INT61243

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Context Info
Confidence 0.66
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 2.25
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a2) endoplasmic reticulum (Cyp3a2) enzyme binding (Cyp3a2)
cytoplasm (Cyp3a2)
Cyp3a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Oxycodone 8 99.62 Very High Very High Very High
MU agonist 2 98.12 Very High Very High Very High
Opioid 2 93.28 High High
Inflammatory stimuli 7 91.32 High High
cytokine 7 91.28 High High
lidocaine 1 68.40 Quite High
Inflammation 7 67.92 Quite High
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Viral Infection 14 99.84 Very High Very High Very High
Infection 70 98.52 Very High Very High Very High
Adenovirus Infection 49 97.64 Very High Very High Very High
INFLAMMATION 21 91.00 High High
Toxicity 28 89.32 High High
Lower Respiratory Tract Infection 7 88.96 High High
Targeted Disruption 7 84.48 Quite High
Adverse Drug Reaction 7 74.00 Quite High
Hepatotoxicity 21 62.24 Quite High
Pulmonary Disease 7 27.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated administration of oxycodone modifies the gene expression of several drug metabolising enzymes in the hepatic tissue of male Sprague-Dawley rats, including glutathione S-transferase A-5 (rGSTA5) and CYP3A2.
Gene_expression (expression) of CYP3A2 associated with oxycodone
1) Confidence 0.66 Published 2010 Journal J. Pharm. Pharmacol. Section Title Doc Link 20487198 Disease Relevance 0 Pain Relevance 0.57
CONCLUSIONS: Repeated oxycodone administration is associated with a significant up-regulation of rGSTA5 and concomitant down-regulation of CYP3A2 mRNA, protein expression and functionality.
Gene_expression (expression) of CYP3A2
2) Confidence 0.66 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487198 Disease Relevance 0 Pain Relevance 0
Recombinant adenoviruses were chosen as model pathogens to further define processes by which viral infection alters expression of CYP3A2 and 2C11 for several reasons.
Gene_expression (expression) of CYP3A2 associated with viral infection
3) Confidence 0.65 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.70 Pain Relevance 0.07
Although much is known about the regulatory processes associated with CYP3A2 and 2C11 expression, the exact mechanism by which virus infection alters these metabolic enzymes is currently unknown.
Gene_expression (expression) of CYP3A2 associated with infection
4) Confidence 0.65 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.70 Pain Relevance 0.08
This pretreatment regimen caused marked increases in immunochemically determined levels of CYP2A1, CYP2B1, CYP2B2, CYP2C6, and CYP3A2, and in the activities of 2 alpha-, 2 beta-, 6 beta-, 7 alpha-, 16 alpha-, and 16 beta-hydroxylation and 17-oxidation of testosterone.
Spec (determined) Gene_expression (levels) of CYP3A2
5) Confidence 0.53 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565792 Disease Relevance 0 Pain Relevance 0.07
We have found that a single dose of recombinant adenovirus significantly suppresses CYP3A2 and 2C11 expression and function in the male Sprague-Dawley rat for 14 days, long after the innate immune response against the virus resolves [9].
Gene_expression (expression) of CYP3A2
6) Confidence 0.50 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.20 Pain Relevance 0.05
Given that CYP3A2 continued to be suppressed in all groups given active virus beyond 24 hours, we believe that changes in CYP3A2 expression and function may not be mediated by changes in PXR during adenovirus infection.
Gene_expression (expression) of CYP3A2 associated with adenovirus infection
7) Confidence 0.50 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.31 Pain Relevance 0
Hepatic CYP3A2 protein expression, catalytic activity, and mRNA levels were analyzed at 0.25, 1, 4, and 14 days after administration of either wild type virus or several different recombinant adenoviruses.
Spec (analyzed) Gene_expression (expression) of CYP3A2 protein
8) Confidence 0.50 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.08 Pain Relevance 0
Administration of helper-dependent adenovirus (HDAd), devoid of all viral genes and significantly less immunogenic than wild type or first generation adenoviruses [17,23], suppressed CYP3A2 protein, activity, and gene expression for 14 days (Figures 1, 2, 3, p ?
Gene_expression (expression) of CYP3A2 protein
9) Confidence 0.50 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.17 Pain Relevance 0.03
Effect of administration of recombinant adenoviruses on hepatic CYP3A2 expression and function
Gene_expression (expression) of CYP3A2
10) Confidence 0.50 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.09 Pain Relevance 0

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