INT61171

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1995
Last Reported 2010
Negated 9
Speculated 6
Reported most in Abstract
Documents 92
Total Number 98
Disease Relevance 57.74
Pain Relevance 9.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100A8) extracellular region (S100A8) plasma membrane (S100A8)
cytoskeleton (S100A8) cytoplasm (S100A8)
Anatomy Link Frequency
macrophages 6
neutrophils 6
MIA PaCa-2 2
PANC-1 2
plaque 2
S100A8 (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 26 100.00 Very High Very High Very High
fibrosis 21 100.00 Very High Very High Very High
peptic ulcer disease 80 99.92 Very High Very High Very High
Acupuncture 52 99.86 Very High Very High Very High
Inflammation 77 98.92 Very High Very High Very High
Angina 28 98.60 Very High Very High Very High
Chronic pancreatitis 29 97.96 Very High Very High Very High
Inflammatory response 10 97.52 Very High Very High Very High
abdominal pain 9 97.20 Very High Very High Very High
cINOD 13 94.92 High High
Disease Link Frequency Relevance Heat
Ulcers 154 100.00 Very High Very High Very High
Duodenal Ulcer 20 100.00 Very High Very High Very High
Cystic Fibrosis 19 100.00 Very High Very High Very High
Atherosclerotic Plaque 17 100.00 Very High Very High Very High
Gastroesophageal Reflux Disease 6 100.00 Very High Very High Very High
Sprains And Strains 177 99.98 Very High Very High Very High
Gastritis 152 99.98 Very High Very High Very High
Pancreatic Cancer 80 99.96 Very High Very High Very High
Disease 306 99.92 Very High Very High Very High
Cancer 120 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated p8 expression in 72 human pancreatic tissues, including 38 pancreatic cancers (PCs), by immunohistochemistry. p8 was overexpressed (positive cells >25% in 1,000 cells) in 71% (27 of 38) of PCs, but in only 17% (3 of 18) of chronic pancreatitis cases.
Spec (investigated) Gene_expression (expression) of p8 associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.76 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11234885 Disease Relevance 0.90 Pain Relevance 0.09
However, the expression of p8 in pancreatic cancer is not reported.
Gene_expression (expression) of p8 associated with pancreatic cancer
2) Confidence 0.76 Published 2001 Journal Clin. Cancer Res. Section Abstract Doc Link 11234885 Disease Relevance 0.79 Pain Relevance 0.08
No correlation was found between the gastric site colonized by H. pylori or strains expressing CagA and the prevention or development of erosive esophagitis in patients with peptic ulcer disease, 1 year after infection eradication.


Gene_expression (expressing) of CagA
3) Confidence 0.75 Published 2009 Journal Arq Gastroenterol Section Body Doc Link 19918687 Disease Relevance 0.05 Pain Relevance 0
Strains producing the CagA antigen (cagA(+)) induce strong gastric inflammation and are strongly associated with gastric adenocarcinoma and MALT lymphoma.
Gene_expression (producing) of CagA in MALT associated with adenocarcinoma, lymphatic system cancer, inflammation and sprains and strains
4) Confidence 0.75 Published 2000 Journal Science Section Abstract Doc Link 10688800 Disease Relevance 0.95 Pain Relevance 0.15
The presence of serum IgG antibodies to HP and to CagA and plasma interleukin-8 (IL-8) levels was measured by ELISA.
Gene_expression (levels) of CagA in plasma associated with gastritis
5) Confidence 0.75 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10695556 Disease Relevance 2.31 Pain Relevance 0.13
The aim of this study was to determine the seroprevalence of HP infection and antibodies to CagA, an antigen that is expressed by the most virulent HP strains inducing an enhanced gastric inflammatory response, in patients undergoing routine coronary artery examination.
Gene_expression (expressed) of CagA in coronary artery associated with inflammatory response, sprains and strains, gastritis and infection
6) Confidence 0.75 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10695556 Disease Relevance 2.23 Pain Relevance 0.17
Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina.
Gene_expression (expression) of S100A8 in neutrophils associated with atherosclerotic plaque and angina
7) Confidence 0.75 Published 2008 Journal Heart Section Title Doc Link 18308864 Disease Relevance 0.20 Pain Relevance 0.14
The cagA was detected in 76% of H. pylori-positive cases.
Gene_expression (detected) of cagA
8) Confidence 0.75 Published 2008 Journal Jpn. J. Infect. Dis. Section Abstract Doc Link 18653971 Disease Relevance 1.84 Pain Relevance 0.58
The presence of the cagA gene was closely associated with the vacA genotype s1 and found in 124 (88.6%) and in 113 (80.7%) of patients with the s1m1 or s1m2 genotypes, respectively, whereas strains with the genotype s2m2 were almost exclusively cagA negative.
Neg (negative) Gene_expression (negative) of cagA
9) Confidence 0.75 Published 2000 Journal Z Gastroenterol Section Body Doc Link 10965552 Disease Relevance 0.06 Pain Relevance 0
The cagA gene was detected in 73.4% of the strains.
Gene_expression (detected) of cagA associated with sprains and strains
10) Confidence 0.75 Published 2006 Journal Acta Trop. Section Abstract Doc Link 17181989 Disease Relevance 1.15 Pain Relevance 0.07
In patients with UA, immunodouble staining clearly showed that the S100A8/A9 complex was expressed in infiltrated neutrophils and occasional macrophages.
Gene_expression (expressed) of S100A8 in macrophages
11) Confidence 0.75 Published 2008 Journal Heart Section Body Doc Link 18308864 Disease Relevance 0.13 Pain Relevance 0
BACKGROUND: The S100A8/A9 complex is expressed in a subset of activated neutrophils and macrophages in acute inflammatory lesions associated with various diseases.
Gene_expression (expressed) of S100A8 in macrophages associated with inflammation and disease
12) Confidence 0.75 Published 2008 Journal Heart Section Abstract Doc Link 18308864 Disease Relevance 0.34 Pain Relevance 0.12
OBJECTIVE: To investigate (a) whether serum S100A8/A9 levels are increased in patients with unstable angina (UA); and (b) whether S100A8/A9 expression is upregulated in coronary atherosclerotic plaques of patients with UA.
Spec (whether) Gene_expression (expression) of S100A8 in plaques
13) Confidence 0.75 Published 2008 Journal Heart Section Body Doc Link 18308864 Disease Relevance 0.19 Pain Relevance 0
The most virulent strains, such as those expressing the cytotoxin-associated gene A (CagA), and the site of gastric colonization have been correlated with the prevention or development of esophagitis.
Gene_expression (expressing) of CagA associated with esophageal disease and sprains and strains
14) Confidence 0.75 Published 2009 Journal Arq Gastroenterol Section Abstract Doc Link 19918687 Disease Relevance 0.78 Pain Relevance 0.07
Enhanced expression of the S100A8/A9 complex in acute myocardial infarction patients.
Gene_expression (expression) of S100A8 associated with myocardial infarction
15) Confidence 0.75 Published 2010 Journal Circ. J. Section Title Doc Link 20190427 Disease Relevance 0.37 Pain Relevance 0.18
The cagA gene was detected in 81% of HP-positive samples.
Gene_expression (detected) of cagA
16) Confidence 0.75 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12141819 Disease Relevance 1.15 Pain Relevance 0.15
G542X is a Class I mutation that results in the complete failure to synthesize functional cystic fibrosis transmembrane conductance regulator (CFTR) and is usually associated with pancreatic insufficiency.
Neg (failure) Gene_expression (synthesize) of cystic fibrosis associated with fibrosis, exocrine pancreatic insufficiency and cystic fibrosis
17) Confidence 0.75 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936924 Disease Relevance 1.38 Pain Relevance 0.34
The cagA gene was detected in 35 (67.3%) out of these 52 specimens (ureA+).
Gene_expression (detected) of cagA
18) Confidence 0.75 Published 2004 Journal Wiad. Lek. Section Abstract Doc Link 15865238 Disease Relevance 0.78 Pain Relevance 0.09
Presence of CagA protein depends on possession by a strain of cagA gene.
Gene_expression (Presence) of CagA associated with sprains and strains
19) Confidence 0.75 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9376616 Disease Relevance 0.94 Pain Relevance 0.15
BACKGROUND: The expression of two Helicobacter pylori proteins, CagA and VacA, is associated with more severe pathogenesis and clinical outcomes of the infection.
Gene_expression (expression) of CagA associated with ulcers and infection
20) Confidence 0.75 Published 2004 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 15074390 Disease Relevance 0.42 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox