INT61159

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2010
Negated 4
Speculated 6
Reported most in Body
Documents 46
Total Number 54
Disease Relevance 24.07
Pain Relevance 20.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
cerebral cortex 6
spinal cord 6
hippocampus 5
brain structures 4
cerebellum 4
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 1566 100.00 Very High Very High Very High
Dorsal column 108 100.00 Very High Very High Very High
antagonist 33 100.00 Very High Very High Very High
fluoxetine 221 99.84 Very High Very High Very High
Hippocampus 66 99.84 Very High Very High Very High
Neuropathic pain 12 99.76 Very High Very High Very High
cerebral cortex 260 99.68 Very High Very High Very High
cocaine 5 99.50 Very High Very High Very High
Desipramine 3 99.48 Very High Very High Very High
amygdala 1047 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1859 100.00 Very High Very High Very High
Urological Neuroanatomy 1725 100.00 Very High Very High Very High
Diabetes Mellitus 630 99.84 Very High Very High Very High
Neuropathic Pain 15 99.76 Very High Very High Very High
Nociception 121 99.38 Very High Very High Very High
Cold Sores 378 99.04 Very High Very High Very High
Morphine Dependence 1 97.52 Very High Very High Very High
Drug Dependence 16 97.48 Very High Very High Very High
Anxiety Disorder 525 92.24 High High
INFLAMMATION 18 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the tyrosine hydroxylase (TH), prodynorphin (PDYN), and proenkephalin (PENK) genes contain cAMP response elements that control their expression in their promoters, we used histochemical methods to determine whether ovarian steroids alter expression of the cAMP response element-binding protein (CREB) in the AVPV.
Spec (whether) Regulation (alter) of Gene_expression (expression) of cAMP response element-binding protein in AVPV
1) Confidence 0.62 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8622133 Disease Relevance 0 Pain Relevance 0.21
OBJECTIVE: To investigate the changes of pCREB protein expression in the distal cerebrospinal fluid contacting neurons induced by chronic morphine dependence and withdrawal.
Spec (investigate) Regulation (changes) of Spec (investigate) Gene_expression (expression) of pCREB in cerebrospinal fluid associated with addiction, withdrawal and morphine
2) Confidence 0.61 Published 2009 Journal Neurol. Res. Section Abstract Doc Link 19108758 Disease Relevance 0.10 Pain Relevance 0.31
Changes in the expression and immunoreactivity of CREB and its phosphorylated proteins (CREB-IR and pCREB-IR) in the dorsal horn of the spinal cord were also measured.
Regulation (Changes) of Gene_expression (expression) of CREB in spinal cord
3) Confidence 0.61 Published 2007 Journal Anesth. Analg. Section Body Doc Link 18042889 Disease Relevance 0.25 Pain Relevance 0
injection is likely an underestimate of its value at peak expression of CREB, which occurs at three days after HSV
Regulation (value) of Gene_expression (expression) of CREB associated with cold sores
4) Confidence 0.61 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.42 Pain Relevance 0.06
[Effect of chronic stress on PKA and P-CREB expression in hippocampus of rats and the antagonism of antidepressors].
Regulation (Effect) of Gene_expression (expression) of P-CREB in hippocampus associated with stress and hippocampus
5) Confidence 0.60 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Title Doc Link 17062949 Disease Relevance 0.20 Pain Relevance 0.18
Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.
Regulation (Regulation) of Gene_expression (expression) of CREB in nucleus accumbens associated with nucleus accumbens and morphine
6) Confidence 0.58 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8558448 Disease Relevance 0.14 Pain Relevance 0.85
The curcumin supplementation significantly modulates the altered gene expression of CREB in the cerebral cortex and cerebellum of diabetic rats to near control.
Regulation (modulates) of Gene_expression (expression) of CREB in cerebral cortex associated with diabetes mellitus and cerebral cortex
7) Confidence 0.57 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.53 Pain Relevance 0.41
OBJECTIVE: To investigate whether activation and translocation of extracellular signal-regulated kinase 5 (ERK5) is involved in the induction and maintenance of neuropathic pain and observe the effects of activation and translocation of ERK5 on the expression of phosphorylated cAMP response element binding (pCREB) in the chronic neuropathic pain.
Regulation (effects) of Gene_expression (expression) of pCREB associated with neuropathic pain
8) Confidence 0.57 Published 2009 Journal Neurol. Res. Section Abstract Doc Link 19426589 Disease Relevance 0.27 Pain Relevance 0.31
that long lasting right CeA-PAG pathway potentiation is dependent on pCREB expression [7, 40].
Regulation (dependent) of Gene_expression (expression) of pCREB associated with central grey and amygdala
9) Confidence 0.53 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.42 Pain Relevance 0.84
The up-regulation in pERK and pCREB expressions could be blocked by pretreatment of PD98059.
Regulation (regulation) of Gene_expression (expressions) of pCREB
10) Confidence 0.51 Published 2009 Journal Neurosci Bull Section Body Doc Link 19784086 Disease Relevance 0.07 Pain Relevance 0
The second experiment began by confirming, under our conditions, that a 7-day treatment with fluoxetine had no discernible effect on progenitor mitosis, or pCREB and Wnt3a expression, whereas after 14 days all three were stimulated.
Regulation (effect) of Gene_expression (expression) of pCREB associated with fluoxetine
11) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.33 Pain Relevance 0.57
This paper explores the role of BDNF in this process, using the effect of a Trk antagonist (K252a) on the labelling of progenitor cells with the mitosis marker Ki67 and the associated expression of pCREB and Wnt3a.
Regulation (effect) of Gene_expression (expression) of pCREB associated with antagonist
12) Confidence 0.50 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965105 Disease Relevance 0.08 Pain Relevance 0.64
Because the tyrosine hydroxylase (TH), prodynorphin (PDYN), and proenkephalin (PENK) genes contain cAMP response elements that control their expression in their promoters, we used histochemical methods to determine whether ovarian steroids alter expression of the cAMP response element-binding protein (CREB) in the AVPV.
Spec (whether) Regulation (alter) of Gene_expression (expression) of CREB in AVPV
13) Confidence 0.45 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8622133 Disease Relevance 0 Pain Relevance 0.21
Changes in the expression and immunoreactivity of CREB and its phosphorylated proteins (CREB-IR and pCREB-IR) in the dorsal horn of the spinal cord were also measured.
Regulation (Changes) of Gene_expression (expression) of CREB in spinal cord
14) Confidence 0.45 Published 2007 Journal Anesth. Analg. Section Body Doc Link 18042889 Disease Relevance 0.25 Pain Relevance 0
Moreover, in Handled CREB rats, the increase of pCREB in the right but not left lateral column of the PAG is consistent
Regulation (consistent) of Gene_expression (rats) of CREB in lateral column associated with central grey
15) Confidence 0.45 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.33 Pain Relevance 0.61
controls with the Handled CREB rats falling in between these two groups, differing from neither (Tukey-Kramer
Regulation (controls) of Gene_expression (rats) of CREB
16) Confidence 0.45 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.38 Pain Relevance 0.10
Thus increasing CREB expression directly and genetically in the
Regulation (directly) of Gene_expression (expression) of CREB
17) Confidence 0.45 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.34 Pain Relevance 0.56
also reduced risk assessment, the risk assessment of Handled CREB rats was unaffected and did not differ from
Neg (unaffected) Regulation (unaffected) of Gene_expression (rats) of CREB
18) Confidence 0.45 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.16 Pain Relevance 0.28
robust effects of predator stress and virally induced CREB expression on brain and behavior.
Regulation (effects) of Gene_expression (expression) of CREB in brain associated with stress
19) Confidence 0.45 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.50 Pain Relevance 0.14
column in the Handled CREB group
Regulation (column) of Gene_expression (group) of CREB
20) Confidence 0.45 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.11 Pain Relevance 0.53

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