INT61237

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Context Info
Confidence 0.63
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.01
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a2) endoplasmic reticulum (Cyp3a2) enzyme binding (Cyp3a2)
cytoplasm (Cyp3a2)
Anatomy Link Frequency
liver 1
Cyp3a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Taxol 6 99.32 Very High Very High Very High
Paracetamol 11 98.00 Very High Very High Very High
dexamethasone 4 82.72 Quite High
lidocaine 1 70.04 Quite High
cINOD 1 57.00 Quite High
Disease Link Frequency Relevance Heat
Infection 2 99.64 Very High Very High Very High
Toxicity 6 98.36 Very High Very High Very High
Hepatocellular Cancer 1 98.36 Very High Very High Very High
Hepatotoxicity 3 88.48 High High
Hypertrophy 1 72.88 Quite High
INFLAMMATION 1 56.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taxol caused a concentration-dependent increase in the amount of immunoreactive CYP3A and in the steady-state levels of CYP3A1/DEX but not CYP3A2 mRNA.
Positive_regulation (increase) of CYP3A2 associated with taxol
1) Confidence 0.63 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9007036 Disease Relevance 0.39 Pain Relevance 0.77
Caffeine and 7,8-benzoflavone activate CYP3A2 in rat liver microsomes.
Positive_regulation (activate) of CYP3A2 in liver
2) Confidence 0.62 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9321518 Disease Relevance 0 Pain Relevance 0.06
This pretreatment regimen caused marked increases in immunochemically determined levels of CYP2A1, CYP2B1, CYP2B2, CYP2C6, and CYP3A2, and in the activities of 2 alpha-, 2 beta-, 6 beta-, 7 alpha-, 16 alpha-, and 16 beta-hydroxylation and 17-oxidation of testosterone.
Spec (determined) Positive_regulation (increases) of CYP3A2
3) Confidence 0.61 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565792 Disease Relevance 0 Pain Relevance 0.07
After 3days infection of AdCYP3A4, the testosterone 6beta-hydroxylase activity reached to 325pmol/min/mg protein in H4IIE (rat hepatoma) cells.
Positive_regulation (reached) of testosterone 6beta-hydroxylase associated with hepatocellular cancer and infection
4) Confidence 0.45 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19958826 Disease Relevance 0.49 Pain Relevance 0
Tebufelone treatment increased NADPH-dependent cytochrome c reductase, total P450, and indicators of CYP2B11 (chloramphenicol covalent binding and immunochemically determined 2B11) and CYP3A12 (erythromycin N-demethylase, triacetyloleandomycin spectral complex formation, testosterone 6 beta-hydroxylase, and immunochemically determined 3A12).
Positive_regulation (increased) of testosterone 6 beta-hydroxylase
5) Confidence 0.05 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8723731 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

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