INT61253

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 11.68
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sele) cell adhesion (Sele)
Anatomy Link Frequency
endothelial cells 2
joints 1
endothelium 1
neutrophil 1
Sele (Mus musculus)
Sele - S128R (1)
Pain Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
Inflammation 194 99.80 Very High Very High Very High
Arthritis 448 99.76 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 27 98.88 Very High Very High Very High
Inflammatory response 39 97.80 Very High Very High Very High
metalloproteinase 19 97.52 Very High Very High Very High
cytokine 191 97.44 Very High Very High Very High
chemokine 60 96.88 Very High Very High Very High
palliative 3 96.60 Very High Very High Very High
tolerance 6 93.04 High High
Disease Link Frequency Relevance Heat
Adhesions 153 100.00 Very High Very High Very High
INFLAMMATION 222 99.80 Very High Very High Very High
Arthritis 508 99.76 Very High Very High Very High
Hypothermia 55 99.68 Very High Very High Very High
Immunization 32 99.28 Very High Very High Very High
Cancer 47 99.22 Very High Very High Very High
Prostate Cancer 6 97.68 Very High Very High Very High
Coronary Artery Disease 68 97.32 Very High Very High Very High
Pain 8 96.84 Very High Very High Very High
Metastasis 3 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased serum E-selectin concentration after 89Sr-chloride therapy for metastatic prostate cancer bone pain.
Negative_regulation (Decreased) of E-selectin associated with pain and prostate cancer
1) Confidence 0.57 Published 2000 Journal J. Nucl. Med. Section Title Doc Link 10855628 Disease Relevance 0.38 Pain Relevance 0.39
This may be explained by a limit on how quickly a mouse can actually develop CIA, even with loss of both E-selectin and P-selectin.
Negative_regulation (loss) of E-selectin associated with arthritis
2) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.02 Pain Relevance 0.53
This would result in the observed elevated monokine production in mice lacking E-selectin and P-selectin.
Negative_regulation (lacking) of E-selectin
3) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.80 Pain Relevance 0.43
Therefore, we investigated whether the loss of E-selectin or P-selectin affected the expression levels of five different cytokines and chemokines that are implicated in the development of CIA.
Spec (whether) Negative_regulation (loss) of E-selectin associated with chemokine, arthritis and cytokine
4) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.01 Pain Relevance 0.58
RESULTS: A 2.8-fold decrease in serum E-selectin concentration occurred within 2 mo of radionuclide therapy (P < 0.0001).
Negative_regulation (decrease) of E-selectin
5) Confidence 0.42 Published 2000 Journal J. Nucl. Med. Section Body Doc Link 10855628 Disease Relevance 0.08 Pain Relevance 0
CONCLUSION: A significant decrease in serum E-selectin concentration was observed after systemic radionuclide therapy.
Negative_regulation (decrease) of E-selectin
6) Confidence 0.42 Published 2000 Journal J. Nucl. Med. Section Body Doc Link 10855628 Disease Relevance 0.06 Pain Relevance 0
Therefore, mice lacking both E-selectin and P-selectin are seemingly primed to mount a robust inflammatory response in their joints.
Negative_regulation (lacking) of E-selectin in joints associated with inflammatory response
7) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.90 Pain Relevance 0.47
To our knowledge, this study is the first to evaluate the prevalence of E-selectin polymorphism (S128R) and its potential relevance for angiographic CAD and its associated risk factors in the Arab population.
Negative_regulation (prevalence) of E-selectin (S128R) associated with coronary artery disease
8) Confidence 0.39 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1501005 Disease Relevance 1.52 Pain Relevance 0
Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression.
Negative_regulation (inhibiting) of E-selectin in neutrophil associated with inflammation
9) Confidence 0.32 Published 1996 Journal Eur. J. Immunol. Section Title Doc Link 8566054 Disease Relevance 0.88 Pain Relevance 0.39
Interaction of monocytes with endothelial cells is mediated by adhesion molecules located on the surface of these cells, which include VCAM-1, ICAM-1, and E-selectin.
Negative_regulation (include) of E-selectin in endothelial cells associated with adhesions
10) Confidence 0.13 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.09 Pain Relevance 0.18
In fact, Tull et al. showed that EPA had no ability to decrease adhesion molecules such as E-selectin and ICAM-1, representatives of endothelial surface adhesion molecules, in cultured endothelial cells stimulated with TNF-?
Negative_regulation (decrease) of E-selectin in endothelial cells associated with adhesions
11) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.91 Pain Relevance 0.04
In vitro studies show that hypothermia can reversibly inhibit E-selectin, without affecting L-selectin [173,174].
Negative_regulation (inhibit) of E-selectin associated with hypothermia
12) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 1.15 Pain Relevance 0.11
Soluble E-selectin was depressed after tPA thrombolysis and PTCA in comparison with controls, while the SK group showed an increase throughout the observation period.
Negative_regulation (depressed) of E-selectin associated with percutaneous transluminal coronary angioplasty
13) Confidence 0.07 Published 2001 Journal Crit Care Section Abstract Doc Link PMC31578 Disease Relevance 0.53 Pain Relevance 0.32
Andrographolide inhibits the adhesion of cancer cells to the activated endothelium by blocking E-selectin expression [57].
Negative_regulation (blocking) of E-selectin in endothelium associated with cancer and adhesions
14) Confidence 0.04 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 1.33 Pain Relevance 0.13

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