INT61245

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 0.41
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2b2) aging (Cyp2b2) endoplasmic reticulum (Cyp2b2)
Anatomy Link Frequency
CAR 2
Cyp2b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 17 99.96 Very High Very High Very High
Inflammation 12 99.80 Very High Very High Very High
antidepressant 28 99.68 Very High Very High Very High
sSRI 24 99.56 Very High Very High Very High
fluoxetine 12 98.88 Very High Very High Very High
anticonvulsant 2 98.52 Very High Very High Very High
Desipramine 16 98.28 Very High Very High Very High
Morphine 3 89.20 High High
Serotonin 4 84.40 Quite High
Endep 4 80.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.80 Very High Very High Very High
Hypertrophy 2 99.46 Very High Very High Very High
Toxicity 23 83.36 Quite High
Shock 2 41.12 Quite Low
Nephrotoxicity 2 29.52 Quite Low
Porphyria 3 13.76 Low Low
Stress 10 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, two different mechanisms of the antidepressant-CYP2B interaction are postulated: 1) a direct inhibition of CYP2B shown in vitro by nefazodone, SSRIs and TADs; 2) in vivo induction of CYP2B produced by prolonged administration of SSRIs and desipramine, which suggests their influence on enzyme regulation.
Positive_regulation (induction) of CYP2B associated with desipramine, antidepressant and ssri
1) Confidence 0.64 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211989 Disease Relevance 0 Pain Relevance 0.85
Chronic treatment with the antidepressants led to a significant enhancement of CYP2B activity after sertraline, fluoxetine and desipramine (580, 200 and 150% of the control, respectively) treatment, which positively correlated with the observed elevation in CYP2B protein levels.
Positive_regulation (enhancement) of CYP2B associated with desipramine, antidepressant and fluoxetine
2) Confidence 0.64 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211989 Disease Relevance 0 Pain Relevance 0.90
After a one-day exposure of rats to the investigated antidepressants, a significant increase in CYP2B activity was only observed after sertraline exposure (300% of the control).
Positive_regulation (increase) of CYP2B associated with antidepressant
3) Confidence 0.64 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211989 Disease Relevance 0 Pain Relevance 0.86
This pretreatment regimen caused marked increases in immunochemically determined levels of CYP2A1, CYP2B1, CYP2B2, CYP2C6, and CYP3A2, and in the activities of 2 alpha-, 2 beta-, 6 beta-, 7 alpha-, 16 alpha-, and 16 beta-hydroxylation and 17-oxidation of testosterone.
Spec (determined) Positive_regulation (increases) of CYP2B2
4) Confidence 0.64 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565792 Disease Relevance 0 Pain Relevance 0.07
Chronic treatment with the antidepressants led to a significant enhancement of CYP2B activity after sertraline, fluoxetine and desipramine (580, 200 and 150% of the control, respectively) treatment, which positively correlated with the observed elevation in CYP2B protein levels.
Spec (observed) Positive_regulation (elevation) of CYP2B associated with desipramine, antidepressant and fluoxetine
5) Confidence 0.43 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211989 Disease Relevance 0 Pain Relevance 0.93
The PB-induced up-regulation of CYP2B, CYP2E1 and CYP1A1 isozymes was markedly higher in CD than in NF rats.
Positive_regulation (up-regulation) of CYP2B
6) Confidence 0.05 Published 2009 Journal J Appl Toxicol Section Abstract Doc Link 18798224 Disease Relevance 0 Pain Relevance 0.62
Rats treated with quinoline, and to a lesser extent, isoquinoline (75 mg/kg, daily for 3 days) showed induction of phase II drug metabolizing enzyme activities without inducing either cytochrome P450 concentration or CYP1A-, CYP2B-, CYP2E-, and CYP3A-selective activities.
Neg (without) Positive_regulation (inducing) of CYP2B
7) Confidence 0.05 Published 1997 Journal Chem. Biol. Interact. Section Abstract Doc Link 9134007 Disease Relevance 0 Pain Relevance 0.09
For the PB-induction of CYP2B, the rats were i.p. injected with PB at ZT8 and ZT20 and sacrificed at ZT13 and ZT1, respectively.
Positive_regulation (induction) of CYP2B
8) Confidence 0.04 Published 2004 Journal Nucl Recept Section Body Doc Link PMC517509 Disease Relevance 0 Pain Relevance 0
Diurnal difference in the induction of CYP2B by phenobarbital
Positive_regulation (induction) of CYP2B
9) Confidence 0.02 Published 2004 Journal Nucl Recept Section Body Doc Link PMC517509 Disease Relevance 0 Pain Relevance 0
Since CAR is associated with the induction of metabolic enzymes such as CYP2B, CYP3A, and UGT1A1, the circadian rhythmicity of CAR mRNA expression may be reflected in the diurnal-difference of PB-induction of CYP2B1/2 mRNA.
Positive_regulation (induction) of CYP2B in CAR
10) Confidence 0.02 Published 2004 Journal Nucl Recept Section Body Doc Link PMC517509 Disease Relevance 0 Pain Relevance 0
Stimulation of glutathione depletion and inflammation by APAP, induction of Cyp2b and Cyp3a genes, induction of PPAR?
Positive_regulation (induction) of Cyp2b associated with paracetamol and inflammation
11) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956103 Disease Relevance 0.10 Pain Relevance 0.34
For example, administration of anticonvulsant phenobarbital to rats causes liver hypertrophy, which is associated with induction of hepatic drug metabolizing enzymes such as CYP2B and CYP3A through the activation of the nuclear receptor CAR [4].
Positive_regulation (induction) of CYP2B in CAR associated with hypertrophy and anticonvulsant
12) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956103 Disease Relevance 0.31 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox