INT61225

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Context Info
Confidence 0.31
First Reported 1995
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 2.32
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1) aging (Cyp27b1)
cytoplasm (Cyp27b1)
Anatomy Link Frequency
liver 1
lung 1
reticulum 1
Cyp27b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 99.84 Very High Very High Very High
Paracetamol 32 98.64 Very High Very High Very High
Inflammation 4 75.68 Quite High
tricyclic antidepressant 1 73.92 Quite High
Pain 1 71.76 Quite High
agonist 32 71.56 Quite High
headache 2 62.32 Quite High
aspirin 1 30.96 Quite Low
imagery 8 23.76 Low Low
anesthesia 4 11.36 Low Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 9 96.04 Very High Very High Very High
Death 4 93.80 High High
Targeted Disruption 72 89.84 High High
Nicotine Addiction 32 88.80 High High
Malignant Neoplastic Disease 4 80.16 Quite High
Congenital Anomalies 4 78.16 Quite High
Toxicity 9 76.88 Quite High
INFLAMMATION 4 75.68 Quite High
Headache 2 62.32 Quite High
Gastrointestinal Disease 2 61.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblot analysis of microsomal proteins showed that rutaecarpine-treatment increased the protein levels of CYP1A1 and CYP1A2 in the liver, whereas hepatic level of CYP3A-immunoreacted protein was not affected by rutaecarpine.
Positive_regulation (increased) of CYP1A1 in liver
1) Confidence 0.31 Published 2001 Journal Life Sci. Section Abstract Doc Link 11787945 Disease Relevance 0.12 Pain Relevance 0.06
The co-segregation of elevated basal Cyp1a1 and CYP1a2 gene expression levels in animals selected for susceptibility to acetaminophen-induced hepatotoxicity suggested a common heritable basis for regulation of basal expression of both of these CYP1A isoforms.
Positive_regulation (elevated) of Cyp1a1 associated with paracetamol and hepatotoxicity
2) Confidence 0.20 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.17 Pain Relevance 0.39
Further examination of both CYP1A isoforms revealed that hepatic CYP1A1 and CYP1A2 mRNA and protein levels were significantly elevated in animals from the susceptible group.
Positive_regulation (elevated) of CYP1A1
3) Confidence 0.20 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.20 Pain Relevance 0.51
Ethoxyresorufin O-deethylase activity, associated with both CYP1A1 and CYP1A2, was also significantly elevated in this group.
Positive_regulation (elevated) of CYP1A1
4) Confidence 0.13 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.19 Pain Relevance 0.51
However, these mice have been used only to investigate activation of AhR or the Cyp1a1 promoter in specific organs or tissues after oral or ip administration of halogenated and polycyclic aromatic hydrocarbons.
Spec (investigate) Positive_regulation (activation) of Cyp1a1
5) Confidence 0.10 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.48 Pain Relevance 0
This molecular event results in transcriptional induction of downstream genes such as cytochrome P4501A1 (CYP1A1) that may generate mutagenic metabolites and reactive oxygen species (Nebert et al. 2000), leading to cellular activation, dysfunction, and/or programmed death.
Positive_regulation (induction) of CYP1A1 associated with death
6) Confidence 0.10 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.56 Pain Relevance 0.04
Notably, induction of Cyp1a1 was also observed in some of the other organs tested.
Positive_regulation (induction) of Cyp1a1
7) Confidence 0.07 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.27 Pain Relevance 0.03
Induction of SEAP in the lung correlated with induction of Cyp1a1, an AhR-dependent gene (Figure 5D).
Positive_regulation (induction) of Cyp1a1 in lung
8) Confidence 0.07 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.21 Pain Relevance 0.04
In support of these results, COS cell transfection experiments show that phosphomimetic mutation Thr-35 --> Asp or induced cellular PKC caused increased CYP1A1 targeting to MT and correspondingly lower levels to the endoplasmic reticulum.
Positive_regulation (increased) of CYP1A1 in reticulum associated with kinase c
9) Confidence 0.06 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899466 Disease Relevance 0 Pain Relevance 0.28
C57BL/6 and DBA/2 mice are, respectively, susceptible and resistant both to the induction of aryl hydrocarbon hydroxylase (cytochrome P450 1A1, or CYP1A1) and to the cataractogenicity of acetaminophen, which may involve its bioactivation to a toxic reactive intermediate, catalysed by P450 and (or) prostaglandin H synthase (PHS).
Positive_regulation (induction) of CYP1A1 associated with paracetamol
10) Confidence 0.04 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8564879 Disease Relevance 0 Pain Relevance 0.31
Immunoblot analyses showed that methanol extract increased the levels of CYP1A1, CYP1A2, CYP2B-, and GSTYb-immunoreactive proteins.
Positive_regulation (increased) of CYP1A1
11) Confidence 0.03 Published 2002 Journal Life Sci. Section Abstract Doc Link 12106592 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

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