INT61231

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 30
Disease Relevance 3.01
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SULT1A1) small molecule metabolic process (SULT1A1) cytoplasm (SULT1A1)
Anatomy Link Frequency
liver 4
MCF-7 1
platelet 1
SULT1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 18 99.84 Very High Very High Very High
Dopamine 14 98.90 Very High Very High Very High
local anesthetic 17 97.84 Very High Very High Very High
Paracetamol 23 96.92 Very High Very High Very High
Catecholamine 9 96.00 Very High Very High Very High
headache 51 88.16 High High
Piles 68 85.92 High High
Neurotransmitter 3 71.52 Quite High
Morphine 3 69.60 Quite High
sodium channel 17 61.76 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 6 96.64 Very High Very High Very High
Shellfish Poisoning 187 93.64 High High
Toxicity 210 93.28 High High
Tension-type Headache 34 88.16 High High
Anorectal Disorders 68 85.92 High High
Poisoning 34 80.08 Quite High
Death 37 75.64 Quite High
Bacterial Infection 2 59.92 Quite High
Sprains And Strains 54 56.28 Quite High
Arthralgia 17 50.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies of 3-OH-BaP sulfonation by expressed human SULT1A1*1, SULT1A1*2, SULT1B1, and SULT1E1 showed that triclosan inhibited the activities of each of these purified enzymes with IC50 concentrations between 2.09 and 7.5 microM.
Gene_expression (expressed) of SULT1A1
1) Confidence 0.75 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 15269185 Disease Relevance 0.06 Pain Relevance 0.24
Studies of 3-OH-BaP sulfonation by expressed human SULT1A1*1, SULT1A1*2, SULT1B1, and SULT1E1 showed that triclosan inhibited the activities of each of these purified enzymes with IC50 concentrations between 2.09 and 7.5 microM.
Gene_expression (expressed) of SULT1A1
2) Confidence 0.75 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 15269185 Disease Relevance 0.06 Pain Relevance 0.24
The ability of hM-PST to sulfate a number of xenobiotics was examined and compared with the bacterially expressed human phenol-sulfating form of PST (hP-PST).
Gene_expression (expressed) of PST
3) Confidence 0.66 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565785 Disease Relevance 0.09 Pain Relevance 0.24
Expressed hM-PST was very similar to the brain, intestinal, and platelet forms of the enzyme in its physical, immunological, and kinetic properties.
Gene_expression (Expressed) of PST in platelet
4) Confidence 0.66 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565785 Disease Relevance 0.10 Pain Relevance 0.15
The ability of hM-PST to sulfate a number of xenobiotics was examined and compared with the bacterially expressed human phenol-sulfating form of PST (hP-PST).
Gene_expression (expressed) of PST
5) Confidence 0.66 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565785 Disease Relevance 0.09 Pain Relevance 0.24
RESULTS: Of 10 heterologously expressed SULT isoforms examined, SULT1A1, SULT1A3/4, SULT1E1, and SULT2A1 all catalyzed the formation of APAP sulfate with K(m) values of 2.4, 1.5, 1.9, and 3.7 mM, respectively.
Gene_expression (expressed) of SULT1A1
6) Confidence 0.63 Published 2008 Journal Birth Defects Res. Part A Clin. Mol. Teratol. Section Body Doc Link 18232020 Disease Relevance 0 Pain Relevance 0
In MCF-7 cells stably expressing either SULT1A1*1 or *2, the antiestrogenic response to OHT was found to be allele-specific: the cells expressing *2 exhibited a better antiproliferative response.
Gene_expression (expressing) of SULT1A1 in MCF-7
7) Confidence 0.60 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16517757 Disease Relevance 0 Pain Relevance 0.11
Comparison of the residues in the substrate binding loops of SULT1A1 and SULT1A3 revealed that all residues are identical (and in identical positions in the structures) except for the eight residues shown in Figure 9.
Gene_expression (loops) of SULT1A1
8) Confidence 0.57 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0.17
The translation product of the T47D hM-PST cDNA was 92% identical to that of liver hP-PST.
Gene_expression (product) of PST in liver
9) Confidence 0.57 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565785 Disease Relevance 0.08 Pain Relevance 0.25
The translation product of the T47D hM-PST cDNA was 92% identical to that of liver hP-PST.
Gene_expression (product) of PST in liver
10) Confidence 0.57 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565785 Disease Relevance 0.08 Pain Relevance 0.25
Monoamine neurotransmittors, such as epinephrine and dopamine, were maximally conjugated at lower concentrations by expressed hM-PST (2 and 20 microM, respectively) than by hP-PST (1 and 1 mM, respectively).
Gene_expression (expressed) of PST associated with dopamine and monoamine
11) Confidence 0.51 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565785 Disease Relevance 0.08 Pain Relevance 0.26
Consistent with its role in drug metabolism, SULT1A1 is abundantly expressed in liver, although it is also expressed in numerous extrahepatic tissues [5].
Gene_expression (expressed) of SULT1A1 in liver
12) Confidence 0.33 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.10
Novel analogs could also be devised by redesigning PST biosynthesis genes in amenable host systems via combinatorial biosynthesis.


Gene_expression (biosynthesis) of PST
13) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.17 Pain Relevance 0.16
Similarly, the recently identified M-toxins (M1-5) are reportedly bivalve metabolites of the PSTs and are not present in PST- producing microalgae [56].
Neg (not) Gene_expression (producing) of PST
14) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0 Pain Relevance 0
Harlow et al. were able to use degenerate primers to screen several dinoflagellate genomes in an attempt to identify genes encoding SAM as a candidate involved in PST biosynthesis [138].
Gene_expression (biosynthesis) of PST
15) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.06 Pain Relevance 0
The authors therefore suggested a possible cyanobacterial source, though neither a definitive chemical structure, nor a PST-producing organism were conclusively identified [86].
Gene_expression (producing) of PST
16) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.06 Pain Relevance 0
Future research is also needed to understand the integration of PST biosynthesis within the overall cell metabolism and the possible recruitment of enzymes from other biosynthetic pathways for PST bioconversions.
Gene_expression (biosynthesis) of PST
17) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0 Pain Relevance 0
Although several SAM genes were successfully identified within dinoflagellates, these were not correlated to PST biosynthesis.
Gene_expression (biosynthesis) of PST
18) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.05 Pain Relevance 0
Cyanobacterial PST producing blooms result in the contamination of drinking and recreational water resources.
Gene_expression (producing) of PST
19) Confidence 0.09 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.36 Pain Relevance 0
In future, characterization of PST biosynthetic genes from dinoflagellates and comparison with cyanobacterial genes will also aid in our understanding of the evolutionary history of these genes with regard to their origin and transfer.
Gene_expression (biosynthetic) of PST
20) Confidence 0.08 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.08 Pain Relevance 0

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