsal horn

3) Confidence 0.59 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.70 Pain Relevance 0.96

It was found that the antisense oligonucleotide-induced reduction in CREB levels mimicked the effect of morphine on certain, but not all, cAMP pathway proteins in this brain region, whereas a large number of other signal transduction proteins tested were unaffected by this treatment.

Negative_regulation (reduction) of CREB in brain associated with morphine

4) Confidence 0.55 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8558448 Disease Relevance 0.17 Pain Relevance 0.92

The functional significance of this CREB down-regulation was then investigated by the use of an anti-sense oligonucleotide strategy that produces a specific and sustained decrease in CREB levels in the NAc, without detectable toxicity.

Negative_regulation (decrease) of CREB in NAc associated with nucleus accumbens and toxicity

5) Confidence 0.55 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8558448 Disease Relevance 0.18 Pain Relevance 0.93

Stressed rats presented a decrease in CAM-L1, laminin, and pCREB, specifically in brain areas implicated in stress.

Negative_regulation (decrease) of pCREB in brain associated with stress

6) Confidence 0.52 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15905095 Disease Relevance 0.49 Pain Relevance 0.35

A significant decrease in both phospho-CREB at Ser133 and phospho-DARPP-32 at Thr34 in the rat caudate putamen was produced by cocaine, GBR 12909, fluoxetine or nisoxetine.

Negative_regulation (decrease) of phospho-CREB in caudate putamen associated with fluoxetine and cocaine

7) Confidence 0.50 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.68

Under these conditions, we found that P-CREB labeling was decreased by 90% (data not shown).

Negative_regulation (decreased) of P-CREB

8) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0.13 Pain Relevance 0.12

Total CREB and phosphorylated CREB in both ipsilateral and contralateral dorsal horn neurons were dramatically reduced in antisense ODN injected PSNL rats 1 week after injection.

Negative_regulation (reduced) of CREB in neurons associated with dorsal horn neuron

9) Confidence 0.43 Published 2003 Journal Brain Res. Section Abstract Doc Link 14519530 Disease Relevance 0.74 Pain Relevance 1.00

A further link between NMDA receptor activation, CREB phosphorylation, and Müller cell proliferation was obtained by cotreatment of the cells with NMDA and the CREB inhibitor for 24 h and coimmunolabeling for BrdU and P-CREB.

Negative_regulation (inhibitor) of CREB associated with nmda receptor

10) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0.18 Pain Relevance 0.08

Our results show that the number of proliferating cells decreases in CREB-inhibitor-treated cells as compared to control cultures (Figure 4A-C).

Negative_regulation (decreases) of CREB

11) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0.14 Pain Relevance 0.11

Knockdown of CREB by small interfering RNA or a dominant-negative form of CREB diminished acid-elevated CGRP expression.

Negative_regulation (Knockdown) of CREB associated with calcitonin gene-related peptide

12) Confidence 0.41 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.13 Pain Relevance 1.39

Treatment of SNL rats with alpha5-antisense significantly reduced pCREB immunoreactivity.

Negative_regulation (reduced) of pCREB associated with spinal nerve ligature

13) Confidence 0.41 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15652389 Disease Relevance 0.57 Pain Relevance 1.24

Intrathecal clonidine decreased pCREB immunoreactive cells in the deep dorsal horn of injured animals.

Negative_regulation (decreased) of pCREB in dorsal horn

14) Confidence 0.36 Published 2003 Journal Anesthesiology Section Body Doc Link 12606922 Disease Relevance 0 Pain Relevance 0

However, calphostin C (a PKC inhibitor) and or SB203580 (a p38 inhibitor) partially but significantly reduced C2 ceramide-induced proENK mRNA expression as well as phospho-CREB level.

Negative_regulation (reduced) of phospho-CREB

15) Confidence 0.31 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0

Antisense-mediated knockdown of CREB (cyclic AMP response-element binding proteins) has however no effect.

Negative_regulation (knockdown) of CREB

16) Confidence 0.31 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373525 Disease Relevance 0.53 Pain Relevance 0.03

As in experiment 1, pCREB was reduced in fluoxetine and K252a-treated animals, but increased expression of Wnt3a still occurred in fluoxetine-treated animals given K252a.

Negative_regulation (reduced) of pCREB associated with fluoxetine

17) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.06 Pain Relevance 0.67

Caspace 1, D2 dopamine receptor, GABA-A alpha1 subunit, GRIA 1/3/4, Galphai2, PSD-95 and CREB were down-regulated in the NAc shell with morphine administration.

Negative_regulation (down-regulated) of CREB in shell associated with nucleus accumbens, gaba, dopamine receptor and morphine

18) Confidence 0.30 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.22

A series of control experiments with various [K+] and stimulus durations revealed that a 45-s delay in control solution provides maximal phosphorylation of CREB; beyond this time, pCREB levels decline, reaching baseline levels within a few minutes.

Negative_regulation (decline) of pCREB

19) Confidence 0.29 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0.17 Pain Relevance 0.11

Indeed, Dowlatshahi et al. [89] reported that CREB levels are decreased in the cerebral cortex of depressed patients.

Negative_regulation (decreased) of CREB in cerebral cortex associated with cerebral cortex

20) Confidence 0.28 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906869 Disease Relevance 0.62 Pain Relevance 0.34

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