INT61257

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Context Info
Confidence 0.77
First Reported 1996
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 79
Total Number 80
Disease Relevance 70.97
Pain Relevance 17.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sele) cell adhesion (Sele)
Anatomy Link Frequency
endothelial cells 11
joint 7
leukocyte 5
brain 4
platelets 4
Sele (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1099 100.00 Very High Very High Very High
Inflammatory mediators 71 100.00 Very High Very High Very High
cytokine 810 99.98 Very High Very High Very High
Arthritis 1573 99.66 Very High Very High Very High
licofelone 16 99.66 Very High Very High Very High
cINOD 44 99.34 Very High Very High Very High
antagonist 108 99.28 Very High Very High Very High
chemokine 298 98.40 Very High Very High Very High
anesthesia 24 98.40 Very High Very High Very High
ischemia 155 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1227 100.00 Very High Very High Very High
Adhesions 699 100.00 Very High Very High Very High
Cancer 175 100.00 Very High Very High Very High
Necrosis 90 100.00 Very High Very High Very High
Viral Meningitis 70 99.96 Very High Very High Very High
Arthritis 1783 99.82 Very High Very High Very High
Multiple Sclerosis 61 99.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 373 99.58 Very High Very High Very High
Atherosclerotic Plaque 22 99.48 Very High Very High Very High
Disease 263 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: These results stress the need to determine E-selectin protein expression and not only mRNA expression, when choosing an animal model for testing E-selectin directed drug targeting preparations.
Spec (determine) Gene_expression (expression) of E-selectin protein
1) Confidence 0.77 Published 2003 Journal Inflamm. Res. Section Body Doc Link 14991080 Disease Relevance 0.07 Pain Relevance 0
Comparison of E-selectin expression at mRNA and protein levels in murine models of inflammation.
Gene_expression (expression) of E-selectin associated with inflammation
2) Confidence 0.77 Published 2003 Journal Inflamm. Res. Section Title Doc Link 14991080 Disease Relevance 0.43 Pain Relevance 0.46
RESULTS: In all animal models E-selectin mRNA expression was detected, although to a different extent.
Gene_expression (expression) of E-selectin mRNA
3) Confidence 0.77 Published 2003 Journal Inflamm. Res. Section Body Doc Link 14991080 Disease Relevance 0.08 Pain Relevance 0
Therapeutic effects of developed drug targeting constructs will have to be tested in animal models of inflammation, in which E-selectin is expressed during the course of the disease.
Gene_expression (expressed) of E-selectin associated with inflammation and disease
4) Confidence 0.77 Published 2003 Journal Inflamm. Res. Section Abstract Doc Link 14991080 Disease Relevance 0.45 Pain Relevance 0.27
In this study several murine models of inflammation were investigated regarding expression of E-selectin.
Gene_expression (expression) of E-selectin associated with inflammation
5) Confidence 0.77 Published 2003 Journal Inflamm. Res. Section Abstract Doc Link 14991080 Disease Relevance 0.53 Pain Relevance 0.26
METHODS: E-selectin expression was determined both at the mRNA level using RT-PCR and at the protein level by immunohistochemistry using two monoclonal antibodies (10E9.6 and MES-1).
Gene_expression (expression) of E-selectin
6) Confidence 0.77 Published 2003 Journal Inflamm. Res. Section Body Doc Link 14991080 Disease Relevance 0.10 Pain Relevance 0
In contrast, only the delayed type hypersensitivity model and, to a minor extent, the collagen induced arthritis model showed E-selectin protein expression.
Gene_expression (expression) of E-selectin protein
7) Confidence 0.77 Published 2003 Journal Inflamm. Res. Section Body Doc Link 14991080 Disease Relevance 0.07 Pain Relevance 0
These findings indicate that in early-onset arthritic joints, expression of E-selectin and P-selectin can significantly influence the production of IL-1?
Gene_expression (expression) of E-selectin in joints associated with arthritis
8) Confidence 0.75 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.83 Pain Relevance 0.30
In addition, several anti-inflammatory drugs have been shown to decrease the expression of E-selectin and P-selectin, as well as that of other adhesion molecules, in joint tissue from patients undergoing remission [7].
Gene_expression (expression) of E-selectin in joint associated with inflammation, cinod and adhesions
9) Confidence 0.75 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.37 Pain Relevance 0.55
Increased expression of E-selectin and P-selectin has been observed in inflamed joints from RA patients, with several studies showing significant elevations in soluble selectins in the serum of patients with active disease [7-10].
Gene_expression (expression) of E-selectin in joints associated with rheumatoid arthritis and disease
10) Confidence 0.75 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.19 Pain Relevance 0.46
L-selectin is expressed on the majority of leukocytes and is shed from the cell surface following activation, whereas P-selectin and E-selectin are expressed on endothelial cells following activation by various inflammatory mediators.
Gene_expression (expressed) of E-selectin in leukocytes associated with inflammatory mediators
11) Confidence 0.75 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.50 Pain Relevance 0.11
In addition, in the arthritis model, E-selectin protein detection was dependent on the particular anti-E-selectin antibody used.
Gene_expression (detection) of E-selectin protein
12) Confidence 0.67 Published 2003 Journal Inflamm. Res. Section Body Doc Link 14991080 Disease Relevance 0.06 Pain Relevance 0
However, the severity scores were not significantly different between E-selectin and E/P-selectin mutant mice (P = 0.23 for E-selectin versus E/P-selectin).


Neg (not) Gene_expression (different) of E-selectin
13) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.52 Pain Relevance 0.39
Our previous and current studies in the CIA model show that leukocyte rolling via E-selectin and P-selectin is not required for the initiation of arthritis, and that loss of one or both of these adhesion molecules significantly accelerates the development and severity of joint inflammation.
Gene_expression (leukocyte) of E-selectin in joint associated with inflammation, adhesions and arthritis
14) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.27 Pain Relevance 0.54
Therefore, mice lacking both E-selectin and P-selectin are seemingly primed to mount a robust inflammatory response in their joints.
Neg (lacking) Gene_expression (lacking) of E-selectin in joints associated with inflammatory response
15) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.90 Pain Relevance 0.47
Additionally, both the E-selectin and E/P-selectin mutants had significantly higher average daily severity scores than did wild-type mice (Fig. 2).
Gene_expression (mutants) of E-selectin
16) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.56 Pain Relevance 0.34
C-UA, but not T-UA, induced local effects of liberated mast cell TNF-alpha, as detected by E-selectin expression on the microvascular dermal endothelium.
Gene_expression (expression) of E-selectin in endothelium
17) Confidence 0.64 Published 1999 Journal Skin Pharmacol. Appl. Skin Physiol. Section Abstract Doc Link 10325580 Disease Relevance 0.42 Pain Relevance 0.15
Therefore, we investigated whether the loss of E-selectin or P-selectin affected the expression levels of five different cytokines and chemokines that are implicated in the development of CIA.
Gene_expression (expression) of E-selectin associated with chemokine, arthritis and cytokine
18) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.07 Pain Relevance 0.61
Overall, these data illustrate the novel finding that E-selectin and P-selectin expression can significantly influence cytokine and chemokine production in joint tissue, and suggest that these adhesion molecules play important regulatory roles in the development of arthritis in E/P-selectin mutant mice.



Gene_expression (expression) of E-selectin in joint associated with chemokine, adhesions, arthritis and cytokine
19) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257424 Disease Relevance 1.05 Pain Relevance 0.53
Since it has been documented that the expression of E-selectin and Mac-1 is regulated either directly or indirectly by the transcription factor NF kappa B, our studies provide in vivo evidence that tepoxalin is a potent inhibitor of NF kappa B-mediated events in animal models and this novel molecular mechanism clearly defines it as a new class of anti-inflammatory compounds.
Gene_expression (expression) of E-selectin associated with inflammation
20) Confidence 0.58 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8566054 Disease Relevance 0.64 Pain Relevance 0.32

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