INT61190

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.40
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ggt1) transferase activity, transferring acyl groups (Ggt1)
Ggt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 42 98.44 Very High Very High Very High
cINOD 4 95.36 Very High Very High Very High
Bile 2 20.56 Low Low
tolerance 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nephrotoxicity 14 99.92 Very High Very High Very High
Infection 16 99.60 Very High Very High Very High
Hepatotoxicity 1 95.48 Very High Very High Very High
Necrosis 1 94.96 High High
Helminth Infection 1 89.40 High High
Granuloma 3 85.84 High High
Disease 2 84.80 Quite High
Fibrosis 1 81.12 Quite High
INFLAMMATION 2 75.00 Quite High
Schistosomiasis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ALT and GGT were not significantly decreased compared to their corresponding controls.
Neg (not) Negative_regulation (decreased) of GGT
1) Confidence 0.42 Published 2002 Journal Arzneimittelforschung Section Abstract Doc Link 12040972 Disease Relevance 1.13 Pain Relevance 0.30
Administration of the gamma-glutamyl transpeptidase inhibitor, L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydroxy- 5-isoxazoleacetic acid (AT-125) (50 mg/kg, ip), to mice 30 min before APAP significantly diminished the APAP-induced histopathologic damage and BUN elevation.
Negative_regulation (inhibitor) of gamma-glutamyl transpeptidase associated with paracetamol
2) Confidence 0.32 Published 1996 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 8560470 Disease Relevance 0.22 Pain Relevance 0.65
Inhibitors of either gamma-glutamyl transpeptidase (gamma-GT) or the probenecid-sensitive organic anion transporter ameliorate APAP-induced nephrotoxicity but not hepatotoxicity in mice and inhibition of gamma-GT similarly protected rats from APAP nephrotoxicity.
Negative_regulation (Inhibitors) of gamma-glutamyl transpeptidase associated with nephrotoxicity, paracetamol and hepatotoxicity
3) Confidence 0.23 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15629190 Disease Relevance 0.83 Pain Relevance 1.29
While traditional antibiotics usually exert their activities via a specific mode of action; for example, penicillin interferes with the cross-linking of two linear polymers by inhibiting the transpeptidase reaction, bacteriocins on the other hand have quite diverse activities.
Negative_regulation (inhibiting) of transpeptidase
4) Confidence 0.01 Published 2010 Journal Gut Pathog Section Body Doc Link PMC2912230 Disease Relevance 0.21 Pain Relevance 0

General Comments

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