INT61240

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Context Info
Confidence 0.54
First Reported 1995
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.26
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2a1) endoplasmic reticulum (Cyp2a1)
Cyp2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 3 91.24 High High
cytokine 1 80.00 Quite High
lidocaine 1 68.40 Quite High
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 10 99.32 Very High Very High Very High
Injury 2 92.88 High High
Viral Infection 2 49.84 Quite Low
Hepatotoxicity 5 25.00 Low Low
Toxicity 4 13.84 Low Low
Adenovirus Infection 7 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Pulmonary Disease 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This pretreatment regimen caused marked increases in immunochemically determined levels of CYP2A1, CYP2B1, CYP2B2, CYP2C6, and CYP3A2, and in the activities of 2 alpha-, 2 beta-, 6 beta-, 7 alpha-, 16 alpha-, and 16 beta-hydroxylation and 17-oxidation of testosterone.
Spec (determined) Gene_expression (levels) of CYP2A1
1) Confidence 0.54 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565792 Disease Relevance 0 Pain Relevance 0.07
By comparison, the effects of allylthiobenzimidazole (ATB) on the levels of several hepatic cytochrome P450, microsomal epoxide hydrolase (mEH) and GST expression have been studied in the rat herein. 2.
Gene_expression (expression) of hepatic cytochrome P450
2) Confidence 0.06 Published 1998 Journal Xenobiotica Section Abstract Doc Link 9574820 Disease Relevance 0.09 Pain Relevance 0.09
Microbial infection can significantly compromise the expression and function of hepatic cytochrome P450 enzymes, responsible for catalyzing biochemical processes necessary to maintain physiological homeostasis and conversion of medicinal agents to pharmacologically or toxicologically active metabolites [5,6].
Gene_expression (expression) of hepatic cytochrome P450 associated with infection
3) Confidence 0.05 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.17 Pain Relevance 0.04

General Comments

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