INT61172

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Context Info
Confidence 0.77
First Reported 1995
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 34
Total Number 37
Disease Relevance 8.89
Pain Relevance 15.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
SH-SY5Y 5
tail 3
MCF-7 1
nucleus 1
neuronal 1
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 519 100.00 Very High Very High Very High
Opioid 45 99.98 Very High Very High Very High
Hyperalgesia 5 99.54 Very High Very High Very High
qutenza 8 99.12 Very High Very High Very High
peptic ulcer disease 1 99.08 Very High Very High Very High
agonist 555 98.84 Very High Very High Very High
opioid receptor 20 98.68 Very High Very High Very High
Dopamine 18 97.60 Very High Very High Very High
adenocard 75 96.76 Very High Very High Very High
GABAergic 15 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Glioma 6 99.96 Very High Very High Very High
Apoptosis 245 99.92 Very High Very High Very High
Sprains And Strains 30 99.64 Very High Very High Very High
Hyperalgesia 7 99.54 Very High Very High Very High
Ulcers 4 99.48 Very High Very High Very High
Virus Diseases 267 99.32 Very High Very High Very High
Neuroblastoma 10 98.96 Very High Very High Very High
Targeted Disruption 22 98.64 Very High Very High Very High
Disease 79 98.56 Very High Very High Very High
Hyperglycemia 38 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to expressing conventional (PKC-alpha) and novel (PKC-epsilon) isoforms, SH-SY5Y cells also contain a DAG- and Ca2+-independent, atypical PKC isozyme (PKC-zeta), which does not decrease in expression after prolonged DAMGO or phorbol ester treatment.
Gene_expression (expressing) of PKC-alpha in SH-SY5Y associated with kinase c
1) Confidence 0.77 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.06 Pain Relevance 1.68
In this series of experiments, we continue our investigation of how opioid-activated PKC contributes to homologous receptor down-regulation and then expand our focus to include the exploration of the mechanism(s) by which mu-opioids produce PKC translocation in SH-SY5Y neuroblastoma cells.
Gene_expression (produce) of PKC in SH-SY5Y associated with neuroblastoma, kinase c and opioid
2) Confidence 0.60 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.10 Pain Relevance 1.34
In addition to expressing conventional (PKC-alpha) and novel (PKC-epsilon) isoforms, SH-SY5Y cells also contain a DAG- and Ca2+-independent, atypical PKC isozyme (PKC-zeta), which does not decrease in expression after prolonged DAMGO or phorbol ester treatment.
Gene_expression (expressing) of PKC in SH-SY5Y associated with kinase c
3) Confidence 0.58 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.06 Pain Relevance 1.75
In addition to expressing conventional (PKC-alpha) and novel (PKC-epsilon) isoforms, SH-SY5Y cells also contain a DAG- and Ca2+-independent, atypical PKC isozyme (PKC-zeta), which does not decrease in expression after prolonged DAMGO or phorbol ester treatment.
Gene_expression (expressing) of PKC in SH-SY5Y associated with kinase c
4) Confidence 0.58 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.06 Pain Relevance 1.75
PKC may then translocate to various cellular sites including the mitochondria, sarcolemma and intercalated discs, and nucleus, a phenomena that may involve specific PKC isoforms, where p38MAPK will be activated.
Gene_expression (isoforms) of PKC in nucleus associated with kinase c
5) Confidence 0.57 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.35
1-adrenoreceptors) mitoKATP channels are opened via Gi proteins and PKC, possibly PKC-?
Spec (possibly) Gene_expression (possibly) of PKC associated with kinase c
6) Confidence 0.57 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.32
1-adrenoreceptors) mitoKATP channels are opened via Gi proteins and PKC, possibly PKC-?
Spec (possibly) Gene_expression (possibly) of PKC associated with kinase c
7) Confidence 0.57 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.32
Lipid body formation develops rapidly by processes that involve PKC, PLC, and de novo mRNA and protein synthesis.
Gene_expression (synthesis) of PKC in body
8) Confidence 0.55 Published 1997 Journal Mem. Inst. Oswaldo Cruz Section Abstract Doc Link 9698925 Disease Relevance 0.08 Pain Relevance 0.13
In addition to expressing conventional (PKC-alpha) and novel (PKC-epsilon) isoforms, SH-SY5Y cells also contain a DAG- and Ca2+-independent, atypical PKC isozyme (PKC-zeta), which does not decrease in expression after prolonged DAMGO or phorbol ester treatment.
Gene_expression (expressing) of PKC in SH-SY5Y associated with kinase c
9) Confidence 0.52 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.06 Pain Relevance 1.69
Of nine PKC isoforms co-expressed with UGT1A6 in human embryonic kidney 293T cells only PKC delta increased protein-normalized UGT1A6-mediated serotonin glucuronidation significantly (by 63% +/- 4%).
Gene_expression (co-expressed) of PKC in embryonic kidney associated with kinase c and serotonin
10) Confidence 0.45 Published 2010 Journal Xenobiotica Section Abstract Doc Link 20196639 Disease Relevance 0 Pain Relevance 0.85
Mutations of the overlapping X protein in rBDV-AASS are not involved in viral interference with PKC-dependent signaling
Gene_expression (signaling) of PKC-dependent associated with kinase c
11) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.36 Pain Relevance 0.17
Here, we tested the hypothesis that BDV phosphoprotein (P) may serve as a PKC decoy substrate when expressed in neurons, resulting in an interference with PKC-dependent signaling and impaired neuronal activity.
Gene_expression (expressed) of PKC in neuronal associated with virus diseases and kinase c
12) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 1.00 Pain Relevance 0.47
The S26/28A mutation of BDV P corrects the interference with PKC signaling
Gene_expression (signaling) of PKC associated with virus diseases and kinase c
13) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.54 Pain Relevance 0.20
Coinjection of nonhyperalgesic doses of PAR2 agonist and capsaicin induced hyperalgesia that was inhibited by deletion of TRPV1 or antagonism of PKC.
Gene_expression (deletion) of PKC associated with kinase c, hyperalgesia, qutenza and agonist
14) Confidence 0.39 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128844 Disease Relevance 0.41 Pain Relevance 1.66
We hypothesized that increased prostaglandin production by Cox-2 induces PKC and the expression of transcriptional factor c-Jun, which in turn, induces the expression of MDR1/Pgp170.
Gene_expression (expression) of PKC
15) Confidence 0.36 Published 2001 Journal Anticancer Res. Section Body Doc Link 11501838 Disease Relevance 0.07 Pain Relevance 0
Expression of Cox-2, MDR1/Pgp170, Protein Kinase C (PKC), and Activator Protein 1 (AP1) were investigated in a series of increasingly resistant human MCF-7 breast cancer cells compared to wild type using immunohistochemistry, Western blots, Northern blots, RT-PCR, and Southern blots.
Spec (investigated) Gene_expression (Expression) of PKC in MCF-7
16) Confidence 0.36 Published 2001 Journal Anticancer Res. Section Body Doc Link 11501838 Disease Relevance 0.09 Pain Relevance 0
Furthermore, PKC?
Gene_expression (Furthermore) of PKC
17) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.91 Pain Relevance 0.18
but not PKC?
Gene_expression (but) of PKC
18) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.91 Pain Relevance 0.18
An increased expression of PLC-beta3 and PKC-alpha and -beta2 was also evidentiated at the longer time points explored, when the effects of ATRA in preservation of the differentiated morphology were maximal.
Gene_expression (expression) of PKC-alpha
19) Confidence 0.21 Published 2003 Journal Int J Artif Organs Section Abstract Doc Link 12866655 Disease Relevance 0.08 Pain Relevance 0.09
The involvement of signaling pathways (JNK, p38, and Erk1/2 MAP-kinases, JAK2 and JAK3, PKC, and transcription factor NF-?
Gene_expression (kinases) of PKC
20) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.39 Pain Relevance 0.24

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