INT61255

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Context Info
Confidence 0.23
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.79
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
IEC-6 2
alveolar macrophages 2
lung 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 16 99.78 Very High Very High Very High
Inflammation 12 96.20 Very High Very High Very High
cytokine 6 95.68 Very High Very High Very High
Inflammatory response 1 93.08 High High
cINOD 3 91.68 High High
agonist 1 90.72 High High
antagonist 1 89.60 High High
chemokine 4 84.28 Quite High
Cannabinoid receptor 1 81.12 Quite High
analgesia 1 78.20 Quite High
Disease Link Frequency Relevance Heat
Bacterial Meningitis 7 100.00 Very High Very High Very High
Infection 11 99.86 Very High Very High Very High
Necrosis 2 98.46 Very High Very High Very High
Cancer 2 98.28 Very High Very High Very High
INFLAMMATION 13 96.20 Very High Very High Very High
Adhesions 3 90.04 High High
Injury 1 78.88 Quite High
Neurogenic Inflammation 1 68.88 Quite High
Inflammatory Bowel Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently we showed tepoxalin, previously known as a dual cyclooxygenase/lipoxygenase (CO/LO) inhibitor, to be a potent inhibitor of NF kappa B-induced transcription in vitro.
Negative_regulation (inhibitor) of Transcription (transcription) of NF kappa B
1) Confidence 0.23 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8566054 Disease Relevance 0.90 Pain Relevance 0.43
Taken together, these results suggest that chronic morphine treatment in an S. pneumoniae infection model suppresses NF-kappaB gene transcription in lung resident cells, which, in turn, modulates the transcriptional regulation of MIP-2 and inflammatory cytokines.
Negative_regulation (suppresses) of Transcription (transcription) of NF-kappaB gene in lung associated with inflammation, infection, cytokine and morphine
2) Confidence 0.19 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15611267 Disease Relevance 0.59 Pain Relevance 0.88
Arvanil also prevents tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activation by direct inhibition of IkappaBalpha degradation, NF-kappaB binding to DNA, and NF-kappaB-dependent transcription.
Negative_regulation (inhibition) of Transcription (transcription) of NF-kappaB-dependent associated with necrosis and cancer
3) Confidence 0.12 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16394182 Disease Relevance 0.42 Pain Relevance 0.32
Dexamethasone inhibited interleukin-1beta induced, NF-kappaB driven gene transcription only in IEC-6 and not in Caco-2 cells.
Negative_regulation (inhibited) of Transcription (transcription) of NF-kappaB in IEC-6
4) Confidence 0.04 Published 2001 Journal Int J Colorectal Dis Section Body Doc Link 11760899 Disease Relevance 0 Pain Relevance 0
Gene array analysis revealed that IkappaB transcription was induced by TNF-alpha and inhibited by lidocaine.
Negative_regulation (inhibited) of Transcription (transcription) of IkappaB
5) Confidence 0.04 Published 2010 Journal Immunobiology Section Body Doc Link 19559500 Disease Relevance 0.07 Pain Relevance 0
Furthermore, morphine treatment inhibited Streptococcus pneumoniae-induced NF-kappaB-dependent gene transcription in alveolar macrophages following 2 h of in vitro infection.
Negative_regulation (inhibited) of Transcription (transcription) of NF-kappaB-dependent in alveolar macrophages associated with bacterial meningitis, infection and morphine
6) Confidence 0.03 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18292587 Disease Relevance 0.82 Pain Relevance 0.57

General Comments

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