INT61258

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 10.89
Pain Relevance 6.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
fibroblast 2
lungs 2
macrophages 1
IEC-6 1
Hook 1
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 11 100.00 Very High Very High Very High
cINOD 44 99.44 Very High Very High Very High
Inflammatory response 15 99.20 Very High Very High Very High
Migraine 3 99.16 Very High Very High Very High
Inflammation 307 99.14 Very High Very High Very High
Morphine 16 98.92 Very High Very High Very High
cytokine 62 95.68 Very High Very High Very High
substance P 22 95.04 Very High Very High Very High
aspirin 19 94.56 High High
Antinociceptive 2 94.16 High High
Disease Link Frequency Relevance Heat
Cancer 67 99.84 Very High Very High Very High
Bacterial Meningitis 8 99.82 Very High Very High Very High
Infection 23 99.64 Very High Very High Very High
Necrosis 16 99.56 Very High Very High Very High
Headache 3 99.16 Very High Very High Very High
INFLAMMATION 343 99.14 Very High Very High Very High
Death 17 97.52 Very High Very High Very High
Asthma 32 96.40 Very High Very High Very High
Fever 10 94.32 High High
Pain 5 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Transcription (transcription) of NF-kappaB associated with necrosis and cancer
1) Confidence 0.67 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.52 Pain Relevance 0.24
Here we demonstrate that transcription from a promoter containing NF-kappaB binding sequences as well as the DNA binding activity of NF-kappaB were increased in PDGF-B-chain-transformed mouse fibroblast cells.
Transcription (transcription) of NF-kappaB in fibroblast
2) Confidence 0.63 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 11855867 Disease Relevance 0.25 Pain Relevance 0.15
Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages.
Transcription (transcription) of nuclear factor kappa B in macrophages associated with cox2
3) Confidence 0.54 Published 2010 Journal Cell. Signal. Section Title Doc Link 20546888 Disease Relevance 0.44 Pain Relevance 0.28
These findings substantiate the hypothesis of transitory delayed inflammation, as suggested by the animal model, and suggest the possibility of using therapeutic approaches to target NF-kappaB transcription in the treatment of migraine.
Transcription (transcription) of NF-kappaB associated with inflammation and migraine
4) Confidence 0.53 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16919057 Disease Relevance 0.43 Pain Relevance 0.30
B-p50 mRNA expression was significantly increased with exposure in Ppar?
Transcription (expression) of p50
5) Confidence 0.49 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.16 Pain Relevance 0
Therefore, the transcription factor NF-kappaB plays a vital role in PDGF-B chain transformation of mouse fibroblast cells, and the NF-kappaB activity is sensitive to treatment with ASA.
Transcription (transcription) of NF-kappaB in fibroblast associated with aspirin
6) Confidence 0.48 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 11855867 Disease Relevance 0.20 Pain Relevance 0.22
Others have presented evidence that BCG activates nuclear translocation of the transcription factor NF-kappaB, since pretreatment of with sulfasalazine, an inhibitor of NF-kappaB activity, blocked the ability of BCG to induce IL-8 secretion [48,49].
Transcription (transcription) of NF-kappaB
7) Confidence 0.39 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.54 Pain Relevance 0.11
To determine whether activation of NK1R increases the transcriptional activities of NF-kappaB and Nkx-2.5, an EMSA was performed.
Transcription (transcriptional) of NF-kappaB
8) Confidence 0.32 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
Recently we showed tepoxalin, previously known as a dual cyclooxygenase/lipoxygenase (CO/LO) inhibitor, to be a potent inhibitor of NF kappa B-induced transcription in vitro.
Transcription (transcription) of NF kappa B
9) Confidence 0.28 Published 1996 Journal Eur. J. Immunol. Section Abstract Doc Link 8566054 Disease Relevance 0.90 Pain Relevance 0.43
Indeed, there are still increasing evidences that the blockade of MAPK inhibited NF-kappa B-dependent gene transcription without affecting IkappaBalpha phosphorylation and NF-kappa B-DNA binding ability [9,24-27].
Transcription (transcription) of NF-kappa B-dependent
10) Confidence 0.23 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.22 Pain Relevance 0.04
Taken together, these results suggest that chronic morphine treatment in an S. pneumoniae infection model suppresses NF-kappaB gene transcription in lung resident cells, which, in turn, modulates the transcriptional regulation of MIP-2 and inflammatory cytokines.
Transcription (transcription) of NF-kappaB gene in lung associated with inflammation, infection, cytokine and morphine
11) Confidence 0.23 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15611267 Disease Relevance 0.59 Pain Relevance 0.88
Furthermore, increased levels of ROS have been implicated in initiating inflammatory responses in the lungs through the activation of transcription factors such as nuclear factor-kappaB (NF-?
Transcription (transcription) of nuclear factor-kappaB in lungs associated with inflammatory response
12) Confidence 0.22 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.56 Pain Relevance 0.13
[20] It is also known that several diterpenoids isolated from the Chinese herb Isodon rubescens are potent inhibitors of NF-kappa B transcriptional activity which subsequently target iNOS and cycloxygenase-2 (COX-2), with the latter being less sensitive to diterpenoids.[21] Other diterpenoids isolated from Chinese herbal remedy (Tripterygium wilfordii Hook.f.) inhibit the interleukin-1?
Transcription (transcriptional) of NF-kappa B in Hook
13) Confidence 0.19 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959212 Disease Relevance 0.61 Pain Relevance 0.24
Thus, the ability of the transcription factors AP-1 and NF-kappaB to induce gene transcription is attenuated by GR.
Transcription (transcription) of NF-kappaB
14) Confidence 0.17 Published 2001 Journal Immunol. Cell Biol. Section Abstract Doc Link 11488985 Disease Relevance 1.03 Pain Relevance 0.37
NSAIDs are able to inactivate the transcription NF-kB and activator protein-1 (AP-1), critically involved in the induction of multiple inflammatory gene products involved in the inflammatory response (i.e. iNOS, TNF-?).
Transcription (transcription) of NF-kB associated with inflammatory response, inflammation and cinod
15) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.60 Pain Relevance 0.47
The immediate downstream proteins and transcription factors of p38 MAP kinase are still in the process of being defined, and have not been studied in prostate. p38 MAP kinase is well known to activate the transcription factor NF-Kappa B [83]. p38 MAP kinase also appears to have some role in activating caspases [84]. p38 is also able to increase the expression of certain proteins including chromium induced HIF-1?
Transcription (transcription) of NF-Kappa B
16) Confidence 0.14 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.07 Pain Relevance 0.04
Arvanil also prevents tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activation by direct inhibition of IkappaBalpha degradation, NF-kappaB binding to DNA, and NF-kappaB-dependent transcription.
Transcription (transcription) of NF-kappaB associated with necrosis and cancer
17) Confidence 0.14 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16394182 Disease Relevance 0.42 Pain Relevance 0.32
Arvanil also prevents tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activation by direct inhibition of IkappaBalpha degradation, NF-kappaB binding to DNA, and NF-kappaB-dependent transcription.
Transcription (transcription) of NF-kappaB-dependent associated with necrosis and cancer
18) Confidence 0.14 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16394182 Disease Relevance 0.41 Pain Relevance 0.31
Dexamethasone inhibited interleukin-1beta induced, NF-kappaB driven gene transcription only in IEC-6 and not in Caco-2 cells.
Transcription (transcription) of NF-kappaB in IEC-6
19) Confidence 0.07 Published 2001 Journal Int J Colorectal Dis Section Body Doc Link 11760899 Disease Relevance 0 Pain Relevance 0
Gene array analysis revealed that IkappaB transcription was induced by TNF-alpha and inhibited by lidocaine.
Transcription (transcription) of IkappaB
20) Confidence 0.04 Published 2010 Journal Immunobiology Section Body Doc Link 19559500 Disease Relevance 0.07 Pain Relevance 0

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