INT6125

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 9.17
Pain Relevance 9.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (Ahsp) cytoplasm (Ahsp)
Anatomy Link Frequency
endothelium 12
endothelial cells 3
vessels 3
blood vessels 2
venules 2
Ahsp (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 71 99.60 Very High Very High Very High
Pain 4 99.48 Very High Very High Very High
depression 20 99.46 Very High Very High Very High
ischemia 8 98.88 Very High Very High Very High
anesthesia 10 98.32 Very High Very High Very High
Angina 4 98.20 Very High Very High Very High
antagonist 13 97.04 Very High Very High Very High
adenocard 8 96.40 Very High Very High Very High
agonist 60 96.20 Very High Very High Very High
Calcium channel 1 93.48 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 11 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 25 99.66 Very High Very High Very High
Pain 3 99.48 Very High Very High Very High
Depression 20 99.46 Very High Very High Very High
Hypertension 24 99.28 Very High Very High Very High
Myocardial Infarction 8 98.92 Very High Very High Very High
Cv Unclassified Under Development 8 98.88 Very High Very High Very High
Hypotension 10 98.72 Very High Very High Very High
Cv General 3 Under Development 4 98.20 Very High Very High Very High
Pressure And Volume Under Development 3 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After Furchgott and Zawadzki [9] revealed in 1980 that an endothelium-derived relaxing factor (EDRF) is released from vascular endothelium, Palmer et al. [10] proved in 1987 that the EDRF was nitric oxide (NO).
Localization (released) of EDRF in endothelium
1) Confidence 0.78 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.19 Pain Relevance 0.11
Our results suggest instead that this endothelium-dependent inhibition is due to spontaneous release of EDRF, which results in tonic elevation of cGMP in the vascular smooth muscle.
Localization (release) of EDRF in endothelium
2) Confidence 0.70 Published 1987 Journal Mol. Pharmacol. Section Abstract Doc Link 2885738 Disease Relevance 0 Pain Relevance 0.51
The results indicate that chronic EtOH consumption significantly potentiates alpha-adrenergic-induced contractions in rat aortic rings, probably through interference with the production and/or the release of EDRF.
Localization (release) of EDRF
3) Confidence 0.70 Published 1992 Journal Gen. Pharmacol. Section Abstract Doc Link 1322338 Disease Relevance 0.08 Pain Relevance 0.06
pH-dependent release of EDRF from rabbit aortic endothelium.
Localization (release) of EDRF in endothelium
4) Confidence 0.69 Published 1990 Journal Pol J Pharmacol Pharm Section Title Doc Link 2175893 Disease Relevance 0 Pain Relevance 0.09
Endothelium-derived relaxing factors (EDRFs) have been previously shown to exert an inhibitory influence on the contractile effects of alpha-adrenoceptor agonists in vascular smooth muscle. alpha 2-Adrenoceptor agonists such as clonidine have been reported to be particularly susceptible to this effect, and it has been suggested that clonidine acts on alpha 2 receptors on endothelial cells to stimulate the release of EDRF.
Localization (release) of EDRF in endothelial cells associated with agonist and clonidine
5) Confidence 0.66 Published 1987 Journal Mol. Pharmacol. Section Abstract Doc Link 2885738 Disease Relevance 0 Pain Relevance 0.37
EDRF release is known to be accompanied by increased levels of cGMP in many blood vessels, and it is suggested that cGMP exerts an inhibitory influence on the smooth muscle cells, which tends to counteract the contractile effect of the clonidine.
Localization (release) of EDRF in blood vessels associated with clonidine
6) Confidence 0.66 Published 1987 Journal Mol. Pharmacol. Section Abstract Doc Link 2885738 Disease Relevance 0 Pain Relevance 0.37
Many of the circulating algesic agents released in response to ischemia produce a profound vasodilatation possibly through the release of an endothelium-derived relaxing factor (EDRF) as well as pain.
Localization (release) of EDRF in endothelium associated with pain, ischemia and increased venous pressure under development
7) Confidence 0.62 Published 1990 Journal Brain Res. Section Abstract Doc Link 2289134 Disease Relevance 0.46 Pain Relevance 0.15
An inhibitor of endothelium-derived relaxing factor (EDRF) synthase, N omega-nitro-L-arginine methyl ester (L-NAME) (0.65 mM), enhanced the veratridine-induced contraction in rings with an intact endothelium, which suggests that EDRF was being released during the veratridine-induced contraction.
Localization (released) of EDRF in endothelium
8) Confidence 0.54 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1667387 Disease Relevance 0 Pain Relevance 0.19
The overall study indicated that communication from venules to arterioles through the release of EDRF from the venule did occur and caused substantial arteriolar vasodilation.
Localization (release) of EDRF in venule associated with increased venous pressure under development
9) Confidence 0.54 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2337183 Disease Relevance 0.10 Pain Relevance 0.12
Thus, a stimulation of EDRF release contributes to the LPS-induced hypotension in the anaesthetized rat.
Localization (release) of EDRF associated with hypotension
10) Confidence 0.48 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2226626 Disease Relevance 0.26 Pain Relevance 0
Communication from venules to arterioles through the release of endothelial-derived relaxing factor (EDRF) was evaluated.
Localization (release) of EDRF in venules
11) Confidence 0.48 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2337183 Disease Relevance 0 Pain Relevance 0.03
If a vasodilator induces release of EDRF from the epithelium it is classified as endothelium-dependent, if not it is independent.
Localization (release) of EDRF in epithelium
12) Confidence 0.40 Published 1989 Journal Ann Cardiol Angeiol (Paris) Section Abstract Doc Link 2629613 Disease Relevance 0.25 Pain Relevance 0.19
EDRF release, vasodilator capacity, and antiaggregant effects are reduced when LDL is high.
Localization (release) of EDRF
13) Confidence 0.30 Published 1988 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 3154691 Disease Relevance 0.32 Pain Relevance 0.16
Because the administration of this substance inhibits the release of EDRF-NO, it appears that this paracrine endothelial hormone actively dilates the normal circulation.
Localization (release) of EDRF-NO
14) Confidence 0.29 Published 1991 Journal Med. Clin. North Am. Section Abstract Doc Link 2020228 Disease Relevance 0.37 Pain Relevance 0.32
Therefore nitrates may particularly be effective in vessels with deficient EDRF release.
Localization (release) of EDRF in vessels
15) Confidence 0.27 Published 1988 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 3154691 Disease Relevance 0.24 Pain Relevance 0.07
In endothelium-denuded vessels relaxation was absent. 5-HT-induced relaxation of precontracted pulmonary arteries was probably mediated by release of an endothelium-derived relaxing factor (EDRF).
Localization (release) of EDRF in endothelium
16) Confidence 0.27 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8391650 Disease Relevance 0 Pain Relevance 0.10
These results suggest that enhanced responsiveness of arteries from diabetic animals to alpha-adrenoceptor stimulation is not the result of a decrease in endothelium-derived relaxing factor (EDRF) release in diabetic blood vessels.
Localization (release) of EDRF in blood vessels associated with diabetes mellitus
17) Confidence 0.27 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2850927 Disease Relevance 0.79 Pain Relevance 0.26
Because activation of alpha2-adrenoceptors on endothelial cells induces release of endothelium-derived relaxing factor (EDRF), we determined whether nitric oxide (NO) release is involved in the antihypertensive action of clonidine and rilmenidine.
Localization (release) of EDRF in endothelium associated with clonidine
18) Confidence 0.27 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10813383 Disease Relevance 0.21 Pain Relevance 0.44
This, in turn, stimulates EDRF (NO) release in epicardial arteries and dilation.
Localization (release) of EDRF
19) Confidence 0.27 Published 1988 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 3154691 Disease Relevance 0.29 Pain Relevance 0.20
In the same way, relaxation is explained by ACh-stimulated EDRF release, which is inhibited by L-NA.
Localization (release) of EDRF
20) Confidence 0.26 Published 1996 Journal Acta Physiol Pharmacol Ther Latinoam Section Abstract Doc Link 9222395 Disease Relevance 0 Pain Relevance 0.10

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