INT61252

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 38
Total Number 38
Disease Relevance 16.48
Pain Relevance 5.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
macrophages 17
neutrophil 14
microglia 11
brain 3
dendritic cells 2
Itgam (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 401 99.92 Very High Very High Very High
cytokine 331 98.88 Very High Very High Very High
narcan 9 98.76 Very High Very High Very High
Enkephalin 6 98.20 Very High Very High Very High
COX-2 inhibitor 19 96.24 Very High Very High Very High
agonist 33 95.16 Very High Very High Very High
opioid receptor 6 94.80 High High
Kappa opioid receptor 12 93.20 High High
cINOD 43 90.48 High High
Hippocampus 41 89.40 High High
Disease Link Frequency Relevance Heat
Adhesions 83 100.00 Very High Very High Very High
INFLAMMATION 620 99.92 Very High Very High Very High
Infection 1048 99.62 Very High Very High Very High
Disease 309 99.50 Very High Very High Very High
Targeted Disruption 111 99.36 Very High Very High Very High
Meningitis 617 99.00 Very High Very High Very High
Injury 119 94.60 High High
Leukemia 3 91.20 High High
Systemic Lupus Erythematosus 84 91.04 High High
Weight Loss 5 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
U-50,488H also decreased neutrophil expression of the beta(2) integrin CD11b/CD18 (Mac-1) and adhesion to plastic in a naloxone-reversible manner.
Negative_regulation (decreased) of Gene_expression (expression) of Mac-1 in neutrophil associated with narcan and adhesions
1) Confidence 0.54 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11239930 Disease Relevance 0.18 Pain Relevance 0.78
Interestingly, we detected no decrease in surface expression of CR3 or any of the Fc?
Neg (no) Negative_regulation (decrease) of Gene_expression (expression) of CR3
2) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.84 Pain Relevance 0.03
U-50,488H also decreased neutrophil expression of the beta(2) integrin CD11b/CD18 (Mac-1) and adhesion to plastic in a naloxone-reversible manner.
Negative_regulation (decreased) of Gene_expression (expression) of CD11b/CD18 in neutrophil associated with narcan and adhesions
3) Confidence 0.39 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11239930 Disease Relevance 0.18 Pain Relevance 0.78
U-50,488H also decreased neutrophil expression of the beta(2) integrin CD11b/CD18 (Mac-1) and adhesion to plastic in a naloxone-reversible manner.
Negative_regulation (decreased) of Gene_expression (expression) of CD11b/CD18 in neutrophil associated with narcan and adhesions
4) Confidence 0.39 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11239930 Disease Relevance 0.18 Pain Relevance 0.78
However, the 4 mg/kg of A. camphorata decreased the levels of CD11b and both doses of treatment increased CD3 and CD19.
Negative_regulation (decreased) of Gene_expression (levels) of CD11b
5) Confidence 0.39 Published 2010 Journal Nutr Cancer Section Abstract Doc Link 20574920 Disease Relevance 0.65 Pain Relevance 0.07
Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression.
Negative_regulation (inhibiting) of Gene_expression (expression) of Mac-1 in neutrophil associated with inflammation
6) Confidence 0.36 Published 1996 Journal Eur. J. Immunol. Section Title Doc Link 8566054 Disease Relevance 0.89 Pain Relevance 0.39
Within the F4/80 population, I/R triggered a nonsignificant decrease in CD11b expression in WT animals; however, in MC3R-null animals, a significant decrease was observed (Table 3).
Negative_regulation (decrease) of Gene_expression (expression) of CD11b in F4/80
7) Confidence 0.34 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.22 Pain Relevance 0
Moreover, 11a treatment attenuated expression of macrophage adhesion molecule-1 (Mac-1) on extravasated polymorphonuclear leukocytes (PMNs) which indicates that the activation was reduced.
Negative_regulation (attenuated) of Gene_expression (expression) of Mac-1 in polymorphonuclear leukocytes associated with adhesions
8) Confidence 0.34 Published 2009 Journal Bioorg. Med. Chem. Section Abstract Doc Link 19097798 Disease Relevance 0.88 Pain Relevance 0.40
CO had no impact on L-selectin expression, but tended to reduce CD11b expression on lung-marginated neutrophils.
Negative_regulation (reduce) of Gene_expression (expression) of CD11b in lung
9) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.08 Pain Relevance 0.04
Suppression of CR3 expression using Invivofectamine reagent.
Negative_regulation (Suppression) of Gene_expression (expression) of CR3
10) Confidence 0.30 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.12 Pain Relevance 0.03
The role of CR3-mediated clearance of E. coli from the blood was further substantiated in mice by suppressing CR3 expression using siRNA and Invivofectamine.
Negative_regulation (suppressing) of Gene_expression (expression) of CR3 in blood
11) Confidence 0.30 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.62 Pain Relevance 0.16
To suppress CR3 expression, newborn mice at day 1 were injected with CR3 siRNA or control siRNA in Invivofectamine reagent (premixed in 1:1 ratio, 10 nmol in 10 µl; Invitrogen).
Negative_regulation (suppress) of Gene_expression (expression) of CR3
12) Confidence 0.30 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.12 Pain Relevance 0.03
IL-10 treatment fails to protect mice that lack CR3 expression against E. coli–induced meningitis
Negative_regulation (lack) of Gene_expression (expression) of CR3 associated with meningitis
13) Confidence 0.30 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.43 Pain Relevance 0
These results collectively demonstrate that CR3 expression was significantly suppressed during the progression of the disease by E. coli K1 and the protective effects of rh-IL-10 are caused by restoration of CR3 expression in neutrophils and macrophages.


Negative_regulation (suppressed) of Gene_expression (expression) of CR3 in macrophages associated with disease
14) Confidence 0.30 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.43 Pain Relevance 0.08
Confocal analysis of immunostaining for CD11b in combination with Il-1?
Negative_regulation (immunostaining) of Gene_expression (analysis) of CD11b
15) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1274341 Disease Relevance 0.47 Pain Relevance 0.16
Consistently with the stimulation of microglial cell priming by HS oligosaccharides in the brain, deletion of the innate immune response mediators TLR4 or MyD88 in MPSIIIB mice showed substantial reduction of CD11b staining and of the expression level of IL1?
Negative_regulation (level) of Gene_expression (staining) of CD11b in microglial cell
16) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.39 Pain Relevance 0.04
Consistently with the stimulation of microglial cell priming by HS oligosaccharides in the brain, deletion of the innate immune response mediators TLR4 or MyD88 in MPSIIIB mice showed substantial reduction of CD11b staining and of the expression level of IL1?
Negative_regulation (reduction) of in brain Gene_expression (staining) of CD11b in microglial cell
17) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.38 Pain Relevance 0.04
To confirm that CR3 expression is critical in vivo for rh-IL-10 mediated protection against E. coli infection and brain damage, CR3 expression in mice was suppressed using Invivofectamine reagent.
Negative_regulation (suppressed) of Gene_expression (expression) of CR3 in brain associated with infection
18) Confidence 0.26 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.42 Pain Relevance 0
In addition to the massive infiltration of GFP+ macrophages/granulocytes 24 hours after pMCAO, we found that a small proportion of microglia in the infarcted cortex could be classified as GFP+ CD11b+CD45dim microglial cells.
Negative_regulation (classified) of Gene_expression (microglial cells) of CD11b in microglial cells
19) Confidence 0.25 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.27 Pain Relevance 0.07
Chronically activated microglia are characterized by their macrophagic morphology, CD11b expression, and release of neurotoxic cytokines IL-1?
Negative_regulation (morphology) of Gene_expression (expression) of CD11b in microglia associated with cytokine
20) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.80 Pain Relevance 0.09

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