INT61160

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 37
Total Number 42
Disease Relevance 17.95
Pain Relevance 23.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
spinal cords 6
hippocampus 4
spinal 4
lateral 4
brainstem 4
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 208 100.00 Very High Very High Very High
cerebral cortex 79 100.00 Very High Very High Very High
Dorsal column 72 100.00 Very High Very High Very High
withdrawal 55 100.00 Very High Very High Very High
Morphine 41 100.00 Very High Very High Very High
Spinal cord 34 100.00 Very High Very High Very High
antagonist 22 100.00 Very High Very High Very High
Central nervous system 17 100.00 Very High Very High Very High
Analgesic 12 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1235 100.00 Very High Very High Very High
Neuroleptic Malignant Syndrome 4 100.00 Very High Very High Very High
Depression 66 99.60 Very High Very High Very High
Urological Neuroanatomy 1144 99.52 Very High Very High Very High
Diabetes Mellitus 180 99.36 Very High Very High Very High
Nociception 27 99.08 Very High Very High Very High
Overdose 2 98.76 Very High Very High Very High
Toxicity 1 98.72 Very High Very High Very High
Cold Sores 252 98.64 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 3 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracerebroventricular infusions of antisense CREB oligodeoxynucleotides significantly reduced the 24-hour carotid-artery ligation-induced neuroprotection effects by decreasing CREB expressions.
Negative_regulation (decreasing) of Gene_expression (expressions) of CREB in artery associated with intracerebroventricular
1) Confidence 0.59 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15470752 Disease Relevance 0.63 Pain Relevance 0.13
In contrast, PKC inhibitor calphostin C reduced the withdrawal-triggered rise in pCREB, pERK(1/2), TH expression and corticosterone secretion.
Negative_regulation (reduced) of Gene_expression (expression) of pCREB associated with kinase c and withdrawal
2) Confidence 0.50 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.16 Pain Relevance 1.14
K252a also blocked the fluoxetine-induced expression of pCREB, supporting the role for this compound in the control of neurogenesis.
Negative_regulation (blocked) of Gene_expression (expression) of pCREB associated with neurodegenerative disease and fluoxetine
3) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.40 Pain Relevance 0.43
Attenuated expression of withdrawal behaviors correlated with decreased c-Fos expression and intracellular signal transduction elements [protein kinase A regulatory subunit II (PKA) and phosphorylated cAMP response element binding protein (pCREB)] in brainstem noradrenergic nuclei.
Negative_regulation (decreased) of Gene_expression (expression) of pCREB in brainstem associated with medulla and withdrawal
4) Confidence 0.45 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16385558 Disease Relevance 0.08 Pain Relevance 0.58
Both formalin-evoked CREB phosphorylation and c-Fos expression in the spinal cord were suppressed by pretreatment with the NMDA receptor antagonist MK-801 (3.5 mg/kg, i.p.) or halothane anesthesia.
Negative_regulation (suppressed) of Gene_expression (expression) of CREB in spinal cord associated with anesthesia, nmda receptor antagonist, halothane and spinal cord
5) Confidence 0.43 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9030636 Disease Relevance 0.56 Pain Relevance 0.81
At the cellular level, CREBGFP expression in the LC in vivo and in vitro had no significant effect on neuronal firing at baseline but enhanced the excitatory effect of forskolin (an activator of adenylyl cyclase) on these neurons, which suggests that the cAMP signaling pathway in these neurons was sensitized after CREB expression.
Negative_regulation (sensitized) of Gene_expression (expression) of CREB in neurons associated with locus ceruleus
6) Confidence 0.43 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16641242 Disease Relevance 0 Pain Relevance 0.96
predator stressed and Handled CREB rats exhibited more pCREB lir in the right over the left (all t, P < .04,
Negative_regulation (exhibited) of Gene_expression (rats) of CREB
7) Confidence 0.42 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.38 Pain Relevance 0.11
likely an underestimate of its value at peak expression of CREB, which occurs at three days after HSV
Negative_regulation (at) of Gene_expression (expression) of CREB associated with cold sores
8) Confidence 0.42 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.01 Pain Relevance 0.24
Further studies examining CREB and pCREB expression in lateral PAG at 1–3 days post HSV injection are required to
Spec (examining) Negative_regulation (examining) of Gene_expression (expression) of CREB in lateral associated with cold sores and central grey
9) Confidence 0.42 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.07 Pain Relevance 0.30
This

especially concerns the absence of reduced risk assessment in the Handled CREB group, since NMDA block in the left

Negative_regulation (reduced) of Gene_expression (group) of CREB
10) Confidence 0.42 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.32 Pain Relevance 0.57
Knockdown of CREB by small interfering RNA or a dominant-negative form of CREB diminished acid-elevated CGRP expression.
Negative_regulation (Knockdown) of Gene_expression (expression) of CREB associated with calcitonin gene-related peptide
11) Confidence 0.41 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.13 Pain Relevance 1.42
The functional significance of this CREB down-regulation was then investigated by the use of an anti-sense oligonucleotide strategy that produces a specific and sustained decrease in CREB levels in the NAc, without detectable toxicity.
Negative_regulation (decrease) of Gene_expression (levels) of CREB in NAc associated with nucleus accumbens and toxicity
12) Confidence 0.41 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8558448 Disease Relevance 0.18 Pain Relevance 0.94
Real Time-PCR analysis showed that the CREB gene expression in the cerebral cortex and cerebellum was significantly decreased (p < 0.001) in diabetic condition.
Negative_regulation (decreased) of Gene_expression (expression) of CREB gene in cerebellum associated with diabetes mellitus and cerebral cortex
13) Confidence 0.40 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.52 Pain Relevance 0.59
In addition, the antisense knockdown of ERK5 reduced CFA-induced phosphorylation of cAMP response-element binding protein (CREB), a downstream substrate of the ERK5 pathway, and expression of Fos, a marker for neuronal activation in the central nervous system.
Negative_regulation (reduced) of Gene_expression (expression) of CREB in neuronal associated with central nervous system
14) Confidence 0.38 Published 2008 Journal Brain Res. Section Abstract Doc Link 18486117 Disease Relevance 0.51 Pain Relevance 0.77
In addition, the antisense knockdown of ERK5 reduced CFA-induced phosphorylation of cAMP response-element binding protein (CREB), a downstream substrate of the ERK5 pathway, and expression of Fos, a marker for neuronal activation in the central nervous system.
Negative_regulation (reduced) of Gene_expression (expression) of cAMP response-element binding protein in neuronal associated with central nervous system
15) Confidence 0.38 Published 2008 Journal Brain Res. Section Abstract Doc Link 18486117 Disease Relevance 0.51 Pain Relevance 0.77
If decreases of pCREB expression in
Negative_regulation (decreases) of Gene_expression (expression) of pCREB
16) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.51 Pain Relevance 0.19
The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex.
Negative_regulation (decreased) of Gene_expression (levels) of P-CREB in cortex associated with stress, depression and hippocampus
17) Confidence 0.37 Published 2008 Journal Neurobiol. Dis. Section Abstract Doc Link 18586506 Disease Relevance 0.62 Pain Relevance 0.71
predator stress on pCREB expression are evident at 20 minutes post stress and fade
Negative_regulation (stress) of Gene_expression (expression) of pCREB associated with stress
18) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.02 Pain Relevance 0.23
In the present study pCREB expression in predator stressed rats
Negative_regulation (stressed) of Gene_expression (expression) of pCREB
19) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.37 Pain Relevance 0.15
The

reduced power for the lateral column pCREB findings suggests a fading effect in

Negative_regulation (reduced) of Spec (findings) Gene_expression (findings) of pCREB in lateral column
20) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.49 Pain Relevance 0.14

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