INT612

Context Info Confidence 0.68 First Reported 1976 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 15 Total Number 15 Disease Relevance 5.24 Pain Relevance 6.73

transport (Orm1) extracellular space (Orm1) extracellular region (Orm1)

Anatomy Link Frequency liver 2 plasma 1 optic 1 urine 1 Orm1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat alcohol 2 100.00 Paracetamol 1 100.00 Inflammation 35 99.96 analgesia 10 99.58 lidocaine 13 99.52 methadone 25 99.38 tolerance 2 99.12 Arthritis 2 98.54 Analgesic 13 98.32 Pain 6 92.04

Disease Link Frequency Relevance Heat Injury 12 100.00 INFLAMMATION 29 99.96 Cv Unclassified Under Development 4 99.12 Amputation 2 98.72 Experimental Arthritis 2 98.54 Poisoning 1 97.96 Disease 4 97.64 Burns 4 97.02 Necrosis 2 94.92 Pain 4 92.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The purpose of this study was to determine the relationship between inflammation, increased alpha-1-acid glycoprotein (AAG), and lidocaine tolerance during fiber-optic bronchoscopy.

Positive_regulation (increased) of alpha-1-acid glycoprotein in optic associated with inflammation, tolerance and lidocaine

1) Confidence 0.68 Published 1987 Journal Respiration Section Abstract Doc Link 3563124 Disease Relevance 0.37 Pain Relevance 0.77

These results suggest that a decreased immediate response to i.v. methadone may occur in circumstances in which there is an increase in alpha 1 acid glycoprotein, but that this is not likely to be observed when the absorption is not instantaneous.

Positive_regulation (increase) of acid glycoprotein associated with methadone

2) Confidence 0.60 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7590118 Disease Relevance 0.39 Pain Relevance 0.99

AGP levels in both pretreated groups (TP and exo-AGP) were significantly increased, and the unbound fraction (fu) was decreased, compared to controls.

Positive_regulation (increased) of AGP

3) Confidence 0.60 Published 2004 Journal J Pharm Sci Section Abstract Doc Link 15452846 Disease Relevance 0.08 Pain Relevance 0.84

The alpha1 -acid glycoprotein concentrations were increased between days 2 and 10, with a peak on day 4 (6.52 +/- 1.45 mg/ml), and recovered to control values (0.61 +/- 0.33 mg/ml) on day 12.

Positive_regulation (increased) of acid glycoprotein

4) Confidence 0.59 Published 2003 Journal Anesthesiology Section Body Doc Link 12502983 Disease Relevance 0.06 Pain Relevance 0

AGP levels in both pretreated groups (TP and exo-AGP) were significantly increased, and the unbound fraction (fu) was decreased, compared to controls.

Positive_regulation (increased) of exo-AGP

5) Confidence 0.46 Published 2004 Journal J Pharm Sci Section Abstract Doc Link 15452846 Disease Relevance 0.08 Pain Relevance 0.83

AGP levels, in rats, were increased by two different methods: (a) experimental inflammation with turpentine oil (TP), and (b) by directly infusing the protein (exo-AGP).

Positive_regulation (increased) of AGP associated with inflammation

6) Confidence 0.41 Published 2004 Journal J Pharm Sci Section Abstract Doc Link 15452846 Disease Relevance 0.10 Pain Relevance 0.75

Our aims were to evaluate the processes (pharmacokinetics-PK and/or pharmacodynamics-PD) associated with changes of methadone analgesia under conditions of increased AGP, and whether these changes are dependent on binding, secondary to a pathology, or directly attributable to AGP.

Positive_regulation (increased) of AGP associated with methadone and analgesia

7) Confidence 0.41 Published 2004 Journal J Pharm Sci Section Abstract Doc Link 15452846 Disease Relevance 0.08 Pain Relevance 0.72

RESULTS: FCA injection led to the development of an acute inflammatory response evidenced by paw edema and increased alpha-1-acid glycoprotein (AGP) and total-nitrite (NOx) plasma concentrations.

Positive_regulation (increased) of AGP in plasma

8) Confidence 0.31 Published 2005 Journal Pharm. Res. Section Body Doc Link 15771231 Disease Relevance 0 Pain Relevance 0

The plasma AGP concentration in carbon tetrachloride (CCl4), allyl alcohol, bromobenzene, acetaminophen or N-nitrosodimethylamine-induced liver injury was increased to 2-3.5 times the normal level at 24 h after the intoxication.

Positive_regulation (increased) of AGP in liver associated with paracetamol, injury, poisoning and alcohol

9) Confidence 0.30 Published 1992 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1446373 Disease Relevance 0.78 Pain Relevance 0.19

For example albumin at the height of adjuvant arthritis falls to a third of its normal plasma level whereas the level of alpha1 acid glycoprotein increases up to twenty-fold; these changes are reflected by similar changes in their synthesis rate by the liver.

Positive_regulation (increases) of acid glycoprotein in liver associated with experimental arthritis and arthritis

10) Confidence 0.22 Published 1976 Journal Agents Actions Section Abstract Doc Link 60050 Disease Relevance 1.03 Pain Relevance 0.39

Alpha-1 acid glycoprotein levels were increased in patients and this effect was more pronounced in active disease (1802 +/- 1025 mg/l) than in remission (931 +/- 273 mg/l).

Positive_regulation (increased) of acid glycoprotein associated with disease

11) Confidence 0.19 Published 1992 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 1473877 Disease Relevance 0.50 Pain Relevance 0.33

In a group of 23 patients with postoperative necrotic complications, significant increases in CRP and AGP levels were found 7-10 days after surgery.

Positive_regulation (increases) of AGP

12) Confidence 0.16 Published 1993 Journal Eur J Vasc Surg Section Abstract Doc Link 8270063 Disease Relevance 0.66 Pain Relevance 0.28

The free fractions for these drugs decreased one week following the burn (imipramine, 0.074 vs. 0.095; lidocaine, 0.17 vs. 0.35; meperidine, 0.37 vs. 0.48; and propranolol, 0.045 vs. 0.107), presumably in response to the increased alpha-1 acid glycoprotein concentration (222 vs. 83 mg/dL, control).

Positive_regulation (increased) of alpha-1 acid glycoprotein associated with burns and lidocaine

13) Confidence 0.14 Published 1986 Journal J Clin Pharmacol Section Abstract Doc Link 3950058 Disease Relevance 0.37 Pain Relevance 0.34

Levels of CRP and AGP increased with the severity of ischaemia.

Positive_regulation (increased) of AGP associated with cv unclassified under development

14) Confidence 0.10 Published 1993 Journal Eur J Vasc Surg Section Abstract Doc Link 8270063 Disease Relevance 0.73 Pain Relevance 0.31

RESULTS: The pharmacokinetic profile of the active enantiomer of methadone, R -methadone, showed a relatively normal distribution with 38% to 90% of the interindividual variability in modeled pharmacokinetic parameters being explained by their individual variability in CYP3A activity, the cumulative amount of the main CYP3A4 metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrolidine, excreted in the urine, the fraction unbound in plasma, and the alpha1-AGP orosomucoid 2 (ORM2) variant plasma concentration.

Positive_regulation (variability) of alpha1-AGP in urine

15) Confidence 0.01 Published 2001 Journal Clin. Pharmacol. Ther. Section Body Doc Link 11452244 Disease Relevance 0 Pain Relevance 0

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