INT6116

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2010
Negated 1
Speculated 6
Reported most in Abstract
Documents 69
Total Number 75
Disease Relevance 16.43
Pain Relevance 54.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 13
spinal cord 8
spinal 7
hypothalamus 7
amygdala 4
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 642 100.00 Very High Very High Very High
opioid receptor 580 100.00 Very High Very High Very High
Morphine 223 100.00 Very High Very High Very High
Endogenous opioid 130 100.00 Very High Very High Very High
Enkephalin 107 100.00 Very High Very High Very High
agonist 106 100.00 Very High Very High Very High
Analgesic 71 100.00 Very High Very High Very High
Dynorphin 36 100.00 Very High Very High Very High
Nucleus accumbens 35 100.00 Very High Very High Very High
Dopamine 26 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 69 100.00 Very High Very High Very High
Pain 192 99.92 Very High Very High Very High
Nociception 40 99.84 Very High Very High Very High
Cognitive Disorder 33 99.76 Very High Very High Very High
Urological Neuroanatomy 23 99.04 Very High Very High Very High
Shock 7 99.00 Very High Very High Very High
Frailty 44 98.84 Very High Very High Very High
Targeted Disruption 13 98.58 Very High Very High Very High
Depression 8 97.92 Very High Very High Very High
Drug Dependence 11 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, no significant change was observed in the delta-opioid receptor mRNA expression throughout the laminae I-IX at any time points examined.
Neg (no) Regulation (change) of Gene_expression (expression) of delta-opioid receptor mRNA associated with opioid receptor
1) Confidence 0.62 Published 1996 Journal Pain Section Abstract Doc Link 8740615 Disease Relevance 0.15 Pain Relevance 0.50
Animal studies support these findings and demonstrate that chronic cocaine administration can result in alterations in opioid receptor expression and function as measured by changes in critical signal transduction pathways.
Regulation (alterations) of Gene_expression (expression) of opioid receptor associated with opioid receptor and cocaine
2) Confidence 0.58 Published 2001 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11458541 Disease Relevance 0.10 Pain Relevance 0.66
Taken together, these observations suggest that the majority of mu, delta and kappa2 opioid binding sites are localized on non-dopaminergic elements in the caudate-putamen, but that substantia nigra innervation plays a role in the control of striatal opioid receptor expression.
Regulation (control) of Gene_expression (expression) of opioid receptor in substantia nigra associated with substantia nigra, opioid receptor and opioid
3) Confidence 0.53 Published 1993 Journal Neuroscience Section Abstract Doc Link 8232904 Disease Relevance 0 Pain Relevance 0.77
Regulation of opioid receptor expression.
Regulation (Regulation) of Gene_expression (expression) of opioid receptor associated with opioid receptor
4) Confidence 0.50 Published 2002 Journal Curr Opin Pharmacol Section Title Doc Link 11786311 Disease Relevance 0 Pain Relevance 0.33
These results indicate microtubule involvement in regulation of opioid receptor expression.
Regulation (regulation) of Gene_expression (expression) of opioid receptor associated with opioid receptor
5) Confidence 0.47 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3020468 Disease Relevance 0 Pain Relevance 0.37
Alternatively, both opioid receptor and peptide expression in the caudate-putamen may be directly, but independently, regulated by ventral mesencephalic neurons.
Regulation (regulated) of Gene_expression (expression) of opioid receptor in neurons associated with opioid receptor
6) Confidence 0.44 Published 1993 Journal Neuroscience Section Abstract Doc Link 8232904 Disease Relevance 0 Pain Relevance 0.67
A semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was employed to detect changes in the expression of delta- (DOR) kappa- (KOR) and mu- (MOR) opioid receptor mRNAs in rat cochleae at P0, P4, P8 and P16.
Regulation (changes) of Gene_expression (expression) of DOR associated with opioid receptor
7) Confidence 0.44 Published 2003 Journal Hear. Res. Section Abstract Doc Link 14553898 Disease Relevance 0 Pain Relevance 0.25
Northern blot analysis showed that expression of mu-opioid receptor mRNA was intensive in the thalamus, striatum, hypothalamus and pons-medulla, moderate in the hippocampus and midbrain, and slight in the cerebral cortex and cerebellum.
Regulation (intensive) of Gene_expression (expression) of mu-opioid receptor mRNA in hypothalamus associated with medulla, midbrain, hippocampus, thalamus, opioid receptor and cerebral cortex
8) Confidence 0.40 Published 1994 Journal Neurosci. Res. Section Abstract Doc Link 8190373 Disease Relevance 0.06 Pain Relevance 0.82
In addition, our results support the notion that repeated amphetamine-induced changes in opioid receptor expression may contribute to the perpetuation of psychostimulant abuse and/or relapse.
Regulation (changes) of Gene_expression (expression) of opioid receptor associated with opioid receptor and recurrence
9) Confidence 0.39 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12629526 Disease Relevance 0.10 Pain Relevance 0.97
Furthermore, to identify a functional mechanism for cytokine regulation of testicular opioid receptor gene expression, we employed primary Sertoli cells as a model system.
Regulation (regulation) of Gene_expression (expression) of testicular opioid receptor gene in Sertoli cells associated with opioid receptor and cytokine
10) Confidence 0.36 Published 2000 Journal Endocrine Section Abstract Doc Link 11051042 Disease Relevance 0 Pain Relevance 0.69
Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat.
Regulation (effects) of Gene_expression (expression) of opioid receptor gene in brain structures associated with opioid receptor and morphine
11) Confidence 0.33 Published 2006 Journal Neuroscience Section Title Doc Link 16753266 Disease Relevance 0.22 Pain Relevance 0.61
Converging lines of evidence suggest that the pineal hormone, melatonin, may regulate changes in pain threshold by modulating fluctuations in opioid receptor expression and levels of beta-endorphin (beta-END).
Regulation (modulating) of Gene_expression (expression) of opioid receptor associated with pain threshold and opioid receptor
12) Confidence 0.27 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794063 Disease Relevance 0.26 Pain Relevance 0.31
It was hypothesized that the presence or lack thereof of gonadal hormones would alter nociception, an effect temporally correlated with a change in opioid receptor protein expression.
Regulation (change) of Gene_expression (expression) of opioid receptor protein in gonadal associated with nociception and opioid receptor
13) Confidence 0.26 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18054782 Disease Relevance 0.90 Pain Relevance 0.61
These results support previous conclusions that both spinal and supraspinal regulation of endogenous opioid peptide expression plays a role in the response to or onset of post-SCI pain.
Regulation (regulation) of Gene_expression (expression) of opioid peptide in spinal associated with pain, frailty and endogenous opioid
14) Confidence 0.25 Published 2001 Journal Pain Section Abstract Doc Link 11166985 Disease Relevance 0.64 Pain Relevance 0.65
We identified that, in the splenocytes, delta opioid receptor expression is tightly controlled by negative feedback regulation of micro opioid receptors.
Regulation (controlled) of Gene_expression (expression) of opioid receptor associated with opioid receptor
15) Confidence 0.23 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15210757 Disease Relevance 0.08 Pain Relevance 0.75
Taken together, these observations suggest that the majority of mu, delta and kappa2 opioid binding sites are localized on non-dopaminergic elements in the caudate-putamen, but that substantia nigra innervation plays a role in the control of striatal opioid receptor expression.
Regulation (role) of Gene_expression (expression) of opioid receptor in substantia nigra associated with substantia nigra, opioid receptor and opioid
16) Confidence 0.23 Published 1993 Journal Neuroscience Section Abstract Doc Link 8232904 Disease Relevance 0 Pain Relevance 0.77
The cloning of the mu, delta and kappa opioid receptor genes in the early 1990s has allowed the genetic determinants that control the expression of each opioid receptor to be dissected.
Spec (determinants) Regulation (control) of Gene_expression (expression) of opioid receptor associated with kappa opioid receptor and opioid receptor
17) Confidence 0.22 Published 2002 Journal Curr Opin Pharmacol Section Abstract Doc Link 11786311 Disease Relevance 0 Pain Relevance 0.25
Exposure to different drugs of abuse can induce neuroadaptations in the brain and affect opioid gene expression.
Regulation (affect) of Gene_expression (expression) of opioid gene in brain associated with opioid
18) Confidence 0.21 Published 2006 Journal Neuroscience Section Abstract Doc Link 16289352 Disease Relevance 0.09 Pain Relevance 0.29
Regional changes in opioid receptor gene expression levels might reflect highly specialized roles for these receptors with possible functional meaning for the plasticity of the opioidergic transmission.
Regulation (changes) of Gene_expression (expression) of opioid receptor gene associated with opioid receptor
19) Confidence 0.20 Published 2006 Journal Neuroscience Section Abstract Doc Link 16753266 Disease Relevance 0.26 Pain Relevance 0.59
Several reports provided possible mechanisms to explain the prenatally morphine-induced tolerance to morphine, including changes in opioid receptor density [17,27,28], intracellular cAMP levels [29], G protein mRNA levels [30], and expression of endogenous opioids [31].
Regulation (changes) of Gene_expression (expression) of opioid receptor associated with endogenous opioid, tolerance, opioid receptor and morphine
20) Confidence 0.20 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890660 Disease Relevance 0.19 Pain Relevance 1.55

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