INT61237

Context Info Confidence 0.63 First Reported 1995 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 1.01 Pain Relevance 0.96

oxidoreductase activity (Cyp3a2) endoplasmic reticulum (Cyp3a2) enzyme binding (Cyp3a2) cytoplasm (Cyp3a2)

Anatomy Link Frequency liver 1 Cyp3a2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Taxol 6 99.32 Paracetamol 11 98.00 dexamethasone 4 82.72 lidocaine 1 70.04 cINOD 1 57.00

Disease Link Frequency Relevance Heat Infection 2 99.64 Toxicity 6 98.36 Hepatocellular Cancer 1 98.36 Hepatotoxicity 3 88.48 Hypertrophy 1 72.88 INFLAMMATION 1 56.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Taxol caused a concentration-dependent increase in the amount of immunoreactive CYP3A and in the steady-state levels of CYP3A1/DEX but not CYP3A2 mRNA.

Positive_regulation (increase) of CYP3A2 associated with taxol

1) Confidence 0.63 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9007036 Disease Relevance 0.39 Pain Relevance 0.77

Caffeine and 7,8-benzoflavone activate CYP3A2 in rat liver microsomes.

Positive_regulation (activate) of CYP3A2 in liver

2) Confidence 0.62 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9321518 Disease Relevance 0 Pain Relevance 0.06

This pretreatment regimen caused marked increases in immunochemically determined levels of CYP2A1, CYP2B1, CYP2B2, CYP2C6, and CYP3A2, and in the activities of 2 alpha-, 2 beta-, 6 beta-, 7 alpha-, 16 alpha-, and 16 beta-hydroxylation and 17-oxidation of testosterone.

Spec (determined) Positive_regulation (increases) of CYP3A2

3) Confidence 0.61 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565792 Disease Relevance 0 Pain Relevance 0.07

After 3days infection of AdCYP3A4, the testosterone 6beta-hydroxylase activity reached to 325pmol/min/mg protein in H4IIE (rat hepatoma) cells.

Positive_regulation (reached) of testosterone 6beta-hydroxylase associated with hepatocellular cancer and infection

4) Confidence 0.45 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19958826 Disease Relevance 0.49 Pain Relevance 0

Tebufelone treatment increased NADPH-dependent cytochrome c reductase, total P450, and indicators of CYP2B11 (chloramphenicol covalent binding and immunochemically determined 2B11) and CYP3A12 (erythromycin N-demethylase, triacetyloleandomycin spectral complex formation, testosterone 6 beta-hydroxylase, and immunochemically determined 3A12).

Positive_regulation (increased) of testosterone 6 beta-hydroxylase

5) Confidence 0.05 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8723731 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

This test has worked.